PDB: 1a81 Compound: syk kinase Classification: COMPLEX (TRANSFERASE/PEPTIDE) Entry date in PDB: 1998-10-21 Resolution [Å]: 3.00 R-Factor: 0.226

CHAIN: A SWISS-PROT/TREMBL: P43405    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Phosphorylation    Repeat    SH2 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: B SWISS-PROT/TREMBL: P07766    KEYWORD: Immunoglobulin domain    Phosphorylation    Receptor    Signal    T-cell    Transmembrane    GO:  membrane    transmembrane receptor activity    cell surface receptor linked signal transduction    CHAIN: C SWISS-PROT/TREMBL: P43405    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Phosphorylation    Repeat    SH2 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: D SWISS-PROT/TREMBL: P07766    KEYWORD: Immunoglobulin domain    Phosphorylation    Receptor    Signal    T-cell    Transmembrane    GO:  membrane    transmembrane receptor activity    cell surface receptor linked signal transduction    CHAIN: E SWISS-PROT/TREMBL: P43405    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Phosphorylation    Repeat    SH2 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: F SWISS-PROT/TREMBL: P07766    KEYWORD: Immunoglobulin domain    Phosphorylation    Receptor    Signal    T-cell    Transmembrane    GO:  membrane    transmembrane receptor activity    cell surface receptor linked signal transduction    CHAIN: G SWISS-PROT/TREMBL: P43405    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Phosphorylation    Repeat    SH2 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: H SWISS-PROT/TREMBL: P07766    KEYWORD: Immunoglobulin domain    Phosphorylation    Receptor    Signal    T-cell    Transmembrane    GO:  membrane    transmembrane receptor activity    cell surface receptor linked signal transduction    CHAIN: I SWISS-PROT/TREMBL: P43405    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Phosphorylation    Repeat    SH2 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: J SWISS-PROT/TREMBL: P07766    KEYWORD: Immunoglobulin domain    Phosphorylation    Receptor    Signal    T-cell    Transmembrane    GO:  membrane    transmembrane receptor activity    cell surface receptor linked signal transduction    CHAIN: K SWISS-PROT/TREMBL: P43405    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Phosphorylation    Repeat    SH2 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Syk tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation    CHAIN: L SWISS-PROT/TREMBL: P07766    KEYWORD: Immunoglobulin domain    Phosphorylation    Receptor    Signal    T-cell    Transmembrane    GO:  membrane    transmembrane receptor activity    cell surface receptor linked signal transduction

Image Source: PDB

Loops in ArchDB-EC clusters

1a81_A_38 - HA => SUBCLASS : 6.1.1

Loops not clustered in ArchDB

1a81_A_74 - EH
1a81_E_226 - EH
1a81_E_169 - EH
1a81_E_73 - EH
1a81_E_16 - EH
1a81_A_226 - EH
1a81_A_169 - EH
1a81_A_105 - EH
1a81_A_192 - HA
1a81_A_203 - HA
1a81_A_212 - HA
1a81_E_38 - HA
1a81_E_51 - HA
1a81_E_61 - HA
1a81_E_192 - HA
1a81_E_202 - HA
1a81_A_60 - HA
1a81_A_51 - HA
1a81_E_212 - HA
1a81_E_175 - HE
1a81_A_22 - HE
1a81_A_85 - HE
1a81_A_140 - HE
1a81_A_175 - HE
1a81_E_22 - HE
1a81_E_154 - HE
1a81_A_121 - HH
1a81_E_85 - HH

1a81 A - percentage of sequence identity: 100
1a81 C - percentage of sequence identity: 100
1a81 E - percentage of sequence identity: 100
1a81 G - percentage of sequence identity: 100
1a81 I - percentage of sequence identity: 100
1a81 K - percentage of sequence identity: 100