PDB: 1hrt Compound: Alpha-thrombin complex with hirudin variant 1 Classification: HYDROLASE(SERINE PROTEINASE) Entry date in PDB: 1994-01-31 Resolution [Å]: 2.80 R-Factor: 0.155

CHAIN: H SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: I SWISS-PROT/TREMBL: P01050    KEYWORD: 3D-structure    Multigene family    Pharmaceutical    Serine protease inhibitor    Sulfation    SCOP: g.3.15.2 Small proteins    Knottins (small inhibitors, toxins, lectins)    Leech antihemostatic proteins    Hirudin-like    Hirudin    Leech (Hirudo medicinalis) GO:  serine-type endopeptidase inhibitor activity    CHAIN: L SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis

Image Source: PDB

1etr H - percentage of sequence identity: 100
1h8d H - percentage of sequence identity: 86
1jou B - percentage of sequence identity: 87
1ucy H - percentage of sequence identity: 100
1vr1 H - percentage of sequence identity: 84
2hnt F - percentage of sequence identity: 94
4htc I - percentage of sequence identity: 87
null nu - percentage of sequence identity: 0