PDB: 1nb5 Compound: cathepsin h Classification: HYDROLASE Entry date in PDB: 2003-02-18 Resolution [Å]: 2.40 R-Factor: 0.235

CHAIN: A SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:  cysteine-type endopeptidase activity    cysteine-type peptidase activity    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:  cysteine-type endopeptidase activity    cysteine-type peptidase activity    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:  cysteine-type endopeptidase activity    cysteine-type peptidase activity    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:  cysteine-type endopeptidase activity    cysteine-type peptidase activity    proteolysis and peptidolysis    CHAIN: I SWISS-PROT/TREMBL: P01040    KEYWORD: 3D-structure    Thiol protease inhibitor    SCOP: d.17.1.2 Alpha and beta proteins (a+b)    Cystatin-like    Cystatin/monellin    Cystatins    Cystatin A (stefin A)    Human (Homo sapiens) GO:  intracellular    cysteine protease inhibitor activity    endopeptidase inhibitor activity    CHAIN: J SWISS-PROT/TREMBL: P01040    KEYWORD: 3D-structure    Thiol protease inhibitor    SCOP: d.17.1.2 Alpha and beta proteins (a+b)    Cystatin-like    Cystatin/monellin    Cystatins    Cystatin A (stefin A)    Human (Homo sapiens) GO:  intracellular    cysteine protease inhibitor activity    endopeptidase inhibitor activity    CHAIN: K SWISS-PROT/TREMBL: P01040    KEYWORD: 3D-structure    Thiol protease inhibitor    SCOP: d.17.1.2 Alpha and beta proteins (a+b)    Cystatin-like    Cystatin/monellin    Cystatins    Cystatin A (stefin A)    Human (Homo sapiens) GO:  intracellular    cysteine protease inhibitor activity    endopeptidase inhibitor activity    CHAIN: L SWISS-PROT/TREMBL: P01040    KEYWORD: 3D-structure    Thiol protease inhibitor    SCOP: d.17.1.2 Alpha and beta proteins (a+b)    Cystatin-like    Cystatin/monellin    Cystatins    Cystatin A (stefin A)    Human (Homo sapiens) GO:  intracellular    cysteine protease inhibitor activity    endopeptidase inhibitor activity    CHAIN: P SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:   CHAIN: R SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:   CHAIN: S SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:   CHAIN: T SWISS-PROT/TREMBL: O46427    KEYWORD: 3D-structure    Glycoprotein    Hydrolase    Lysosome    Signal    Thiol protease    Zymogen    EC: 3.4.22.16 SCOP: d.3.1.1 Alpha and beta proteins (a+b)    Cysteine proteinases    Cysteine proteinases    Papain-like    Cathepsin H    Pig (Sus scrofa) GO:

Image Source: PDB

Loops in ArchDB95 clusters

1nb5_I_15 - EH => SUBCLASS : 2.4.15

Loops not clustered in ArchDB

1nb5_I_46 - HA
1nb5_I_57 - HA
1nb5_I_94 - HA
1nb5_I_19 - HE

1cyu - - percentage of sequence identity: 98
1cyv - - percentage of sequence identity: 98
1dvc - - percentage of sequence identity: 100
1dvd - - percentage of sequence identity: 100
1gd3 A - percentage of sequence identity: 98
1gd4 A - percentage of sequence identity: 97
1n9j A - percentage of sequence identity: 100
1n9j B - percentage of sequence identity: 100
1nb3 I - percentage of sequence identity: 100
1nb3 J - percentage of sequence identity: 100
1nb3 K - percentage of sequence identity: 100
1nb3 L - percentage of sequence identity: 100
1nb5 I - percentage of sequence identity: 100
1nb5 J - percentage of sequence identity: 100
1nb5 K - percentage of sequence identity: 100
1nb5 L - percentage of sequence identity: 100
8pch A - percentage of sequence identity: 100