PDB: 1gz3 Compound: nad-dependent malic enzyme Classification: OXIDOREDUCTASE Entry date in PDB: 2003-05-22 Resolution [Å]: 2.30 R-Factor: 0.194

CHAIN: A SWISS-PROT/TREMBL: P23368    KEYWORD: 3D-structure    Mitochondrion    NAD    Oxidoreductase    Transit peptide    EC: 1.1.1.38 SCOP: c.2.1.7 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Aminoacid dehydrogenase-like, C-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) SCOP: c.58.1.3 Alpha and beta proteins (a/b)    Aminoacid dehydrogenase-like, N-terminal domain    Aminoacid dehydrogenase-like, N-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) GO:  malic enzyme activity    malate metabolism    CHAIN: B SWISS-PROT/TREMBL: P23368    KEYWORD: 3D-structure    Mitochondrion    NAD    Oxidoreductase    Transit peptide    EC: 1.1.1.38 SCOP: c.2.1.7 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Aminoacid dehydrogenase-like, C-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) SCOP: c.58.1.3 Alpha and beta proteins (a/b)    Aminoacid dehydrogenase-like, N-terminal domain    Aminoacid dehydrogenase-like, N-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) GO:  malic enzyme activity    malate metabolism    CHAIN: C SWISS-PROT/TREMBL: P23368    KEYWORD: 3D-structure    Mitochondrion    NAD    Oxidoreductase    Transit peptide    EC: 1.1.1.38 SCOP: c.2.1.7 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Aminoacid dehydrogenase-like, C-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) SCOP: c.58.1.3 Alpha and beta proteins (a/b)    Aminoacid dehydrogenase-like, N-terminal domain    Aminoacid dehydrogenase-like, N-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) GO:  malic enzyme activity    malate metabolism    CHAIN: D SWISS-PROT/TREMBL: P23368    KEYWORD: 3D-structure    Mitochondrion    NAD    Oxidoreductase    Transit peptide    EC: 1.1.1.38 SCOP: c.2.1.7 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Aminoacid dehydrogenase-like, C-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) SCOP: c.58.1.3 Alpha and beta proteins (a/b)    Aminoacid dehydrogenase-like, N-terminal domain    Aminoacid dehydrogenase-like, N-terminal domain    Mitochondrial NAD(P)-dependent malic enzyme    Mitochondrial NAD(P)-dependent malic enzyme    Human (Homo sapiens) GO:  malic enzyme activity    malate metabolism

Image Source: PDB

Loops in ArchDB40 clusters

1gz3_A_341 - HA => SUBCLASS : 2.2.2
1gz3_A_452 - HA => SUBCLASS : 3.1.1
1gz3_A_307 - EH => SUBCLASS : 3.2.1
1gz3_A_78 - HH => SUBCLASS : 1.2.24
1gz3_A_488 - HH => SUBCLASS : 2.1.6
1gz3_A_314 - HH => SUBCLASS : 3.3.2
1gz3_A_61 - HH => SUBCLASS : 3.4.4
1gz3_A_471 - HH => SUBCLASS : 6.4.2

Loops in ArchDB95 clusters

1gz3_A_307 - EH => SUBCLASS : 3.5.1
1gz3_A_78 - HH => SUBCLASS : 1.2.32
1gz3_A_488 - HH => SUBCLASS : 2.1.4
1gz3_A_314 - HH => SUBCLASS : 3.2.1
1gz3_A_61 - HH => SUBCLASS : 3.5.1
1gz3_A_471 - HH => SUBCLASS : 6.21.1
1gz3_A_334 - HE => SUBCLASS : 0.1.2
1gz3_A_334 - HE => SUBCLASS : 0.1.3
1gz3_A_401 - HE => SUBCLASS : 2.3.1
1gz3_A_401 - HE => SUBCLASS : 2.3.11
1gz3_A_259 - HE => SUBCLASS : 2.6.12
1gz3_A_377 - HE => SUBCLASS : 3.1.1
1gz3_A_229 - HE => SUBCLASS : 4.16.1
1gz3_A_430 - HE => SUBCLASS : 4.23.2
1gz3_A_430 - HE => SUBCLASS : 4.23.3
1gz3_A_178 - HE => SUBCLASS : 6.2.6
1gz3_A_282 - HE => SUBCLASS : 6.7.1
1gz3_A_282 - HE => SUBCLASS : 7.16.1
1gz3_A_178 - HE => SUBCLASS : 8.1.1
1gz3_A_341 - HA => SUBCLASS : 2.2.2
1gz3_A_452 - HA => SUBCLASS : 3.1.1

Loops not clustered in ArchDB

1gz3_A_442 - AR
1gz3_A_459 - AR
1gz3_A_463 - EH
1gz3_A_415 - EH
1gz3_A_388 - EH
1gz3_A_348 - EH
1gz3_A_275 - EH
1gz3_A_251 - EH
1gz3_A_198 - EH
1gz3_A_157 - EH
1gz3_A_133 - EH
1gz3_A_123 - HE
1gz3_A_143 - HE
1gz3_A_504 - HH
1gz3_A_210 - HH
1gz3_A_115 - HH
1gz3_A_104 - HH
1gz3_A_93 - HH
1gz3_A_42 - HH
1gz3_A_27 - HH
1gz3_A_519 - HH

1do8 A - percentage of sequence identity: 99
1do8 B - percentage of sequence identity: 99
1do8 C - percentage of sequence identity: 99
1do8 D - percentage of sequence identity: 99
1efk A - percentage of sequence identity: 99
1efk B - percentage of sequence identity: 99
1efk C - percentage of sequence identity: 99
1efk D - percentage of sequence identity: 99
1efl A - percentage of sequence identity: 99
1efl B - percentage of sequence identity: 99
1efl C - percentage of sequence identity: 99
1efl D - percentage of sequence identity: 99
1gz3 A - percentage of sequence identity: 100
1gz3 B - percentage of sequence identity: 100
1gz3 C - percentage of sequence identity: 100
1gz3 D - percentage of sequence identity: 100
1gz4 A - percentage of sequence identity: 99
1gz4 B - percentage of sequence identity: 99
1gz4 C - percentage of sequence identity: 99
1gz4 D - percentage of sequence identity: 99
1pj2 A - percentage of sequence identity: 99
1pj2 B - percentage of sequence identity: 99
1pj2 C - percentage of sequence identity: 99
1pj2 D - percentage of sequence identity: 99
1pj3 A - percentage of sequence identity: 99
1pj3 B - percentage of sequence identity: 99
1pj3 C - percentage of sequence identity: 99
1pj3 D - percentage of sequence identity: 99
1pj4 A - percentage of sequence identity: 99
1pj4 B - percentage of sequence identity: 99
1pj4 C - percentage of sequence identity: 99
1pj4 D - percentage of sequence identity: 99
1pjl A - percentage of sequence identity: 99
1pjl B - percentage of sequence identity: 99
1pjl C - percentage of sequence identity: 99
1pjl D - percentage of sequence identity: 99
1pjl E - percentage of sequence identity: 99
1pjl F - percentage of sequence identity: 99
1pjl G - percentage of sequence identity: 99
1pjl H - percentage of sequence identity: 99
1qr6 A - percentage of sequence identity: 99
1qr6 B - percentage of sequence identity: 99