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PDB code:
Information on 1hw9
PDB:
1hw9
Compound:
hmg-coa reductase
Classification:
OXIDOREDUCTASE
Entry date in PDB:
2001-05-11
Resolution [Å]:
2.33
R-Factor:
0.222
CHAIN:
A
SWISS-PROT/TREMBL:
P04035
KEYWORD:
3D-structure Alternative splicing Cholesterol biosynthesis Endoplasmic reticulum Glycoprotein NADP Oxidoreductase Peroxisome Polymorphism Transmembrane
EC:
1.1.1.34
SCOP:
d.58.20.1
Alpha and beta proteins (a+b)
Ferredoxin-like
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
GO:
endoplasmic reticulum membrane
integral to membrane
hydroxymethylglutaryl-CoA reductase (NADPH) activity
biosynthesis
lipid metabolism
CHAIN:
B
SWISS-PROT/TREMBL:
P04035
KEYWORD:
3D-structure Alternative splicing Cholesterol biosynthesis Endoplasmic reticulum Glycoprotein NADP Oxidoreductase Peroxisome Polymorphism Transmembrane
EC:
1.1.1.34
SCOP:
d.58.20.1
Alpha and beta proteins (a+b)
Ferredoxin-like
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
GO:
endoplasmic reticulum membrane
integral to membrane
hydroxymethylglutaryl-CoA reductase (NADPH) activity
biosynthesis
lipid metabolism
CHAIN:
C
SWISS-PROT/TREMBL:
P04035
KEYWORD:
3D-structure Alternative splicing Cholesterol biosynthesis Endoplasmic reticulum Glycoprotein NADP Oxidoreductase Peroxisome Polymorphism Transmembrane
EC:
1.1.1.34
SCOP:
d.58.20.1
Alpha and beta proteins (a+b)
Ferredoxin-like
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
GO:
endoplasmic reticulum membrane
integral to membrane
hydroxymethylglutaryl-CoA reductase (NADPH) activity
biosynthesis
lipid metabolism
CHAIN:
D
SWISS-PROT/TREMBL:
P04035
KEYWORD:
3D-structure Alternative splicing Cholesterol biosynthesis Endoplasmic reticulum Glycoprotein NADP Oxidoreductase Peroxisome Polymorphism Transmembrane
EC:
1.1.1.34
SCOP:
d.58.20.1
Alpha and beta proteins (a+b)
Ferredoxin-like
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
NAD-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
SCOP:
d.179.1.1
Alpha and beta proteins (a+b)
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Substrate-binding domain of HMG-CoA reductase
Human (Homo sapiens)
GO:
endoplasmic reticulum membrane
integral to membrane
hydroxymethylglutaryl-CoA reductase (NADPH) activity
biosynthesis
lipid metabolism
Image Source:
PDB
Homologous structures to 1hw9 classified in ArchDB
1dqa
A - percentage of sequence identity: 100
1hwl
A - percentage of sequence identity: 100