PDB: 1bkc Compound: tumor necrosis factor-alpha-converting enzyme Classification: ZN-ENDOPEPTIDASE Entry date in PDB: 1999-06-22 Resolution [Å]: 2.00 R-Factor: 0.180

CHAIN: A SWISS-PROT/TREMBL: P78536    KEYWORD: 3D-structure    Alternative splicing    Glycoprotein    Hydrolase    Metalloprotease    Phosphorylation    SH3-binding    Signal    Transmembrane    Zinc    Zymogen    EC: 3.4.24.86 SCOP: d.92.1.10 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    Human (Homo sapiens) GO:  metalloendopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P78536    KEYWORD: 3D-structure    Alternative splicing    Glycoprotein    Hydrolase    Metalloprotease    Phosphorylation    SH3-binding    Signal    Transmembrane    Zinc    Zymogen    EC: 3.4.24.86 SCOP: d.92.1.10 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    Human (Homo sapiens) GO:  metalloendopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis    CHAIN: E SWISS-PROT/TREMBL: P78536    KEYWORD: 3D-structure    Alternative splicing    Glycoprotein    Hydrolase    Metalloprotease    Phosphorylation    SH3-binding    Signal    Transmembrane    Zinc    Zymogen    EC: 3.4.24.86 SCOP: d.92.1.10 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    Human (Homo sapiens) GO:  metalloendopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis    CHAIN: I SWISS-PROT/TREMBL: P78536    KEYWORD: 3D-structure    Alternative splicing    Glycoprotein    Hydrolase    Metalloprotease    Phosphorylation    SH3-binding    Signal    Transmembrane    Zinc    Zymogen    EC: 3.4.24.86 SCOP: d.92.1.10 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    TNF-alpha converting enzyme, TACE, catalytic domain    Human (Homo sapiens) GO:  metalloendopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB40 clusters

1bkc_A_326 - HE => SUBCLASS : 2.3.12
1bkc_A_326 - HE => SUBCLASS : 2.5.4
1bkc_A_388 - HA => SUBCLASS : 2.1.1
1bkc_A_392 - EH => SUBCLASS : 1.1.4
1bkc_A_382 - AR => SUBCLASS : 1.1.1

Loops in ArchDB95 clusters

1bkc_A_392 - EH => SUBCLASS : 2.2.1
1bkc_A_382 - AR => SUBCLASS : 1.2.3
1bkc_A_326 - HE => SUBCLASS : 2.3.21
1bkc_A_388 - HA => SUBCLASS : 2.1.1

Loops in ArchDB-EC clusters

1bkc_A_326 - HE => SUBCLASS : 2.2.5

Loops not clustered in ArchDB

1bkc_A_376 - AR
1bkc_A_334 - AR
1bkc_A_349 - AR
1bkc_A_334 - AR
1bkc_A_349 - AR
1bkc_A_376 - AR
1bkc_A_382 - AR
1bkc_A_276 - EH
1bkc_A_224 - EH
1bkc_A_369 - HA
1bkc_A_369 - HA
1bkc_A_388 - HA
1bkc_A_244 - HE
1bkc_A_396 - HH
1bkc_A_314 - HH
1bkc_A_233 - HH

1bkc A - percentage of sequence identity: 100
1bkc C - percentage of sequence identity: 100
1bkc E - percentage of sequence identity: 99
1bkc I - percentage of sequence identity: 99
1zxc A - percentage of sequence identity: 100
1zxc B - percentage of sequence identity: 100
2a8h A - percentage of sequence identity: 100
2a8h B - percentage of sequence identity: 100