PDB: 1gxd Compound: 72 kda type iv collagenase Classification: HYDROLASE Entry date in PDB: 2002-07-09 Resolution [Å]: 3.10 R-Factor: 0.278

CHAIN: A SWISS-PROT/TREMBL: P08253    KEYWORD: 3D-structure    Calcium-binding    Collagen degradation    Extracellular matrix    Glycoprotein    Hydrolase    Metal-binding    Metalloprotease    Repeat    Signal    Zinc    Zymogen    EC: 3.4.24.24 SCOP: a.20.1.2 All alpha proteins    PGBD-like    PGBD-like    MMP N-terminal domain    Gelatinase A (MMP-2)    Human (Homo sapiens) SCOP: b.66.1.1 All beta proteins    4-bladed beta-propeller    Hemopexin-like domain    Hemopexin-like domain    Gelatinase A (MMP-2), C-terminal domain    Human (Homo sapiens) SCOP: d.92.1.11 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    Matrix metalloproteases, catalytic domain    Gelatinase A    Human (Homo sapiens) SCOP: d.92.1.11 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    Matrix metalloproteases, catalytic domain    Gelatinase A    Human (Homo sapiens) SCOP: g.14.1.2 Small proteins    Kringle-like    Kringle-like    Fibronectin type II module    Gelatinase A (MMP-2) type II modules    Human (Homo sapiens) SCOP: g.14.1.2 Small proteins    Kringle-like    Kringle-like    Fibronectin type II module    Gelatinase A (MMP-2) type II modules    Human (Homo sapiens) SCOP: g.14.1.2 Small proteins    Kringle-like    Kringle-like    Fibronectin type II module    Gelatinase A (MMP-2) type II modules    Human (Homo sapiens) GO:  extracellular matrix (sensu Metazoa)    metalloendopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P08253    KEYWORD: 3D-structure    Calcium-binding    Collagen degradation    Extracellular matrix    Glycoprotein    Hydrolase    Metal-binding    Metalloprotease    Repeat    Signal    Zinc    Zymogen    EC: 3.4.24.24 SCOP: a.20.1.2 All alpha proteins    PGBD-like    PGBD-like    MMP N-terminal domain    Gelatinase A (MMP-2)    Human (Homo sapiens) SCOP: b.66.1.1 All beta proteins    4-bladed beta-propeller    Hemopexin-like domain    Hemopexin-like domain    Gelatinase A (MMP-2), C-terminal domain    Human (Homo sapiens) SCOP: d.92.1.11 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    Matrix metalloproteases, catalytic domain    Gelatinase A    Human (Homo sapiens) SCOP: d.92.1.11 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    Matrix metalloproteases, catalytic domain    Gelatinase A    Human (Homo sapiens) SCOP: g.14.1.2 Small proteins    Kringle-like    Kringle-like    Fibronectin type II module    Gelatinase A (MMP-2) type II modules    Human (Homo sapiens) SCOP: g.14.1.2 Small proteins    Kringle-like    Kringle-like    Fibronectin type II module    Gelatinase A (MMP-2) type II modules    Human (Homo sapiens) SCOP: g.14.1.2 Small proteins    Kringle-like    Kringle-like    Fibronectin type II module    Gelatinase A (MMP-2) type II modules    Human (Homo sapiens) GO:  extracellular matrix (sensu Metazoa)    metalloendopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P16035    KEYWORD: 3D-structure    Metalloprotease inhibitor    Signal    SCOP: b.40.3.1 All beta proteins    OB-fold    TIMP-like    Tissue inhibitor of metalloproteinases, TIMP    TIMP-2    Human (Homo sapiens) GO:  extracellular matrix (sensu Metazoa)    metalloendopeptidase inhibitor activity    CHAIN: D SWISS-PROT/TREMBL: P16035    KEYWORD: 3D-structure    Metalloprotease inhibitor    Signal    SCOP: b.40.3.1 All beta proteins    OB-fold    TIMP-like    Tissue inhibitor of metalloproteinases, TIMP    TIMP-2    Human (Homo sapiens) GO:  extracellular matrix (sensu Metazoa)    metalloendopeptidase inhibitor activity

Image Source: PDB

1br9 - - percentage of sequence identity: 100
1gen - - percentage of sequence identity: 100
1qib A - percentage of sequence identity: 83
830c A - percentage of sequence identity: 61