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Information on 1www
PDB: 1www
Compound: nerve growth factor
Classification: NERVE GROWTH FACTOR/TRKA COMPLEX
Entry date in PDB: 1999-09-15
Resolution [Å]: 2.20
R-Factor: 0.189


CHAIN: V
SWISS-PROT/TREMBL: P01138
   KEYWORD: 3D-structure    Growth factor    Polymorphism    Signal   
SCOP: g.17.1.3 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Neurotrophin    beta-Nerve growth factor    Human (Homo sapiens)
GO:  growth factor activity   


CHAIN: W
SWISS-PROT/TREMBL: P01138
   KEYWORD: 3D-structure    Growth factor    Polymorphism    Signal   
SCOP: g.17.1.3 Small proteins    Cystine-knot cytokines    Cystine-knot cytokines    Neurotrophin    beta-Nerve growth factor    Human (Homo sapiens)
GO:  growth factor activity   


CHAIN: X
SWISS-PROT/TREMBL: P04629
   KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Chromosomal translocation    Disease mutation    Glycoprotein    Immunoglobulin domain    Leucine-rich repeat    Neurogenesis    Phosphorylation    Polymorphism    Proto-oncogene    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase   
EC: 2.7.1.112
SCOP: b.1.1.4 All beta proteins    Immunoglobulin-like beta-sandwich    Immunoglobulin    I set domains    NGF binding domain of trkA receptor    Human (Homo sapiens)
GO:  membrane    ATP binding    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway   


CHAIN: Y
SWISS-PROT/TREMBL: P04629
   KEYWORD: 3D-structure    Alternative splicing    ATP-binding    Chromosomal translocation    Disease mutation    Glycoprotein    Immunoglobulin domain    Leucine-rich repeat    Neurogenesis    Phosphorylation    Polymorphism    Proto-oncogene    Receptor    Repeat    Signal    Transferase    Transmembrane    Tyrosine-protein kinase   
EC: 2.7.1.112
SCOP: b.1.1.4 All beta proteins    Immunoglobulin-like beta-sandwich    Immunoglobulin    I set domains    NGF binding domain of trkA receptor    Human (Homo sapiens)
GO:  membrane    ATP binding    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway   
1www Image
Image Source: PDB

Stored Loops of 1www

Loops in ArchDB95 clusters

1www_V_35 - AR => SUBCLASS : 2.1.1
1www_V_17 - AR => SUBCLASS : 4.7.3
1www_X_342 - AR => SUBCLASS : 7.1.1
1www_X_342 - AR => SUBCLASS : 7.1.2
1www_V_27 - HA => SUBCLASS : 3.1.1
1www_X_328 - HA => SUBCLASS : 8.19.1

Loops not clustered in ArchDB

1www_X_284 - AR
1www_X_299 - AR
1www_V_53 - AR
1www_X_320 - AR
1www_V_48 - AR
1www_V_76 - HA
1www_V_41 - HA
1www_X_357 - HA
1www_X_312 - HA
1www_X_294 - HA
1www_V_6 - HE

Homologous structures to 1www classified in ArchDB

1b8k A - percentage of sequence identity: 60
1bet - - percentage of sequence identity: 92
1bnd B - percentage of sequence identity: 60
1btg A - percentage of sequence identity: 91
1btg B - percentage of sequence identity: 91
1btg C - percentage of sequence identity: 91
1he7 A - percentage of sequence identity: 100
1nt3 A - percentage of sequence identity: 60
1sg1 A - percentage of sequence identity: 100
1sg1 B - percentage of sequence identity: 100
1sgf B - percentage of sequence identity: 89
1sgf Y - percentage of sequence identity: 89
1www V - percentage of sequence identity: 100
1www W - percentage of sequence identity: 100