PDB: 1liw Compound: pyruvate kinase, isozymes rL Classification: TRANSFERASE Entry date in PDB: 2002-09-11 Resolution [Å]: 2.75 R-Factor: 0.247

CHAIN: A SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: B SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: C SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: D SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis

Image Source: PDB

1a49 A - percentage of sequence identity: 68
1aqf E - percentage of sequence identity: 68
1liu A - percentage of sequence identity: 99
1lix B - percentage of sequence identity: 99