PDB: 1lyw Compound: cathepsin d Classification: ASPARTIC PROTEASE Entry date in PDB: 1999-07-22 Resolution [Å]: 2.50 R-Factor: 0.195

CHAIN: A SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: E SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: F SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: G SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: H SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis

Image Source: PDB

1dpj A - percentage of sequence identity: 60
1lya B - percentage of sequence identity: 100
1qdm A - percentage of sequence identity: 63
1smr A - percentage of sequence identity: 63