PDB: 1hwl Compound: hmg-coa reductase Classification: OXIDOREDUCTASE Entry date in PDB: 2001-05-11 Resolution [Å]: 2.10 R-Factor: 0.219

CHAIN: A SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism    CHAIN: B SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism    CHAIN: C SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism    CHAIN: D SWISS-PROT/TREMBL: P04035    KEYWORD: 3D-structure    Alternative splicing    Cholesterol biosynthesis    Endoplasmic reticulum    Glycoprotein    NADP    Oxidoreductase    Peroxisome    Polymorphism    Transmembrane    EC: 1.1.1.34 SCOP: d.58.20.1 Alpha and beta proteins (a+b)    Ferredoxin-like    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    NAD-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) SCOP: d.179.1.1 Alpha and beta proteins (a+b)    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Substrate-binding domain of HMG-CoA reductase    Human (Homo sapiens) GO:  endoplasmic reticulum membrane    integral to membrane    hydroxymethylglutaryl-CoA reductase (NADPH) activity    biosynthesis    lipid metabolism

Image Source: PDB

Loops in ArchDB40 clusters

1hwl_A_657 - HE => SUBCLASS : 4.1.1
1hwl_A_612 - HE => SUBCLASS : 4.1.4
1hwl_A_538 - HA => SUBCLASS : 2.1.1
1hwl_A_538 - HA => SUBCLASS : 2.1.2
1hwl_A_630 - HA => SUBCLASS : 2.3.1
1hwl_A_593 - EH => SUBCLASS : 2.1.2
1hwl_A_593 - EH => SUBCLASS : 2.1.6
1hwl_A_593 - EH => SUBCLASS : 2.1.11
1hwl_A_549 - EH => SUBCLASS : 4.33.1
1hwl_A_549 - EH => SUBCLASS : 4.33.2
1hwl_A_599 - HH => SUBCLASS : 1.1.1
1hwl_A_599 - HH => SUBCLASS : 1.1.2
1hwl_A_599 - HH => SUBCLASS : 1.1.3
1hwl_A_714 - HH => SUBCLASS : 3.1.1
1hwl_A_714 - HH => SUBCLASS : 3.1.2
1hwl_A_753 - HH => SUBCLASS : 3.3.3

Loops in ArchDB95 clusters

1hwl_A_748 - EH => SUBCLASS : 0.1.57
1hwl_A_593 - EH => SUBCLASS : 2.1.6
1hwl_A_549 - EH => SUBCLASS : 4.36.1
1hwl_A_599 - HH => SUBCLASS : 1.1.1
1hwl_A_599 - HH => SUBCLASS : 1.1.2
1hwl_A_753 - HH => SUBCLASS : 3.1.1
1hwl_A_714 - HH => SUBCLASS : 3.4.1
1hwl_A_612 - HE => SUBCLASS : 3.4.7
1hwl_A_657 - HE => SUBCLASS : 4.1.1
1hwl_A_538 - HA => SUBCLASS : 2.1.1
1hwl_A_538 - HA => SUBCLASS : 2.1.3
1hwl_A_630 - HA => SUBCLASS : 2.3.1
1hwl_A_777 - HA => SUBCLASS : 5.14.1

Loops not clustered in ArchDB

1hwl_A_580 - AR
1hwl_A_642 - EH
1hwl_A_679 - EH
1hwl_A_703 - EH
1hwl_A_790 - EH
1hwl_A_771 - HE
1hwl_A_738 - HE
1hwl_A_695 - HE
1hwl_A_562 - HE
1hwl_A_519 - HE
1hwl_A_464 - HH
1hwl_A_488 - HH
1hwl_A_725 - HH
1hwl_A_812 - HH

1dq8 A - percentage of sequence identity: 100
1dq8 B - percentage of sequence identity: 100
1dq8 C - percentage of sequence identity: 100
1dq8 D - percentage of sequence identity: 100
1dq9 A - percentage of sequence identity: 100
1dq9 B - percentage of sequence identity: 100
1dq9 C - percentage of sequence identity: 100
1dq9 D - percentage of sequence identity: 100
1dqa A - percentage of sequence identity: 100
1dqa B - percentage of sequence identity: 100
1dqa C - percentage of sequence identity: 100
1dqa D - percentage of sequence identity: 100
1hw8 A - percentage of sequence identity: 100
1hw8 B - percentage of sequence identity: 100
1hw8 C - percentage of sequence identity: 100
1hw8 D - percentage of sequence identity: 100
1hw9 A - percentage of sequence identity: 100
1hw9 B - percentage of sequence identity: 100
1hw9 C - percentage of sequence identity: 100
1hw9 D - percentage of sequence identity: 100
1hwi A - percentage of sequence identity: 100
1hwi B - percentage of sequence identity: 100
1hwi C - percentage of sequence identity: 100
1hwi D - percentage of sequence identity: 100
1hwj A - percentage of sequence identity: 100
1hwj B - percentage of sequence identity: 100
1hwj C - percentage of sequence identity: 100
1hwj D - percentage of sequence identity: 100
1hwk A - percentage of sequence identity: 100
1hwk B - percentage of sequence identity: 100
1hwk C - percentage of sequence identity: 100
1hwk D - percentage of sequence identity: 100
1hwl A - percentage of sequence identity: 100
1hwl B - percentage of sequence identity: 100
1hwl C - percentage of sequence identity: 100
1hwl D - percentage of sequence identity: 100