PDB: 1fdv Compound: 17-beta-hydroxysteroid dehydrogenase Classification: DEHYDROGENASE Entry date in PDB: 1998-05-27 Resolution [Å]: 3.10 R-Factor: 0.219

CHAIN: A SWISS-PROT/TREMBL: P14061    KEYWORD: 3D-structure    Multigene family    NAD    Oxidoreductase    Polymorphism    Steroid biosynthesis    EC: 1.1.1.62 SCOP: c.2.1.2 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Tyrosine-dependent oxidoreductases    Human estrogenic 17beta-hydroxysteroid dehydrogenase    Human (Homo sapiens) GO:  cytoplasm    estradiol 17-beta-dehydrogenase activity    oxidoreductase activity    estrogen biosynthesis    metabolism    CHAIN: B SWISS-PROT/TREMBL: P14061    KEYWORD: 3D-structure    Multigene family    NAD    Oxidoreductase    Polymorphism    Steroid biosynthesis    EC: 1.1.1.62 SCOP: c.2.1.2 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Tyrosine-dependent oxidoreductases    Human estrogenic 17beta-hydroxysteroid dehydrogenase    Human (Homo sapiens) GO:  cytoplasm    estradiol 17-beta-dehydrogenase activity    oxidoreductase activity    estrogen biosynthesis    metabolism    CHAIN: C SWISS-PROT/TREMBL: P14061    KEYWORD: 3D-structure    Multigene family    NAD    Oxidoreductase    Polymorphism    Steroid biosynthesis    EC: 1.1.1.62 SCOP: c.2.1.2 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Tyrosine-dependent oxidoreductases    Human estrogenic 17beta-hydroxysteroid dehydrogenase    Human (Homo sapiens) GO:  cytoplasm    estradiol 17-beta-dehydrogenase activity    oxidoreductase activity    estrogen biosynthesis    metabolism    CHAIN: D SWISS-PROT/TREMBL: P14061    KEYWORD: 3D-structure    Multigene family    NAD    Oxidoreductase    Polymorphism    Steroid biosynthesis    EC: 1.1.1.62 SCOP: c.2.1.2 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Tyrosine-dependent oxidoreductases    Human estrogenic 17beta-hydroxysteroid dehydrogenase    Human (Homo sapiens) GO:  cytoplasm    estradiol 17-beta-dehydrogenase activity    oxidoreductase activity    estrogen biosynthesis    metabolism

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1jtv A - percentage of sequence identity: 99