PDB: 1r0w Compound: cystic fibrosis transmembrane conductance regulato Classification: TRANSPORT PROTEIN Entry date in PDB: 2003-12-09 Resolution [Å]: 2.20 R-Factor: 0.231

CHAIN: A SWISS-PROT/TREMBL: P26361    KEYWORD: Alternative splicing    ATP-binding    Chloride    Chloride channel    Glycoprotein    Ionic channel    Phosphorylation    Repeat    Transmembrane    Transport    SCOP: c.37.1.12 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    ABC transporter ATPase domain-like    Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain    Mouse (Mus musculus) GO:  integral to membrane    membrane    ATP binding    ATPase activity    ATPase activity, coupled to transmembrane movement of substances    chloride channel activity    nucleoside-triphosphatase activity    nucleotide binding    ion transport    transport    CHAIN: B SWISS-PROT/TREMBL: P26361    KEYWORD: Alternative splicing    ATP-binding    Chloride    Chloride channel    Glycoprotein    Ionic channel    Phosphorylation    Repeat    Transmembrane    Transport    SCOP: c.37.1.12 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    ABC transporter ATPase domain-like    Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain    Mouse (Mus musculus) GO:  integral to membrane    membrane    ATP binding    ATPase activity    ATPase activity, coupled to transmembrane movement of substances    chloride channel activity    nucleoside-triphosphatase activity    nucleotide binding    ion transport    transport    CHAIN: C SWISS-PROT/TREMBL: P26361    KEYWORD: Alternative splicing    ATP-binding    Chloride    Chloride channel    Glycoprotein    Ionic channel    Phosphorylation    Repeat    Transmembrane    Transport    Alternative splicing    ATP-binding    Chloride    Chloride channel    Glycoprotein    Ionic channel    Phosphorylation    Repeat    Transmembrane    Transport    SCOP: c.37.1.12 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    ABC transporter ATPase domain-like    Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain    Mouse (Mus musculus) GO:  integral to membrane    membrane    ATP binding    ATPase activity    ATPase activity, coupled to transmembrane movement of substances    chloride channel activity    nucleoside-triphosphatase activity    nucleotide binding    ion transport    transport    CHAIN: D SWISS-PROT/TREMBL: P26361    KEYWORD: Alternative splicing    ATP-binding    Chloride    Chloride channel    Glycoprotein    Ionic channel    Phosphorylation    Repeat    Transmembrane    Transport    SCOP: c.37.1.12 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    ABC transporter ATPase domain-like    Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain    Mouse (Mus musculus) GO:  integral to membrane    membrane    ATP binding    ATPase activity    ATPase activity, coupled to transmembrane movement of substances    chloride channel activity    nucleoside-triphosphatase activity    nucleotide binding    ion transport    transport

Image Source: PDB

Loops in ArchDB40 clusters

1r0w_A_430 - HE => SUBCLASS : 2.1.4
1r0w_A_607 - HE => SUBCLASS : 2.3.1
1r0w_A_430 - HE => SUBCLASS : 3.2.4
1r0w_A_607 - HE => SUBCLASS : 3.8.1
1r0w_A_615 - HA => SUBCLASS : 2.1.1
1r0w_A_599 - EH => SUBCLASS : 2.1.7
1r0w_A_623 - EH => SUBCLASS : 2.5.1
1r0w_A_439 - AR => SUBCLASS : 3.3.1
1r0w_A_439 - AR => SUBCLASS : 3.5.1
1r0w_A_630 - HH => SUBCLASS : 1.2.1
1r0w_A_514 - HH => SUBCLASS : 1.3.3

Loops in ArchDB95 clusters

1r0w_A_599 - EH => SUBCLASS : 2.1.12
1r0w_A_623 - EH => SUBCLASS : 2.5.1
1r0w_A_453 - EH => SUBCLASS : 6.1.1
1r0w_A_439 - AR => SUBCLASS : 2.3.1
1r0w_A_439 - AR => SUBCLASS : 2.3.2
1r0w_A_630 - HH => SUBCLASS : 1.2.1
1r0w_A_514 - HH => SUBCLASS : 1.3.2
1r0w_A_514 - HH => SUBCLASS : 1.3.4
1r0w_A_430 - HE => SUBCLASS : 2.1.8
1r0w_A_607 - HE => SUBCLASS : 2.2.1
1r0w_A_607 - HE => SUBCLASS : 2.2.5
1r0w_A_550 - HE => SUBCLASS : 4.29.1
1r0w_A_615 - HA => SUBCLASS : 2.1.1

Loops not clustered in ArchDB

1r0w_A_479 - AR
1r0w_A_488 - AR
1r0w_A_392 - EH
1r0w_A_500 - EH
1r0w_A_540 - EH
1r0w_A_568 - EH
1r0w_A_580 - HE
1r0w_A_527 - HE
1r0w_A_464 - HE
1r0w_A_405 - HH
1r0w_A_502 - HH
1r0w_A_638 - HH

1ckw A - percentage of sequence identity: 88
1ckx A - percentage of sequence identity: 92
1cky A - percentage of sequence identity: 92
1ckz A - percentage of sequence identity: 88
1q3h A - percentage of sequence identity: 100
1q3h B - percentage of sequence identity: 100
1q3h C - percentage of sequence identity: 100
1q3h D - percentage of sequence identity: 100
1r0w A - percentage of sequence identity: 100
1r0w B - percentage of sequence identity: 100
1r0w C - percentage of sequence identity: 100
1r0w D - percentage of sequence identity: 100
1r0x A - percentage of sequence identity: 100
1r0x B - percentage of sequence identity: 100
1r0x C - percentage of sequence identity: 100
1r0x D - percentage of sequence identity: 100
1r0y A - percentage of sequence identity: 100
1r0y B - percentage of sequence identity: 100
1r0y C - percentage of sequence identity: 100
1r0y D - percentage of sequence identity: 100
1r0z A - percentage of sequence identity: 100
1r0z B - percentage of sequence identity: 100
1r0z C - percentage of sequence identity: 100
1r0z D - percentage of sequence identity: 100
1r10 A - percentage of sequence identity: 100
1r10 B - percentage of sequence identity: 100
1xf9 A - percentage of sequence identity: 99
1xf9 B - percentage of sequence identity: 99
1xf9 C - percentage of sequence identity: 99
1xf9 D - percentage of sequence identity: 99
1xfa A - percentage of sequence identity: 99
1xfa B - percentage of sequence identity: 99
1xmi A - percentage of sequence identity: 79
1xmi B - percentage of sequence identity: 79
1xmi C - percentage of sequence identity: 79
1xmi D - percentage of sequence identity: 79
1xmi E - percentage of sequence identity: 79
1xmj A - percentage of sequence identity: 78
2bbo A - percentage of sequence identity: 79
2bbs A - percentage of sequence identity: 78
2bbs B - percentage of sequence identity: 78
2bbt A - percentage of sequence identity: 78
2bbt B - percentage of sequence identity: 78