PDB: 1hwk Compound: hmg-coa reductase Classification: OXIDOREDUCTASE Entry date in PDB: 2001-05-11 Resolution [Å]: 2.22 R-Factor: 0.212

CHAIN: A SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism    CHAIN: B SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism    CHAIN: C SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism    CHAIN: D SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism

Image Source: PDB

1dqa A - percentage of sequence identity: 100
1hwl A - percentage of sequence identity: 100