PDB: 1rew Compound: bone morphogenetic protein 2 Classification: HORMONE/GROWTH FACTOR/SIGNALING PROTEIN Entry date in PDB: 2004-05-04 Resolution [Å]: 1.86 R-Factor: 0.209

CHAIN: A SWISS-PROT/TREMBL: P12643    KEYWORD: 3D-structure    Chondrogenesis    Cytokine    Glycoprotein    Growth factor    Osteogenesis    Signal    SCOP: g.17.1.2 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Transforming growth factor (TGF)-beta    Bone morphogenetic protein-2 (BMP-2)    Human (Homo sapiens) GO:  extracellular region    growth factor activity    growth    CHAIN: B SWISS-PROT/TREMBL: P12643    KEYWORD: 3D-structure    Chondrogenesis    Cytokine    Glycoprotein    Growth factor    Osteogenesis    Signal    SCOP: g.17.1.2 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Transforming growth factor (TGF)-beta    Bone morphogenetic protein-2 (BMP-2)    Human (Homo sapiens) GO:  extracellular region    growth factor activity    growth    CHAIN: C SWISS-PROT/TREMBL: P36894    KEYWORD: 3D-structure    ATP-binding    Disease mutation    Glycoprotein    Receptor    Serine/threonine-protein kinase    Signal    Transferase    Transmembrane    EC: 2.7.1.37 SCOP: g.7.1.3 Small proteins    Snake toxin-like    Snake toxin-like    Extracellular domain of cell surface receptors    BMP receptor Ia ectodomain    Human (Homo sapiens) GO:  membrane    ATP binding    protein kinase activity    protein serine/threonine kinase activity    protein-tyrosine kinase activity    receptor signaling protein serine/threonine kinase activity    transforming growth factor beta receptor activity    transmembrane receptor protein serine/threonine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein serine/threonine kinase signaling pathway    CHAIN: D SWISS-PROT/TREMBL: P36894    KEYWORD: 3D-structure    ATP-binding    Disease mutation    Glycoprotein    Receptor    Serine/threonine-protein kinase    Signal    Transferase    Transmembrane    EC: 2.7.1.37 SCOP: g.7.1.3 Small proteins    Snake toxin-like    Snake toxin-like    Extracellular domain of cell surface receptors    BMP receptor Ia ectodomain    Human (Homo sapiens) GO:  membrane    ATP binding    protein kinase activity    protein serine/threonine kinase activity    protein-tyrosine kinase activity    receptor signaling protein serine/threonine kinase activity    transforming growth factor beta receptor activity    transmembrane receptor protein serine/threonine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein serine/threonine kinase signaling pathway

Image Source: PDB

Loops in ArchDB40 clusters

1rew_C_58 - HA => SUBCLASS : 3.1.1
1rew_A_15 - AR => SUBCLASS : 1.4.1
1rew_A_37 - AR => SUBCLASS : 2.6.2
1rew_A_15 - AR => SUBCLASS : 3.26.1

Loops in ArchDB95 clusters

1rew_A_15 - AR => SUBCLASS : 1.4.2
1rew_C_58 - HA => SUBCLASS : 3.1.1
1rew_A_79 - HA => SUBCLASS : 5.4.6

Loops not clustered in ArchDB

1rew_C_52 - AR
1rew_A_32 - AR
1rew_C_71 - EH
1rew_A_20 - EH
1rew_A_42 - EH
1rew_C_36 - HA
1rew_C_83 - HE
1rew_A_23 - HE
1rew_A_59 - HE

1es7 B - percentage of sequence identity: 100
1es7 D - percentage of sequence identity: 100
1rew C - percentage of sequence identity: 100
1rew D - percentage of sequence identity: 100