PDB: 1hcf Compound: neurotrophin-4 Classification: COMPLEX(TRANSFERASE/GROWTH FACTOR) Entry date in PDB: 2001-12-06 Resolution [Å]: 2.70 R-Factor: 0.218

CHAIN: A SWISS-PROT/TREMBL: P34130    KEYWORD: 3D-structure    Growth factor    Signal    SCOP: g.17.1.3 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Neurotrophin    Neurotrophin 4, NT4    Human (Homo sapiens) GO:  growth factor activity    CHAIN: B SWISS-PROT/TREMBL: P34130    KEYWORD: 3D-structure    Growth factor    Signal    SCOP: g.17.1.3 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Neurotrophin    Neurotrophin 4, NT4    Human (Homo sapiens) GO:  growth factor activity    CHAIN: X SWISS-PROT/TREMBL: Q16620    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Glycoprotein    Immunoglobulin domain    Leucine-rich repeat    Neurogenesis    Phosphorylation    Polymorphism    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    3D-structure    Alternative splicing    ATP-binding    Glycoprotein    Immunoglobulin domain    Leucine-rich repeat    Neurogenesis    Phosphorylation    Polymorphism    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.1.1.4 All beta proteins    Immunoglobulin-like beta-sandwich    Immunoglobulin    I set domains    Ligand binding domain of trkB receptor    Human (Homo sapiens) GO:  membrane    ATP binding    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway    CHAIN: Y SWISS-PROT/TREMBL: Q16620    KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Glycoprotein    Immunoglobulin domain    Leucine-rich repeat    Neurogenesis    Phosphorylation    Polymorphism    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    3D-structure    Alternative splicing    ATP-binding    Glycoprotein    Immunoglobulin domain    Leucine-rich repeat    Neurogenesis    Phosphorylation    Polymorphism    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.1.1.4 All beta proteins    Immunoglobulin-like beta-sandwich    Immunoglobulin    I set domains    Ligand binding domain of trkB receptor    Human (Homo sapiens) GO:  membrane    ATP binding    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway

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1wwb X - percentage of sequence identity: 99