PDB: 1kz7 Compound: guanine nucleotide exchange factor dbs Classification: SIGNALING PROTEIN Entry date in PDB: 2002-03-20 Resolution [Å]: 2.40 R-Factor: 0.197

CHAIN: A SWISS-PROT/TREMBL: Q64096    KEYWORD: 3D-structure    Guanine-nucleotide releasing factor    Proto-oncogene    SH3 domain    SCOP: a.87.1.1 All alpha proteins    DBL homology domain (DH-domain)    DBL homology domain (DH-domain)    DBL homology domain (DH-domain)    Dbl's big sister, Dbs    Mouse (Mus musculus) SCOP: b.55.1.1 All beta proteins    PH domain-like    PH domain-like    Pleckstrin-homology domain (PH domain)    Dbl's big sister, Dbs    Mouse (Mus musculus) GO:  guanyl-nucleotide exchange factor activity    intracellular signaling cascade    CHAIN: B SWISS-PROT/TREMBL: P60953    KEYWORD: 3D-structure    Alternative splicing    GTP-binding    Lipoprotein    Methylation    Prenylation    SCOP: c.37.1.8 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    G proteins    CDC42    Human (Homo sapiens) GO:  GTP binding    protein transport    small GTPase mediated signal transduction    CHAIN: C SWISS-PROT/TREMBL: Q64096    KEYWORD: 3D-structure    Guanine-nucleotide releasing factor    Proto-oncogene    SH3 domain    SCOP: a.87.1.1 All alpha proteins    DBL homology domain (DH-domain)    DBL homology domain (DH-domain)    DBL homology domain (DH-domain)    Dbl's big sister, Dbs    Mouse (Mus musculus) SCOP: b.55.1.1 All beta proteins    PH domain-like    PH domain-like    Pleckstrin-homology domain (PH domain)    Dbl's big sister, Dbs    Mouse (Mus musculus) GO:  guanyl-nucleotide exchange factor activity    intracellular signaling cascade    CHAIN: D SWISS-PROT/TREMBL: P60953    KEYWORD: 3D-structure    Alternative splicing    GTP-binding    Lipoprotein    Methylation    Prenylation    SCOP: c.37.1.8 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    G proteins    CDC42    Human (Homo sapiens) GO:  GTP binding    protein transport    small GTPase mediated signal transduction

Image Source: PDB

Loops in ArchDB40 clusters

1kz7_A_861 - HA => SUBCLASS : 2.2.1
1kz7_A_912 - HA => SUBCLASS : 4.6.1
1kz7_A_922 - EH => SUBCLASS : 2.1.2
1kz7_A_746 - HH => SUBCLASS : 5.28.1

Loops in ArchDB95 clusters

1kz7_A_922 - EH => SUBCLASS : 2.1.3
1kz7_A_861 - HA => SUBCLASS : 2.2.1
1kz7_A_912 - HA => SUBCLASS : 4.6.1

Loops not clustered in ArchDB

1kz7_A_818 - AR
1kz7_A_888 - AR
1kz7_A_835 - HA
1kz7_A_870 - HA
1kz7_A_900 - HA
1kz7_A_792 - HE
1kz7_A_761 - HH
1kz7_A_724 - HH
1kz7_A_711 - HH
1kz7_A_697 - HH
1kz7_A_688 - HH
1kz7_A_679 - HH
1kz7_A_673 - HH
1kz7_A_639 - HH
1kz7_A_625 - HH
1kz7_A_767 - HH

1kz7 A - percentage of sequence identity: 100
1kz7 C - percentage of sequence identity: 100
1kzg A - percentage of sequence identity: 99
1kzg C - percentage of sequence identity: 99
1lb1 A - percentage of sequence identity: 99
1lb1 C - percentage of sequence identity: 99
1lb1 E - percentage of sequence identity: 99
1lb1 G - percentage of sequence identity: 99
1rj2 A - percentage of sequence identity: 99
1rj2 D - percentage of sequence identity: 99
1rj2 G - percentage of sequence identity: 99
1rj2 J - percentage of sequence identity: 99
1ryh A - percentage of sequence identity: 65
2ngr A - percentage of sequence identity: 100