PDB: 1a5h Compound: tissue plasminogen activator Classification: HYDROLASE Entry date in PDB: 1999-04-20 Resolution [Å]: 2.90 R-Factor: 0.178

CHAIN: A SWISS-PROT/TREMBL: P00750    KEYWORD: 3D-structure    Alternative splicing    EGF-like domain    Glycoprotein    Hydrolase    Kringle    Pharmaceutical    Plasma    Plasminogen activation    Polymorphism    Repeat    Serine protease    Signal    EC: 3.4.21.68 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Two-chain tissue plasminogen activator (TC)-T-PA    Human (Homo sapiens) GO:  extracellular region    chymotrypsin activity    plasminogen activator activity    trypsin activity    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P00750    KEYWORD: 3D-structure    Alternative splicing    EGF-like domain    Glycoprotein    Hydrolase    Kringle    Pharmaceutical    Plasma    Plasminogen activation    Polymorphism    Repeat    Serine protease    Signal    EC: 3.4.21.68 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Two-chain tissue plasminogen activator (TC)-T-PA    Human (Homo sapiens) GO:  extracellular region    chymotrypsin activity    plasminogen activator activity    trypsin activity    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P00750    KEYWORD: 3D-structure    Alternative splicing    EGF-like domain    Glycoprotein    Hydrolase    Kringle    Pharmaceutical    Plasma    Plasminogen activation    Polymorphism    Repeat    Serine protease    Signal    EC: 3.4.21.68 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Two-chain tissue plasminogen activator (TC)-T-PA    Human (Homo sapiens) GO:  extracellular region    chymotrypsin activity    plasminogen activator activity    trypsin activity    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: P00750    KEYWORD: 3D-structure    Alternative splicing    EGF-like domain    Glycoprotein    Hydrolase    Kringle    Pharmaceutical    Plasma    Plasminogen activation    Polymorphism    Repeat    Serine protease    Signal    EC: 3.4.21.68 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Two-chain tissue plasminogen activator (TC)-T-PA    Human (Homo sapiens) GO:  extracellular region    chymotrypsin activity    plasminogen activator activity    trypsin activity    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB-EC clusters

1a5h_A_135 - HA => SUBCLASS : 15.3.1

Loops not clustered in ArchDB

1a5h_A_20 - AR
1a5h_A_180 - AR
1a5h_A_51 - AR
1a5h_A_104 - AR
1a5h_A_226 - EH
1a5h_A_198 - HA
1a5h_A_156 - HA
1a5h_A_81 - HA
1a5h_A_64 - HA
1a5h_A_39 - HA
1a5h_A_30 - HA
1a5h_A_206 - HA

1a5h A - percentage of sequence identity: 100
1a5h B - percentage of sequence identity: 100
1a5i A - percentage of sequence identity: 79
1bda A - percentage of sequence identity: 100
1bda B - percentage of sequence identity: 100
1rtf B - percentage of sequence identity: 100