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Information on 1btk
PDB: 1btk
Compound: bruton's tyrosine kinase
Classification: TRANSFERASE
Entry date in PDB: 1997-09-17
Resolution [Å]: 1.60
R-Factor: 0.231


CHAIN: A
SWISS-PROT/TREMBL: Q06187
   KEYWORD: 3D-structure    ATP-binding    Disease mutation    Metal-binding    Phosphorylation    Polymorphism    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    Zinc   
EC: 2.7.1.112
SCOP: b.55.1.1 All beta proteins    PH domain-like    PH domain-like    Pleckstrin-homology domain (PH domain)    Bruton's tyrosine kinase    Human (Homo sapiens)
GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation   


CHAIN: B
SWISS-PROT/TREMBL: Q06187
   KEYWORD: 3D-structure    ATP-binding    Disease mutation    Metal-binding    Phosphorylation    Polymorphism    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    Zinc   
EC: 2.7.1.112
SCOP: b.55.1.1 All beta proteins    PH domain-like    PH domain-like    Pleckstrin-homology domain (PH domain)    Bruton's tyrosine kinase    Human (Homo sapiens)
GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation   
1btk Image
Image Source: PDB

Stored Loops of 1btk

Loops in ArchDB40 clusters

1btk_A_147 - HA => SUBCLASS : 2.1.1
1btk_A_25 - HA => SUBCLASS : 2.2.3
1btk_A_36 - HA => SUBCLASS : 4.1.2
1btk_A_111 - EH => SUBCLASS : 2.1.1
1btk_A_141 - AR => SUBCLASS : 2.1.6
1btk_A_48 - AR => SUBCLASS : 3.4.1
1btk_A_48 - AR => SUBCLASS : 4.2.1

Loops in ArchDB95 clusters

1btk_A_111 - EH => SUBCLASS : 2.1.1
1btk_A_48 - AR => SUBCLASS : 3.2.11
1btk_A_48 - AR => SUBCLASS : 4.4.1
1btk_A_147 - HA => SUBCLASS : 2.1.1
1btk_A_25 - HA => SUBCLASS : 2.2.3
1btk_A_36 - HA => SUBCLASS : 4.1.2

Loops in ArchDB-EC clusters

1btk_A_36 - HA => SUBCLASS : 4.1.2

Loops not clustered in ArchDB

1btk_A_151 - AR
1btk_A_141 - AR
1btk_A_48 - AR
1btk_A_151 - AR
1btk_A_61 - EH
1btk_A_100 - HA
1btk_A_6 - HA
1btk_A_6 - HA
1btk_A_36 - HA
1btk_A_100 - HA
1btk_A_147 - HA
1btk_A_25 - HA
1btk_A_118 - HE
1btk_A_93 - HE

Homologous structures to 1btk classified in ArchDB

1b55 A - percentage of sequence identity: 99
1b55 B - percentage of sequence identity: 99
1btk A - percentage of sequence identity: 100
1btk B - percentage of sequence identity: 100
1bwn A - percentage of sequence identity: 98
1bwn B - percentage of sequence identity: 98