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Information on 1ni4
PDB: 1ni4
Compound: pyruvate dehydrogenase e1 component
Classification: OXIDOREDUCTASE
Entry date in PDB: 2003-06-17
Resolution [Å]: 1.95
R-Factor: 0.202


CHAIN: A
SWISS-PROT/TREMBL: P08559
   KEYWORD: 3D-structure    Disease mutation    Flavoprotein    Glycolysis    Leigh syndrome    Mitochondrion    Multigene family    Oxidoreductase    Phosphorylation    Thiamine pyrophosphate    Transit peptide    3D-structure    Disease mutation    Flavoprotein    Glycolysis    Leigh syndrome    Mitochondrion    Multigene family    Oxidoreductase    Phosphorylation    Thiamine pyrophosphate    Transit peptide   
EC: 1.2.4.1
SCOP: c.36.1.11 Alpha and beta proteins (a/b)    Thiamin diphosphate-binding fold (THDP-binding)    Thiamin diphosphate-binding fold (THDP-binding)    Branched-chain alpha-keto acid dehydrogenase PP module    E1-beta subunit of pyruvate dehydrogenase (PP module)    Human (Homo sapiens)
GO:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor    metabolism   


CHAIN: B
SWISS-PROT/TREMBL: P11177
   KEYWORD: 3D-structure    Flavoprotein    Glycolysis    Mitochondrion    Oxidoreductase    Polymorphism    Thiamine pyrophosphate    Transit peptide    3D-structure    Flavoprotein    Glycolysis    Mitochondrion    Oxidoreductase    Polymorphism    Thiamine pyrophosphate    Transit peptide   
EC: 1.2.4.1
SCOP: c.36.1.7 Alpha and beta proteins (a/b)    Thiamin diphosphate-binding fold (THDP-binding)    Thiamin diphosphate-binding fold (THDP-binding)    Branched-chain alpha-keto acid dehydrogenase Pyr module    E1-beta subunit of pyruvate dehydrogenase, Pyr module    Human (Homo sapiens)
SCOP: c.48.1.2 Alpha and beta proteins (a/b)    TK C-terminal domain-like    TK C-terminal domain-like    Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain    E1-beta subunit of pyruvate dehydrogenase, C-domain    Human (Homo sapiens)
GO:  


CHAIN: C
SWISS-PROT/TREMBL: P08559
   KEYWORD: 3D-structure    Disease mutation    Flavoprotein    Glycolysis    Leigh syndrome    Mitochondrion    Multigene family    Oxidoreductase    Phosphorylation    Thiamine pyrophosphate    Transit peptide    3D-structure    Disease mutation    Flavoprotein    Glycolysis    Leigh syndrome    Mitochondrion    Multigene family    Oxidoreductase    Phosphorylation    Thiamine pyrophosphate    Transit peptide   
EC: 1.2.4.1
SCOP: c.36.1.11 Alpha and beta proteins (a/b)    Thiamin diphosphate-binding fold (THDP-binding)    Thiamin diphosphate-binding fold (THDP-binding)    Branched-chain alpha-keto acid dehydrogenase PP module    E1-beta subunit of pyruvate dehydrogenase (PP module)    Human (Homo sapiens)
GO:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor    metabolism   


CHAIN: D
SWISS-PROT/TREMBL: P11177
   KEYWORD: 3D-structure    Flavoprotein    Glycolysis    Mitochondrion    Oxidoreductase    Polymorphism    Thiamine pyrophosphate    Transit peptide    3D-structure    Flavoprotein    Glycolysis    Mitochondrion    Oxidoreductase    Polymorphism    Thiamine pyrophosphate    Transit peptide   
EC: 1.2.4.1
SCOP: c.36.1.7 Alpha and beta proteins (a/b)    Thiamin diphosphate-binding fold (THDP-binding)    Thiamin diphosphate-binding fold (THDP-binding)    Branched-chain alpha-keto acid dehydrogenase Pyr module    E1-beta subunit of pyruvate dehydrogenase, Pyr module    Human (Homo sapiens)
SCOP: c.48.1.2 Alpha and beta proteins (a/b)    TK C-terminal domain-like    TK C-terminal domain-like    Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain    E1-beta subunit of pyruvate dehydrogenase, C-domain    Human (Homo sapiens)
GO:  
1ni4 Image
Image Source: PDB

Stored Loops of 1ni4

Loops in ArchDB40 clusters

1ni4_A_346 - HA => SUBCLASS : 4.3.1
1ni4_B_179 - EH => SUBCLASS : 1.1.6
1ni4_B_207 - EH => SUBCLASS : 1.2.6
1ni4_B_143 - EH => SUBCLASS : 4.12.2
1ni4_B_143 - EH => SUBCLASS : 4.15.2
1ni4_A_161 - EH => SUBCLASS : 6.3.2
1ni4_B_200 - AR => SUBCLASS : 4.15.1
1ni4_A_92 - HH => SUBCLASS : 3.3.1

Loops in ArchDB95 clusters

1ni4_B_179 - EH => SUBCLASS : 1.1.6
1ni4_B_207 - EH => SUBCLASS : 1.3.5
1ni4_B_143 - EH => SUBCLASS : 4.5.1
1ni4_A_161 - EH => SUBCLASS : 6.3.1
1ni4_A_161 - EH => SUBCLASS : 6.3.2
1ni4_B_23 - EH => SUBCLASS : 15.7.1
1ni4_B_200 - AR => SUBCLASS : 4.12.3
1ni4_A_92 - HH => SUBCLASS : 3.2.1
1ni4_B_215 - HE => SUBCLASS : 2.1.1
1ni4_B_150 - HE => SUBCLASS : 2.2.2
1ni4_B_15 - HE => SUBCLASS : 3.4.1
1ni4_B_133 - HE => SUBCLASS : 3.7.1
1ni4_B_133 - HE => SUBCLASS : 3.10.1
1ni4_B_43 - HE => SUBCLASS : 4.10.1
1ni4_A_141 - HE => SUBCLASS : 4.40.1
1ni4_A_69 - HE => SUBCLASS : 5.1.1
1ni4_A_346 - HA => SUBCLASS : 4.2.1
1ni4_A_346 - HA => SUBCLASS : 4.2.3

Loops in ArchDB-EC clusters

1ni4_A_92 - HH => SUBCLASS : 3.2.1

Loops not clustered in ArchDB

1ni4_B_233 - AR
1ni4_B_167 - AR
1ni4_B_233 - AR
1ni4_A_4 - AR
1ni4_A_13 - AR
1ni4_A_4 - AR
1ni4_A_13 - AR
1ni4_B_167 - AR
1ni4_B_200 - AR
1ni4_A_24 - EH
1ni4_B_293 - EH
1ni4_B_259 - EH
1ni4_B_113 - EH
1ni4_B_75 - EH
1ni4_B_52 - EH
1ni4_B_240 - EH
1ni4_B_2 - EH
1ni4_A_255 - EH
1ni4_A_222 - EH
1ni4_A_189 - EH
1ni4_A_84 - EH
1ni4_A_346 - HA
1ni4_B_184 - HE
1ni4_B_90 - HE
1ni4_A_173 - HE
1ni4_A_204 - HE
1ni4_A_230 - HE
1ni4_A_303 - HE
1ni4_B_271 - HE
1ni4_B_248 - HE
1ni4_B_62 - HE
1ni4_A_102 - HH
1ni4_A_29 - HH
1ni4_B_306 - HH
1ni4_B_5 - HH
1ni4_A_47 - HH
1ni4_A_275 - HH

Homologous structures to 1ni4 classified in ArchDB

1ni4 A - percentage of sequence identity: 100
1ni4 C - percentage of sequence identity: 100