ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 2.4.3

Subclass Accession number: 8242
Subclass: 2.4.3

Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates:

Consensus coordinates:

Number of loops: 26

Average sequence ID (%) : 13.0 +/- 17.2
Average RMSD (Å) : 0.700 +/- 0.155

Consensus geometry

d (Å): 11

delta (°): 90-135

theta (°): 135-180

rho (°): 135-180

Consensus Sequence:	XXhpXh
(φψ)-conformation:	aababb

Pattern:	[afgilmptv]	[degkqrs]	[adeknqrs]	[afgilmvy]	[adgkr]	[dehpqs]	x	[acgimtv]	[dgknst]	x	[fgilpvwy]	x	[cfilmtv]
Conservation:	-0.676	-0.070	-0.259	0.441	-1.079	0.828	-0.961	0.299	1.717	-1.196	0.414	-1.093	1.634

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1a4i_A_258	1a4i	A	258	268	YDEAKERASFI..	HHHHTTT-SEE..	aaaaaaaxabb..
1c4k_A_299	1c4k	A	303	315	VKRIGHLCDYIEF	HHHHGGGBSEEEE	aaaaaaababbbb
1cbg_*_156	1cbg	-	168	180	FKEFGDRVKHWIT	HHHHTTT--EEEE	aaaaaaaxabbba
1czf_A_35	1czf	A	38	50	AKAGKAKCSTITL	HHHHGGG-SEEEE	aaaaaaaxabbbx
1dqu_A_375	1dqu	A	382	393	AVAYAPFADLIW.	HHHHTTS-SEEE.	aaaaaaababbb.
1dqw_A_41	1dqw	A	48	60	VEALGPKICLLKT	HHHHGGG-SEEEE	aaaaaaababbxb
1dvj_A_24	1dvj	A	31	43	TGEVREYIDTVKI	HHHHGGG-SEEEE	aaaaaaababbbb
1e4m_M_159	1e4m	M	172	184	FEEFGDSVKYWLT	HHHHTTT--EEEE	aaaaaaaxabbba
1exn_A_134	1exn	A	137	149	VKLIGHLYDHVWL	HHHHGGGSS-EEE	aaaaaaababbbx
1f8m_A_265	1f8m	A	272	284	AKAYAPFADLIWM	HHHHGGG-SEEEE	aaaaaaababbbb
1geq_A_18	1geq	A	25	37	LLALDEYAGAIEL	HHHHGGGBS-EEE	aaaaaaaxabbbb
1gow_A_177	1gow	A	191	203	AWKFDDLVDEYST	HHHHTTT-SEEEE	aaaaaaaxabbba
1h49_A_163	1h49	A	176	188	FDNFGDKVKNWLT	HHHHTTT--EEEE	aaaaaaaxabbba
1hiz_A_123	1hiz	A	145	157	VERYKDDIKYWDV	HHHHTTT--EEEE	aaaaaaababbxa
1igw_B_269	1igw	B	276	288	GLAYAPYADLVWC	HHHHGGG-SEEEE	aaaaaaababbbb
1l1l_A_661	1l1l	A	665	677	LRQYRFITKSTSL	HHHTTTT-SEEEE	aaaaaaaxabbbb
1li4_A_262	1li4	A	262	274	MDEACQEGNIFVT	HHHHTTT-SEEEE	aaaaaaaxabbbb
1n8f_A_150	1n8f	A	150	162	PQYLADLMSWGAI	HHHHGGG-SEEEE	aaaaaaababbbb
1nhc_A_40	1nhc	A	43	55	ASESISSCSDVVL	HHHHGGG-SEEEE	aaaaaaababbbb
1o6z_A_109	1o6z	A	124	136	QSSLDEHNDDYIS	HHHHHTT-S--EE	aaaaaaababbxb
1od0_A_139	1od0	A	151	163	FENFGDRVKNWIT	HHHHTTT--EEEE	aaaaaaaxabbba
1q6o_A_15	1q6o	A	22	34	TRLIAEEVDIIEV	HHHHGGG-SEEEE	aaaaaaababbxx
1qox_A_138	1qox	A	151	163	FKELGGKIKQWIT	HHHHTTT--EEEE	aaaaaaababbba
1qw9_A_225	1qw9	A	231	243	LDHTYDHVDYISL	HHHHGGG-SEEEE	aaaaaaababbxb
1thf_D_184	1thf	D	187	199	IRFVRPLTTLPII	HHHHGGG--S-EE	aaaaaaabaxwbx
2nac_A_241	2nac	A	241	253	REDMYPVCDVVTL	HHHHGGG-SEEEE	aaaaaaababbbx

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1c4k_A_299	1c4k	A	PLPPYRIDOXAL-5'-PHOSPHATE	D - 316
1dvj_A_24	1dvj	A	UP66-AZA URIDINE 5'-MONOPHOSPHATE	K - 42
1e4m_M_159	1e4m	M	NAGN-ACETYL-D-GLUCOSAMINE	K - 165
1e4m_M_159	1e4m	M	NAGN-ACETYL-D-GLUCOSAMINE	D - 169
1e4m_M_159	1e4m	M	GOLGLYCEROL	K - 180
1exn_A_134	1exn	A	MSESELENOMETHIONINE	A - 134
1exn_A_134	1exn	A	MSESELENOMETHIONINE	Y - 135
1exn_A_134	1exn	A	MSESELENOMETHIONINE	I - 136
1exn_A_134	1exn	A	MSESELENOMETHIONINE	V - 137
1exn_A_134	1exn	A	MSESELENOMETHIONINE	H - 146
1exn_A_134	1exn	A	MSESELENOMETHIONINE	V - 147
1exn_A_134	1exn	A	MSESELENOMETHIONINE	W - 148
1exn_A_134	1exn	A	MSESELENOMETHIONINE	L - 149
1exn_A_134	1exn	A	MSESELENOMETHIONINE	I - 150
1f8m_A_265	1f8m	A	MGMAGNESIUM ION	W - 283
1f8m_A_265	1f8m	A	PYRPYRUVIC ACID	W - 283
1h49_A_163	1h49	A	BGCBETA-D-GLUCOSE	N - 190
1hiz_A_123	1hiz	A	GLCGLUCOSE	N - 159
1igw_B_269	1igw	B	HGMERCURY (II) ION	I - 269
1igw_B_269	1igw	B	HGMERCURY (II) ION	A - 272
1igw_B_269	1igw	B	MO3MAGNESIUM ION, 3 WATERS COORDINATED	W - 287
1igw_B_269	1igw	B	PYRPYRUVIC ACID	W - 287
1igw_B_269	1igw	B	HGMERCURY (II) ION	C - 288
1n8f_A_150	1n8f	A	PEPPHOSPHOENOLPYRUVATE	I - 162
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	A - 40
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	S - 41
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	E - 42
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	A - 43
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	S - 44
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	E - 45
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	S - 46
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	I - 47
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	S - 49
1nhc_A_40	1nhc	A	MANALPHA-D-MANNOSE	C - 50
1o6z_A_109	1o6z	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	I - 119
1o6z_A_109	1o6z	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	D - 122
1o6z_A_109	1o6z	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	I - 123
1o6z_A_109	1o6z	A	NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE	T - 138
1q6o_A_15	1q6o	A	MGMAGNESIUM ION	E - 33
1q6o_A_15	1q6o	A	LG6L-GULURONIC ACID 6-PHOSPHATE	E - 33
1q6o_A_15	1q6o	A	MGMAGNESIUM ION	V - 34
1qw9_A_225	1qw9	A	KHP2-HYDROXYMETHYL-5-(4-NITRO-PHENOXY)-TETRAHYDRO-FURAN-3,4-DIOL	H - 244
1qw9_A_225	1qw9	A	KHP2-HYDROXYMETHYL-5-(4-NITRO-PHENOXY)-TETRAHYDRO-FURAN-3,4-DIOL	Y - 246
1thf_D_184	1thf	D	PO4PHOSPHATE ION	S - 201

PDB Site Annotated loops in this subclass

Loop	PDB	Chain	Site	Residue
1hiz_A_123	1hiz	A	SO4SO4 BINDING SITE FOR RESIDUE A1383	R - 147

Clusters included in this Subclass