PDB: 2ak3 Compound: Adenylate kinase isoenzyme-3 (gtp Classification: TRANSFERASE (PHOSPHOTRANSFERASE) Entry date in PDB: 1995-05-08 Resolution [Å]: 1.85 R-Factor: 0.189

CHAIN: A SWISS-PROT/TREMBL: P08760    KEYWORD: 3D-structure    GTP-binding    Kinase    Mitochondrion    Transferase    EC: 2.7.4.10 SCOP: c.37.1.1 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    Nucleotide and nucleoside kinases    Adenylate kinase    Cow (Bos taurus), mitochondrial izozyme-3 SCOP: c.37.1.1 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    Nucleotide and nucleoside kinases    Adenylate kinase    Cow (Bos taurus), mitochondrial izozyme-3 SCOP: g.41.2.1 Small proteins    Rubredoxin-like    Microbial and mitochondrial ADK, insert "zinc finger" domain    Microbial and mitochondrial ADK, insert "zinc finger" domain    Microbial and mitochondrial ADK, insert "zinc finger" domain    Cow (Bos taurus), mitochondrial izozyme-3 GO:  adenylate kinase activity    ATP binding    nucleotide kinase activity    phosphotransferase activity, phosphate group as acceptor    nucleobase, nucleoside, nucleotide and nucleic acid metabolism    CHAIN: B SWISS-PROT/TREMBL: P08760    KEYWORD: 3D-structure    GTP-binding    Kinase    Mitochondrion    Transferase    EC: 2.7.4.10 SCOP: c.37.1.1 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    Nucleotide and nucleoside kinases    Adenylate kinase    Cow (Bos taurus), mitochondrial izozyme-3 SCOP: c.37.1.1 Alpha and beta proteins (a/b)    P-loop containing nucleoside triphosphate hydrolases    P-loop containing nucleoside triphosphate hydrolases    Nucleotide and nucleoside kinases    Adenylate kinase    Cow (Bos taurus), mitochondrial izozyme-3 SCOP: g.41.2.1 Small proteins    Rubredoxin-like    Microbial and mitochondrial ADK, insert "zinc finger" domain    Microbial and mitochondrial ADK, insert "zinc finger" domain    Microbial and mitochondrial ADK, insert "zinc finger" domain    Cow (Bos taurus), mitochondrial izozyme-3 GO:  adenylate kinase activity    ATP binding    nucleotide kinase activity    phosphotransferase activity, phosphate group as acceptor    nucleobase, nucleoside, nucleotide and nucleic acid metabolism

Image Source: PDB

Loops in ArchDB40 clusters

2ak3_A_126 - HA => SUBCLASS : 4.1.1
2ak3_A_108 - EH => SUBCLASS : 1.1.5
2ak3_A_191 - EH => SUBCLASS : 3.2.3
2ak3_A_7 - EH => SUBCLASS : 6.1.1
2ak3_A_36 - HH => SUBCLASS : 2.2.3
2ak3_A_49 - HH => SUBCLASS : 5.3.1

Loops in ArchDB95 clusters

2ak3_A_108 - EH => SUBCLASS : 1.1.3
2ak3_A_191 - EH => SUBCLASS : 3.5.2
2ak3_A_85 - EH => SUBCLASS : 5.51.1
2ak3_A_7 - EH => SUBCLASS : 6.1.1
2ak3_A_36 - HH => SUBCLASS : 2.2.4
2ak3_A_49 - HH => SUBCLASS : 5.4.1
2ak3_A_116 - HE => SUBCLASS : 0.1.36
2ak3_A_164 - HE => SUBCLASS : 2.4.5
2ak3_A_18 - HE => SUBCLASS : 2.6.4
2ak3_A_18 - HE => SUBCLASS : 2.6.7
2ak3_A_66 - HE => SUBCLASS : 2.6.14
2ak3_A_94 - HE => SUBCLASS : 4.8.2
2ak3_A_94 - HE => SUBCLASS : 4.47.1
2ak3_A_126 - HA => SUBCLASS : 4.1.1

Loops in ArchDB-EC clusters

2ak3_A_49 - HH => SUBCLASS : 5.3.2

Loops in ArchDB-KI clusters

2ak3_A_32 - EH => SUBCLASS : 0.1.1
2ak3_A_108 - EH => SUBCLASS : 1.1.1
2ak3_A_85 - EH => SUBCLASS : 5.1.1
2ak3_A_7 - EH => SUBCLASS : 6.1.1
2ak3_A_126 - HA => SUBCLASS : 4.1.1
2ak3_A_164 - HE => SUBCLASS : 2.4.2
2ak3_A_36 - HH => SUBCLASS : 2.2.1
2ak3_A_49 - HH => SUBCLASS : 5.1.1

Loops not clustered in ArchDB

2ak3_A_32 - EH
2ak3_A_134 - EH
2ak3_A_126 - HA

Loops not clustered in ArchDB-KI

2ak3_A_191 - EH
2ak3_A_134 - EH
2ak3_A_66 - HE
2ak3_A_94 - HE
2ak3_A_116 - HE
2ak3_A_18 - HE

1zd8 A - percentage of sequence identity: 92
2ak3 A - percentage of sequence identity: 100
2ak3 B - percentage of sequence identity: 100