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Information on 1j3k
PDB: 1j3k
Compound: bifunctional dihydrofolate reductase-thymidylate s
Classification: OXIDOREDUCTASE, TRANSFERASE
Entry date in PDB: 2003-05-06
Resolution [Å]: 2.10
R-Factor: 0.182


CHAIN: A
SWISS-PROT/TREMBL: P13922
   KEYWORD: 3D-structure    Methyltransferase    Multifunctional enzyme    NADP    Nucleotide biosynthesis    One-carbon metabolism    Oxidoreductase    Transferase   
EC: 1.5.1.3
SCOP: c.71.1.1 Alpha and beta proteins (a/b)    Dihydrofolate reductases    Dihydrofolate reductases    Dihydrofolate reductases    Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain    Malaria parasite (Plasmodium falciparum)
GO:  dihydrofolate reductase activity    thymidylate synthase activity    dTMP biosynthesis    glycine biosynthesis    nucleotide biosynthesis   


CHAIN: B
SWISS-PROT/TREMBL: P13922
   KEYWORD: 3D-structure    Methyltransferase    Multifunctional enzyme    NADP    Nucleotide biosynthesis    One-carbon metabolism    Oxidoreductase    Transferase   
EC: 1.5.1.3
SCOP: c.71.1.1 Alpha and beta proteins (a/b)    Dihydrofolate reductases    Dihydrofolate reductases    Dihydrofolate reductases    Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain    Malaria parasite (Plasmodium falciparum)
GO:  dihydrofolate reductase activity    thymidylate synthase activity    dTMP biosynthesis    glycine biosynthesis    nucleotide biosynthesis   


CHAIN: C
SWISS-PROT/TREMBL: P13922
   KEYWORD: 3D-structure    Methyltransferase    Multifunctional enzyme    NADP    Nucleotide biosynthesis    One-carbon metabolism    Oxidoreductase    Transferase   
EC: 1.5.1.3
SCOP: d.117.1.1 Alpha and beta proteins (a+b)    Thymidylate synthase/dCMP hydroxymethylase    Thymidylate synthase/dCMP hydroxymethylase    Thymidylate synthase/dCMP hydroxymethylase    Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain    Malaria parasite (Plasmodium falciparum)
GO:  dihydrofolate reductase activity    thymidylate synthase activity    dTMP biosynthesis    glycine biosynthesis    nucleotide biosynthesis   


CHAIN: D
SWISS-PROT/TREMBL: P13922
   KEYWORD: 3D-structure    Methyltransferase    Multifunctional enzyme    NADP    Nucleotide biosynthesis    One-carbon metabolism    Oxidoreductase    Transferase   
EC: 1.5.1.3
SCOP: d.117.1.1 Alpha and beta proteins (a+b)    Thymidylate synthase/dCMP hydroxymethylase    Thymidylate synthase/dCMP hydroxymethylase    Thymidylate synthase/dCMP hydroxymethylase    Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain    Malaria parasite (Plasmodium falciparum)
GO:  dihydrofolate reductase activity    thymidylate synthase activity    dTMP biosynthesis    glycine biosynthesis    nucleotide biosynthesis   
1j3k Image
Image Source: PDB

Stored Loops of 1j3k

Loops in ArchDB95 clusters

1j3k_C_539 - EH => SUBCLASS : 0.1.23
1j3k_C_502 - EH => SUBCLASS : 1.2.10
1j3k_C_377 - HH => SUBCLASS : 4.5.1
1j3k_C_430 - HH => SUBCLASS : 18.2.1
1j3k_C_325 - HE => SUBCLASS : 0.1.1
1j3k_C_517 - HE => SUBCLASS : 1.2.17
1j3k_C_557 - HE => SUBCLASS : 7.7.1
1j3k_C_340 - HA => SUBCLASS : 7.29.1
1j3k_C_573 - HA => SUBCLASS : 14.6.1
1j3k_C_473 - HA => SUBCLASS : 15.1.1

Loops in ArchDB-EC clusters

1j3k_C_430 - HH => SUBCLASS : 18.1.1

Loops not clustered in ArchDB

1j3k_C_350 - EH
1j3k_C_491 - HA
1j3k_C_473 - HA
1j3k_C_340 - HA
1j3k_C_491 - HA
1j3k_C_573 - HA
1j3k_C_455 - HE
1j3k_C_393 - HH
1j3k_C_313 - HH
1j3k_C_285 - HH
1j3k_C_410 - HH

Homologous structures to 1j3k classified in ArchDB

1j3i C - percentage of sequence identity: 100
1j3i D - percentage of sequence identity: 100
1j3j C - percentage of sequence identity: 100
1j3j D - percentage of sequence identity: 100
1j3k C - percentage of sequence identity: 100
1j3k D - percentage of sequence identity: 100