PDB: 1es7 Compound: bone morphogenetic protein-2 Classification: CYTOKINE Entry date in PDB: 2000-10-07 Resolution [Å]: 2.90 R-Factor: 0.191

CHAIN: A SWISS-PROT/TREMBL: P12643    KEYWORD: 3D-structure    Chondrogenesis    Cytokine    Glycoprotein    Growth factor    Osteogenesis    Signal    SCOP: g.17.1.2 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Transforming growth factor (TGF)-beta    Bone morphogenetic protein-2 (BMP-2)    Human (Homo sapiens) GO:  extracellular region    growth factor activity    growth    CHAIN: B SWISS-PROT/TREMBL: P36894    KEYWORD: 3D-structure    ATP-binding    Disease mutation    Glycoprotein    Receptor    Serine/threonine-protein kinase    Signal    Transferase    Transmembrane    EC: 2.7.1.37 SCOP: g.7.1.3 Small proteins    Snake toxin-like    Snake toxin-like    Extracellular domain of cell surface receptors    BMP receptor Ia ectodomain    Human (Homo sapiens) GO:  membrane    ATP binding    protein kinase activity    protein serine/threonine kinase activity    protein-tyrosine kinase activity    receptor signaling protein serine/threonine kinase activity    transforming growth factor beta receptor activity    transmembrane receptor protein serine/threonine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein serine/threonine kinase signaling pathway    CHAIN: C SWISS-PROT/TREMBL: P12643    KEYWORD: 3D-structure    Chondrogenesis    Cytokine    Glycoprotein    Growth factor    Osteogenesis    Signal    SCOP: g.17.1.2 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Transforming growth factor (TGF)-beta    Bone morphogenetic protein-2 (BMP-2)    Human (Homo sapiens) GO:  extracellular region    growth factor activity    growth    CHAIN: D SWISS-PROT/TREMBL: P36894    KEYWORD: 3D-structure    ATP-binding    Disease mutation    Glycoprotein    Receptor    Serine/threonine-protein kinase    Signal    Transferase    Transmembrane    EC: 2.7.1.37 SCOP: g.7.1.3 Small proteins    Snake toxin-like    Snake toxin-like    Extracellular domain of cell surface receptors    BMP receptor Ia ectodomain    Human (Homo sapiens) GO:  membrane    ATP binding    protein kinase activity    protein serine/threonine kinase activity    protein-tyrosine kinase activity    receptor signaling protein serine/threonine kinase activity    transforming growth factor beta receptor activity    transmembrane receptor protein serine/threonine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein serine/threonine kinase signaling pathway

Image Source: PDB

Loops in ArchDB-EC clusters

1es7_B_272 - EH => SUBCLASS : 3.29.1

Loops not clustered in ArchDB

1es7_B_252 - AR
1es7_B_236 - HA
1es7_B_258 - HA
1es7_B_283 - HE

1es7 B - percentage of sequence identity: 100
1es7 D - percentage of sequence identity: 100
1rew C - percentage of sequence identity: 100
1rew D - percentage of sequence identity: 100