PDB: 1p8j Compound: furin precursor Classification: HYDROLASE Entry date in PDB: 2003-07-08 Resolution [Å]: 2.60 R-Factor: 0.188

CHAIN: A SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: E SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: F SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: G SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis    CHAIN: H SWISS-PROT/TREMBL: P23188    KEYWORD: 3D-structure    Autocatalytic cleavage    Calcium    Glycoprotein    Hydrolase    Serine protease    Signal    Transmembrane    Zymogen    EC: 3.4.21.75 SCOP: b.18.1.20 All beta proteins    Galactose-binding domain-like    Galactose-binding domain-like    Proprotein convertase P-domain    Furin, C-terminal domain    Mouse (Mus musculus) SCOP: c.41.1.1 Alpha and beta proteins (a/b)    Subtilisin-like    Subtilisin-like    Subtilases    Furin, N-terminal domain    Mouse (Mus musculus) GO:  subtilase activity    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB-EC clusters

1p8j_A_367 - HH => SUBCLASS : 5.2.1

Loops not clustered in ArchDB

1p8j_A_545 - AR
1p8j_A_338 - AR
1p8j_A_448 - AR
1p8j_A_459 - AR
1p8j_A_464 - AR
1p8j_A_483 - AR
1p8j_A_512 - AR
1p8j_A_528 - AR
1p8j_A_148 - AR
1p8j_A_173 - EH
1p8j_A_220 - EH
1p8j_A_249 - EH
1p8j_A_359 - EH
1p8j_A_419 - EH
1p8j_A_288 - HA
1p8j_A_314 - HA
1p8j_A_501 - HA
1p8j_A_351 - HA
1p8j_A_412 - HA
1p8j_A_135 - HE
1p8j_A_194 - HE
1p8j_A_233 - HE
1p8j_A_268 - HE
1p8j_A_390 - HE
1p8j_A_431 - HE

1p8j A - percentage of sequence identity: 100
1p8j B - percentage of sequence identity: 100
1p8j C - percentage of sequence identity: 100
1p8j D - percentage of sequence identity: 100
1p8j E - percentage of sequence identity: 100
1p8j F - percentage of sequence identity: 100
1p8j G - percentage of sequence identity: 100
1p8j H - percentage of sequence identity: 100