PDB: 2fok Compound: foki restriction endonuclease Classification: NUCLEIC ACID RECOGNITION Entry date in PDB: 1998-06-17 Resolution [Å]: 2.30 R-Factor: 0.211

CHAIN: A SWISS-PROT/TREMBL: P14870    KEYWORD: 3D-structure    Endonuclease    Hydrolase    Magnesium    Nuclease    Restriction system    EC: 3.1.21.4 SCOP: a.4.5.12 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Flavobacterium okeanokoites SCOP: a.4.5.12 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Flavobacterium okeanokoites SCOP: a.4.5.12 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Flavobacterium okeanokoites SCOP: c.52.1.12 Alpha and beta proteins (a/b)    Restriction endonuclease-like    Restriction endonuclease-like    Restriction endonuclease FokI, C-terminal (catalytic) domain    Restriction endonuclease FokI, C-terminal (catalytic) domain    Flavobacterium okeanokoites GO:  type II site-specific deoxyribonuclease activity    DNA restriction-modification system    CHAIN: B SWISS-PROT/TREMBL: P14870    KEYWORD: 3D-structure    Endonuclease    Hydrolase    Magnesium    Nuclease    Restriction system    EC: 3.1.21.4 SCOP: a.4.5.12 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Flavobacterium okeanokoites SCOP: a.4.5.12 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Flavobacterium okeanokoites SCOP: a.4.5.12 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Restriction endonuclease FokI, N-terminal (recognition) domain    Flavobacterium okeanokoites SCOP: c.52.1.12 Alpha and beta proteins (a/b)    Restriction endonuclease-like    Restriction endonuclease-like    Restriction endonuclease FokI, C-terminal (catalytic) domain    Restriction endonuclease FokI, C-terminal (catalytic) domain    Flavobacterium okeanokoites GO:  type II site-specific deoxyribonuclease activity    DNA restriction-modification system

Image Source: PDB

Loops in ArchDB40 clusters

2fok_A_341 - HE => SUBCLASS : 1.1.3
2fok_A_528 - HE => SUBCLASS : 1.1.5
2fok_A_421 - HE => SUBCLASS : 2.2.1
2fok_A_341 - HE => SUBCLASS : 2.2.9
2fok_A_222 - HE => SUBCLASS : 2.4.1
2fok_A_104 - HE => SUBCLASS : 2.4.1
2fok_A_160 - HE => SUBCLASS : 3.2.8
2fok_A_160 - HE => SUBCLASS : 3.5.6
2fok_A_160 - HE => SUBCLASS : 3.17.1
2fok_A_358 - HA => SUBCLASS : 2.3.1
2fok_A_120 - HA => SUBCLASS : 4.19.1
2fok_A_146 - HH => SUBCLASS : 1.1.2
2fok_A_146 - HH => SUBCLASS : 1.1.3
2fok_A_146 - HH => SUBCLASS : 1.2.2
2fok_A_32 - HH => SUBCLASS : 1.7.2
2fok_A_197 - HH => SUBCLASS : 2.1.1
2fok_A_41 - HH => SUBCLASS : 3.5.2
2fok_A_41 - HH => SUBCLASS : 3.6.9
2fok_A_548 - HH => SUBCLASS : 4.1.1
2fok_A_548 - HH => SUBCLASS : 4.1.2
2fok_A_325 - HH => SUBCLASS : 5.7.1

Loops in ArchDB95 clusters

2fok_A_258 - AR => SUBCLASS : 2.4.2
2fok_A_146 - HH => SUBCLASS : 1.1.1
2fok_A_146 - HH => SUBCLASS : 1.1.4
2fok_A_32 - HH => SUBCLASS : 1.5.1
2fok_A_197 - HH => SUBCLASS : 2.1.12
2fok_A_548 - HH => SUBCLASS : 4.1.1
2fok_A_325 - HH => SUBCLASS : 5.1.1
2fok_A_528 - HE => SUBCLASS : 1.2.4
2fok_A_421 - HE => SUBCLASS : 2.1.1
2fok_A_341 - HE => SUBCLASS : 2.1.12
2fok_A_222 - HE => SUBCLASS : 2.4.1
2fok_A_104 - HE => SUBCLASS : 2.4.1
2fok_A_160 - HE => SUBCLASS : 3.2.6
2fok_A_358 - HA => SUBCLASS : 2.3.1
2fok_A_120 - HA => SUBCLASS : 4.18.1
2fok_A_120 - HA => SUBCLASS : 4.18.2

Loops in ArchDB-EC clusters

2fok_A_325 - HH => SUBCLASS : 5.8.1

Loops not clustered in ArchDB

2fok_A_240 - AR
2fok_A_240 - AR
2fok_A_258 - AR
2fok_A_66 - EH
2fok_A_542 - EH
2fok_A_515 - EH
2fok_A_463 - EH
2fok_A_364 - EH
2fok_A_128 - EH
2fok_A_175 - EH
2fok_A_264 - EH
2fok_A_323 - EH
2fok_A_358 - HA
2fok_A_245 - HA
2fok_A_120 - HA
2fok_A_451 - HA
2fok_A_439 - HA
2fok_A_245 - HA
2fok_A_439 - HA
2fok_A_451 - HA
2fok_A_49 - HE
2fok_A_303 - HE
2fok_A_479 - HE
2fok_A_565 - HE
2fok_A_269 - HH
2fok_A_17 - HH
2fok_A_68 - HH
2fok_A_87 - HH
2fok_A_177 - HH
2fok_A_209 - HH
2fok_A_411 - HH
2fok_A_389 - HH
2fok_A_133 - HH

1fok A - percentage of sequence identity: 99
2fok A - percentage of sequence identity: 100
2fok B - percentage of sequence identity: 100