PDB: 1pkx Compound: bifunctional purine biosynthesis protein purh Classification: TRANSFERASE, HYDROLASE Entry date in PDB: 2004-02-17 Resolution [Å]: 1.90 R-Factor: 0.211

CHAIN: A SWISS-PROT/TREMBL: P31939    KEYWORD: Hydrolase    Multifunctional enzyme    Purine biosynthesis    Transferase    EC: 2.1.2.3 SCOP: c.24.1.3 Alpha and beta proteins (a/b)    Methylglyoxal synthase-like    Methylglyoxal synthase-like    Inosicase    IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) SCOP: c.97.2.1 Alpha and beta proteins (a/b)    Cytidine deaminase-like    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) GO:  IMP cyclohydrolase activity    phosphoribosylaminoimidazolecarboxamide formyltransferase activity    purine nucleotide biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P31939    KEYWORD: Hydrolase    Multifunctional enzyme    Purine biosynthesis    Transferase    EC: 2.1.2.3 SCOP: c.24.1.3 Alpha and beta proteins (a/b)    Methylglyoxal synthase-like    Methylglyoxal synthase-like    Inosicase    IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) SCOP: c.97.2.1 Alpha and beta proteins (a/b)    Cytidine deaminase-like    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) GO:  IMP cyclohydrolase activity    phosphoribosylaminoimidazolecarboxamide formyltransferase activity    purine nucleotide biosynthesis    CHAIN: C SWISS-PROT/TREMBL: P31939    KEYWORD: Hydrolase    Multifunctional enzyme    Purine biosynthesis    Transferase    EC: 2.1.2.3 SCOP: c.24.1.3 Alpha and beta proteins (a/b)    Methylglyoxal synthase-like    Methylglyoxal synthase-like    Inosicase    IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) SCOP: c.97.2.1 Alpha and beta proteins (a/b)    Cytidine deaminase-like    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) GO:  IMP cyclohydrolase activity    phosphoribosylaminoimidazolecarboxamide formyltransferase activity    purine nucleotide biosynthesis    CHAIN: D SWISS-PROT/TREMBL: P31939    KEYWORD: Hydrolase    Multifunctional enzyme    Purine biosynthesis    Transferase    EC: 2.1.2.3 SCOP: c.24.1.3 Alpha and beta proteins (a/b)    Methylglyoxal synthase-like    Methylglyoxal synthase-like    Inosicase    IMP cyclohydrolase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) SCOP: c.97.2.1 Alpha and beta proteins (a/b)    Cytidine deaminase-like    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC    Human (Homo sapiens) GO:  IMP cyclohydrolase activity    phosphoribosylaminoimidazolecarboxamide formyltransferase activity    purine nucleotide biosynthesis

Image Source: PDB

Loops in ArchDB95 clusters

1pkx_A_143 - EH => SUBCLASS : 2.1.15
1pkx_A_143 - EH => SUBCLASS : 2.1.22
1pkx_A_96 - EH => SUBCLASS : 4.19.3
1pkx_A_228 - EH => SUBCLASS : 4.65.1
1pkx_A_317 - EH => SUBCLASS : 5.4.1
1pkx_A_440 - EH => SUBCLASS : 5.13.1
1pkx_A_451 - HH => SUBCLASS : 1.1.9
1pkx_A_117 - HH => SUBCLASS : 2.1.54
1pkx_A_17 - HE => SUBCLASS : 1.1.1
1pkx_A_568 - HE => SUBCLASS : 1.1.1
1pkx_A_546 - HE => SUBCLASS : 1.1.2
1pkx_A_546 - HE => SUBCLASS : 1.1.3
1pkx_A_35 - HE => SUBCLASS : 2.1.1
1pkx_A_237 - HE => SUBCLASS : 3.2.12
1pkx_A_82 - HE => SUBCLASS : 4.5.2
1pkx_A_35 - HE => SUBCLASS : 4.53.1
1pkx_A_376 - HA => SUBCLASS : 2.1.1

Loops not clustered in ArchDB

1pkx_A_217 - AR
1pkx_A_363 - AR
1pkx_A_269 - EH
1pkx_A_384 - EH
1pkx_A_49 - EH
1pkx_A_30 - EH
1pkx_A_6 - EH
1pkx_A_534 - EH
1pkx_A_556 - EH
1pkx_A_338 - EH
1pkx_A_203 - HA
1pkx_A_433 - HA
1pkx_A_261 - HA
1pkx_A_521 - HE
1pkx_A_412 - HE
1pkx_A_348 - HE
1pkx_A_327 - HE
1pkx_A_298 - HE
1pkx_A_168 - HE
1pkx_A_127 - HE
1pkx_A_486 - HH
1pkx_A_471 - HH
1pkx_A_281 - HH
1pkx_A_151 - HH
1pkx_A_106 - HH
1pkx_A_70 - HH
1pkx_A_51 - HH
1pkx_A_503 - HH

1g8m A - percentage of sequence identity: 83
1g8m B - percentage of sequence identity: 83
1m9n A - percentage of sequence identity: 83
1m9n B - percentage of sequence identity: 83
1oz0 A - percentage of sequence identity: 83
1oz0 B - percentage of sequence identity: 83
1p4r A - percentage of sequence identity: 100
1p4r B - percentage of sequence identity: 100
1pkx A - percentage of sequence identity: 100
1pkx B - percentage of sequence identity: 100
1pkx C - percentage of sequence identity: 100
1pkx D - percentage of sequence identity: 100
1pl0 A - percentage of sequence identity: 100
1pl0 B - percentage of sequence identity: 100
1pl0 C - percentage of sequence identity: 100
1pl0 D - percentage of sequence identity: 100
1thz A - percentage of sequence identity: 83
1thz B - percentage of sequence identity: 83