PDB: 1pn2 Compound: peroxisomal hydratase-dehydrogenase-epimerase Classification: LYASE Entry date in PDB: 2004-04-13 Resolution [Å]: 1.95 R-Factor: 0.182

CHAIN: A SWISS-PROT/TREMBL: P22414    KEYWORD: Fatty acid metabolism    Isomerase    Lyase    Multifunctional enzyme    NAD    Oxidoreductase    Peroxisome    Repeat    EC: 4.2.1.- SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) GO:  fatty acid synthase complex    fatty-acid synthase activity    oxidoreductase activity    fatty acid biosynthesis    metabolism    CHAIN: B SWISS-PROT/TREMBL: P22414    KEYWORD: Fatty acid metabolism    Isomerase    Lyase    Multifunctional enzyme    NAD    Oxidoreductase    Peroxisome    Repeat    EC: 4.2.1.- SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) GO:  fatty acid synthase complex    fatty-acid synthase activity    oxidoreductase activity    fatty acid biosynthesis    metabolism    CHAIN: C SWISS-PROT/TREMBL: P22414    KEYWORD: Fatty acid metabolism    Isomerase    Lyase    Multifunctional enzyme    NAD    Oxidoreductase    Peroxisome    Repeat    EC: 4.2.1.- SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) GO:  fatty acid synthase complex    fatty-acid synthase activity    oxidoreductase activity    fatty acid biosynthesis    metabolism    CHAIN: D SWISS-PROT/TREMBL: P22414    KEYWORD: Fatty acid metabolism    Isomerase    Lyase    Multifunctional enzyme    NAD    Oxidoreductase    Peroxisome    Repeat    EC: 4.2.1.- SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) SCOP: d.38.1.4 Alpha and beta proteins (a+b)    Thioesterase/thiol ester dehydrase-isomerase    Thioesterase/thiol ester dehydrase-isomerase    MaoC-like    2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase    Yeast (Candida tropicalis) GO:  fatty acid synthase complex    fatty-acid synthase activity    oxidoreductase activity    fatty acid biosynthesis    metabolism

Image Source: PDB

Loops in ArchDB40 clusters

1pn2_A_89 - HA => SUBCLASS : 2.3.2
1pn2_A_251 - HA => SUBCLASS : 4.1.2
1pn2_A_239 - HA => SUBCLASS : 4.35.1
1pn2_A_106 - HA => SUBCLASS : 5.8.2
1pn2_A_6 - EH => SUBCLASS : 0.1.3
1pn2_A_6 - EH => SUBCLASS : 0.1.55
1pn2_A_163 - EH => SUBCLASS : 1.1.35
1pn2_A_123 - AR => SUBCLASS : 1.2.1
1pn2_A_225 - AR => SUBCLASS : 8.11.1

Loops in ArchDB95 clusters

1pn2_A_6 - EH => SUBCLASS : 1.1.5
1pn2_A_123 - AR => SUBCLASS : 1.1.4
1pn2_A_225 - AR => SUBCLASS : 8.7.2
1pn2_A_89 - HA => SUBCLASS : 2.3.6
1pn2_A_251 - HA => SUBCLASS : 4.1.2
1pn2_A_239 - HA => SUBCLASS : 4.23.1
1pn2_A_239 - HA => SUBCLASS : 4.25.1
1pn2_A_106 - HA => SUBCLASS : 5.5.3

Loops not clustered in ArchDB

1pn2_A_63 - AR
1pn2_A_71 - AR
1pn2_A_137 - AR
1pn2_A_141 - EH
1pn2_A_208 - HE
1pn2_A_148 - HE
1pn2_A_53 - HE
1pn2_A_11 - HH
1pn2_A_28 - HH
1pn2_A_173 - HH
1pn2_A_190 - HH

1pn2 A - percentage of sequence identity: 100
1pn2 B - percentage of sequence identity: 100
1pn2 C - percentage of sequence identity: 100
1pn2 D - percentage of sequence identity: 100
1pn4 A - percentage of sequence identity: 99
1pn4 B - percentage of sequence identity: 99
1pn4 C - percentage of sequence identity: 99
1pn4 D - percentage of sequence identity: 99