PDB: 1fg9 Compound: interferon gamma Classification: IMMUNE SYSTEM Entry date in PDB: 2000-08-11 Resolution [Å]: 2.90 R-Factor: 0.237

CHAIN: A SWISS-PROT/TREMBL: P01579    KEYWORD: 3D-structure    Antiviral    Cytokine    Glycoprotein    Growth regulation    Pharmaceutical    Polymorphism    Signal    3D-structure    Antiviral    Cytokine    Glycoprotein    Growth regulation    Pharmaceutical    Polymorphism    Signal    SCOP: a.26.1.3 All alpha proteins    4-helical cytokines    4-helical cytokines    Interferons/interleukin-10 (IL-10)    Interferon-gamma    Human (Homo sapiens) GO:  extracellular region    interferon-gamma receptor binding    immune response    CHAIN: B SWISS-PROT/TREMBL: P01579    KEYWORD: 3D-structure    Antiviral    Cytokine    Glycoprotein    Growth regulation    Pharmaceutical    Polymorphism    Signal    3D-structure    Antiviral    Cytokine    Glycoprotein    Growth regulation    Pharmaceutical    Polymorphism    Signal    SCOP: a.26.1.3 All alpha proteins    4-helical cytokines    4-helical cytokines    Interferons/interleukin-10 (IL-10)    Interferon-gamma    Human (Homo sapiens) GO:  extracellular region    interferon-gamma receptor binding    immune response    CHAIN: C SWISS-PROT/TREMBL: P15260    KEYWORD: 3D-structure    Disease mutation    Glycoprotein    Immunoglobulin domain    Phosphorylation    Receptor    Signal    Transmembrane    SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) GO:  membrane    cytokine binding    hematopoietin/interferon-class (D200-domain) cytokine receptor activity    CHAIN: D SWISS-PROT/TREMBL: P15260    KEYWORD: 3D-structure    Disease mutation    Glycoprotein    Immunoglobulin domain    Phosphorylation    Receptor    Signal    Transmembrane    SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) GO:  membrane    cytokine binding    hematopoietin/interferon-class (D200-domain) cytokine receptor activity    CHAIN: E SWISS-PROT/TREMBL: P15260    KEYWORD: 3D-structure    Disease mutation    Glycoprotein    Immunoglobulin domain    Phosphorylation    Receptor    Signal    Transmembrane    SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) GO:  membrane    cytokine binding    hematopoietin/interferon-class (D200-domain) cytokine receptor activity

Image Source: PDB

1d9c A - percentage of sequence identity: 60
1fyh B - percentage of sequence identity: 100