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Information on 1is8
PDB: 1is8
Compound: gtp cyclohydrolase i
Classification: HYDROLASE/PROTEIN BINDING
Entry date in PDB: 2002-02-20
Resolution [Å]: 2.70
R-Factor: 0.219


CHAIN: A
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: B
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: C
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: D
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: E
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: F
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: G
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: H
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: I
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: J
SWISS-PROT/TREMBL: P22288
   KEYWORD: 3D-structure    Allosteric enzyme    Hydrolase    Tetrahydrobiopterin biosynthesis   
EC: 3.5.4.16
SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Rat (Rattus norvegicus)
GO:  GTP cyclohydrolase I activity    biosynthesis   


CHAIN: K
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: L
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: M
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: N
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: O
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: P
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: Q
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: R
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: S
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  


CHAIN: T
SWISS-PROT/TREMBL: P70552
   KEYWORD: 3D-structure   
SCOP: d.205.1.1 Alpha and beta proteins (a+b)    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    GTP cyclohydrolase I feedback regulatory protein, GFRP    Rat (Rattus norvegicus)
GO:  
 1is8 Image
Image Source: PDB

Stored Loops of 1is8

Loops in ArchDB-EC clusters

1is8_A_151 - EH => SUBCLASS : 3.4.1

Loops not clustered in ArchDB

1is8_A_138 - AR
1is8_A_114 - AR
1is8_A_170 - EH
1is8_A_192 - EH
1is8_A_216 - EH
1is8_A_121 - HA
1is8_A_105 - HE
1is8_A_202 - HE
1is8_A_173 - HE
1is8_A_156 - HE
1is8_A_52 - HH
1is8_A_224 - HH
1is8_A_85 - HH

Homologous structures to 1is8 classified in ArchDB

1fb1 A - percentage of sequence identity: 96
1fb1 B - percentage of sequence identity: 96
1fb1 C - percentage of sequence identity: 96
1fb1 D - percentage of sequence identity: 96
1fb1 E - percentage of sequence identity: 96
1is7 A - percentage of sequence identity: 100
1is7 B - percentage of sequence identity: 100
1is7 C - percentage of sequence identity: 100
1is7 D - percentage of sequence identity: 100
1is7 E - percentage of sequence identity: 100
1is7 F - percentage of sequence identity: 100
1is7 G - percentage of sequence identity: 100
1is7 H - percentage of sequence identity: 100
1is7 I - percentage of sequence identity: 100
1is7 J - percentage of sequence identity: 100
1is8 A - percentage of sequence identity: 100
1is8 B - percentage of sequence identity: 100
1is8 C - percentage of sequence identity: 100
1is8 D - percentage of sequence identity: 100
1is8 E - percentage of sequence identity: 100
1is8 F - percentage of sequence identity: 100
1is8 G - percentage of sequence identity: 100
1is8 H - percentage of sequence identity: 100
1is8 I - percentage of sequence identity: 100
1is8 J - percentage of sequence identity: 100
1wpl A - percentage of sequence identity: 100
1wpl B - percentage of sequence identity: 100
1wpl C - percentage of sequence identity: 100
1wpl D - percentage of sequence identity: 100
1wpl E - percentage of sequence identity: 100
1wpl F - percentage of sequence identity: 100
1wpl G - percentage of sequence identity: 100
1wpl H - percentage of sequence identity: 100
1wpl I - percentage of sequence identity: 100
1wpl J - percentage of sequence identity: 100
null nu - percentage of sequence identity: 0