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Information on SUBCLASS 6.2.1
Subclass Accession number: 8638
Subclass: 6.2.1 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 46

Average sequence ID (%) : 16.7 +/- 16.8
Average RMSD (Å) : 0.685 +/- 0.284

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 135-180 rho (°): 90-135
Consensus Sequence: XXchXhpphX
(φψ)-conformation: aalbpaaabb
Pattern: x[ailmvy]xxxx[adegknqrs][acfikltv][dehknpqst]x[adegknqrst][adeknqrs][cilmtv]xx
Conservation:-1.2230.678-0.186-0.534-0.677-0.6461.1871.059-0.514-0.6060.3150.4042.125-1.382-1.000
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1auo_A_811auo   A96110EAQKRTGIDASRIFLHHHHHTT--GGGEEEaaaaaavxxaaabbb
1b8p_A_1601b8p   A169182QIAAKTGKPVSSIE.HHHHHHT--GGGEE.aaaaaavbxaaaxb.
1bd3_A_1711bd3   A178192EVLLRLGVKEERIIFHHHHHTT--GGGEEEaaaaaagxxaaabbx
1bdm_A_1561bdm   A165178QLAKKTGTGVDRIR.HHHHHHT--GGGEE.aaaaaavbxaaaxb.
1civ_A_1951civ   A204217QLALKAGVFYDKVS.HHHHHHTS-TTSEE.aaaaaavbxaaaxb.
1cqz_A_1631cqz   A168182FLLDTLKAKPNEVVFHHHHHHT--SSSEEEaaaaaavbxaaabbb
1dbf_A_171dbf   A3044KIIEENHTKPEDVVQHHHHHH---GGGEEEaaaaaavxxaaaxab
1dpt_A_701dpt   A8397FLTKELALGQDRILIHHHHHHT--GGGEEEaaaaaalbxaaabbb
1eok_A_2171eok   A226240YATGTNKIPASKMVFHHHHTS---GGGEEEaaaaaavxpaaaxbb
1ez4_A_1641ez4   A173186ALGKQFNVDPRSVD.HHHHHHT--GGGEE.aaaaaalbpaaabx.
1feh_A_3351feh   A335349YYPSISGLDPKNVFTHHHHTT---GGGEEEaaaaaavxxaaaxbb
1ffv_B_2391ffv   B245259VVSMLSGIPESKVRIHHHHHH---GGGEEEaaaaaavxpaaabbb
1ffv_B_5261ffv   B533547IIATELGIPSEVIQVHHHHHHT--GGGEEEaaaaaavbpaaaxxb
1ffv_B_5661ffv   B588602IAAHMLEVNENDLDWHHHHHTTS-GGGEEEaaaaaalbxaaabbx
1fg7_A_611fg7   A6680NYAQYAGVKPEQVLVHHHHHHTS-GGGEEEaaaaaavbxaaabbb
1g99_A_1811g99   A190204RAALMLGKPAEETKIHHHHHHTS-GGG-EEaaaaaavbxaaabbb
1gv1_A_1441gv1   A154167FIAMELGVSMQDIN.HHHHHH---GGGEE.aaaaaavbxaaabb.
1hye_A_1491hye   A158171AIAKFFGVHIDEVR.HHHHHHT--GGGEE.aaaaaavbxaaabb.
1iat_A_2491iat   A250264TKVKEFGIDPQNMFEHHHHHHT--GGGEEEaaaaaagxpaaabbx
1iqy_A_1161iqy   A120134KALAARNLDVSKVRVHHHHHTT--GGGEEEaaaaaavbxaaaxxb
1iv3_A_1091iv3   A115129SLSRLMRLPQDRIGLHHHHHHT--GGGEEEaaaaaalbxaaabbb
1k1e_A_841k1e   A90104DLMKQAGVTAEQTAYHHHHHHT--GGGEEEaaaaaavbxaaabbb
1kas_*_2771kas   -285299NALRDAGIEASQIGYHHHHHHT--GGGEEEaaaaaavbxaaaxab
1khh_A_1931khh   A194208PALLEAGFQRENICTHHHHHHT--GGGEEEaaaaaagxbaaaxbb
1ksi_A_1191ksi   A123137DSVKKRGLNLSEIVCHHHHHTT--GGGEEEaaaaaavxxaaabbb
1lc5_A_621lc5   A6781ALARHHQVPASWILAHHHHHHTS-GGGEEEaaaaaalbxaaabbx
1ldg_*_1651ldg   -175188YISQKLNVCPRDVN.HHHHHHTS-GGGEE.aaaaaalbpaaaxb.
1ldn_A_1641ldn   A173187LLGEYFSVAPQNVHAHHHHHHTS-GGGEEEaaaaaalbpaaaxbb
1lld_A_1511lld   A160173LIAQQTGVNVKNVH.HHHHHHT--GGGEE.aaaaaavbxaaabb.
1mfi_A_691mfi   A8296LLSDRLHISPDRVYIHHHHHH---GGGEEEaaaaaavxxaaabbb
1n62_B_2421n62   B248262VVSLISGLPEHKIHVHHHHHH---GGGEEEaaaaaavxxaaabbx
1n62_B_5321n62   B539553IIATELGIPADDIMIHHHHHHT--GGGEEEaaaaaavbwaaabbb
1n62_B_5761n62   B594608IAAHMLEVHEGDLEWHHHHHHTS-GGGEEEaaaaaalbxaaabbx
1nnl_A_1131nnl   A118132HVASKLNIPATNVFAHHHHHTT--GGGEEEaaaaaalxxaaabbb
1nq3_A_511nq3   A6478EILKAAGCDFTNVVKHHHHTTT--GGGEEEaaaaaavbbaaaxab
1o08_A_11491o08   A11531167AAAHAVGVAPSESIGHHHHHTT--GGGEEEaaaaaavbxaaabbb
1o6z_A_1651o6z   A175188VLSEEFDAPVQNVE.HHHHHHT--GGGEE.aaaaaalbxaaabb.
1ofg_A_671ofg   A7285IVAAEYGVDPRKIY.HHHHHHT--GGGEE.aaaaaavxxaaaxb.
1p3w_A_421p3w   A5771QIADLVGADPREIVFHHHHHHT--GGGEEEaaaaaavbxaaaxbx
1qlm_A_1471qlm   A152166HVADECGVDPENLYLHHHHHHTS-GGGEEEaaaaaavbxaaabbb
1qq5_A_1501qq5   A155169LVEEVLGVTPAEVLFHHHHHH---GGGEEEaaaaaavbxaaabbx
1ur5_A_1451ur5   A155169FIAMEAGVSVEDVQAHHHHHHT--GGGEEEaaaaaavbxaaabbb
1zrn_*_1541zrn   -159173LAEQALGLDRSAILFHHHHHHTS-GGGEEEaaaaaavbxaaabxx
5mdh_A_1565mdh   A165178QIALKLGVTSDDVK.HHHHHHT--GGGEE.aaaaaavbxaaaxb.
7mdh_A_1997mdh   A208221QLALKAGVFYDKVS.HHHHHTTS-GGGEE.aaaaaalbxaaabb.
9ldt_A_1669ldt   A175188LMGERLGVHPLSCH.HHHHHHTS-GGGEE.aaaaaavbpaaabb.
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1bd3_A_1711bd3   A     PO4PHOSPHATE ION G - 171
1bd3_A_1711bd3   A     PO4PHOSPHATE ION S - 172
1bd3_A_1711bd3   A     PO4PHOSPHATE ION V - 173
1bdm_A_1561bdm   A     NAXBETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE R - 156
1bdm_A_1561bdm   A     NAXBETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE L - 157
1bdm_A_1561bdm   A     NAXBETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE D - 158
1civ_A_1951civ   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 196
1civ_A_1951civ   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE D - 197
1dbf_A_171dbf   A     GOLGLYCEROL L - 21
1dbf_A_171dbf   A     GOLGLYCEROL K - 25
1ez4_A_1641ez4   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE S - 164
1ez4_A_1641ez4   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 165
1ez4_A_1641ez4   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE R - 169
1feh_A_3351feh   A     HC12 IRON/2 SULFUR/5 CARBONYL/2 WATER INORGANIC CLUSTER V - 352
1feh_A_3351feh   A     HC12 IRON/2 SULFUR/5 CARBONYL/2 WATER INORGANIC CLUSTER M - 353
1ffv_B_5261ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) H - 526
1ffv_B_5261ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) T - 529
1ffv_B_5261ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) Y - 530
1ffv_B_5261ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) I - 533
1ffv_B_5661ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) S - 566
1ffv_B_5661ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) T - 567
1ffv_B_5661ffv   B     PCD(MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V) P - 568
1fg7_A_611fg7   A     MSESELENOMETHIONINE Y - 70
1fg7_A_611fg7   A     MSESELENOMETHIONINE L - 79
1fg7_A_611fg7   A     MSESELENOMETHIONINE V - 80
1g99_A_1811g99   A     ADPADENOSINE-5'-DIPHOSPHATE H - 208
1g99_A_1811g99   A     ADPADENOSINE-5'-DIPHOSPHATE L - 209
1hye_A_1491hye   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 150
1iv3_A_1091iv3   A     MGMAGNESIUM ION K - 132
1k1e_A_841k1e   A     COCOBALT (II) ION K - 84
1k1e_A_841k1e   A     HGMERCURY (II) ION K - 84
1k1e_A_841k1e   A     HGMERCURY (II) ION C - 88
1k1e_A_841k1e   A     HGMERCURY (II) ION F - 89
1k1e_A_841k1e   A     GOLGLYCEROL F - 89
1k1e_A_841k1e   A     GOLGLYCEROL D - 90
1k1e_A_841k1e   A     GOLGLYCEROL L - 91
1k1e_A_841k1e   A     HGMERCURY (II) ION M - 92
1k1e_A_841k1e   A     GOLGLYCEROL M - 92
1k1e_A_841k1e   A     GOLGLYCEROL K - 93
1k1e_A_841k1e   A     GOLGLYCEROL Q - 94
1k1e_A_841k1e   A     HGMERCURY (II) ION T - 102
1k1e_A_841k1e   A     HGMERCURY (II) ION A - 103
1k1e_A_841k1e   A     HGMERCURY (II) ION Y - 104
1k1e_A_841k1e   A     COCOBALT (II) ION G - 106
1ksi_A_1191ksi   A     NAGN-ACETYL-D-GLUCOSAMINE N - 131
1ksi_A_1191ksi   A     NAGN-ACETYL-D-GLUCOSAMINE L - 132
1ksi_A_1191ksi   A     NAGN-ACETYL-D-GLUCOSAMINE S - 133
1ksi_A_1191ksi   A     NAGN-ACETYL-D-GLUCOSAMINE E - 134
1ldg_*_1651ldg   *     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 167
1ldg_*_1651ldg   *     OXMOXAMIC ACID L - 167
1ldg_*_1651ldg   *     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE D - 168
1ldg_*_1651ldg   *     OXMOXAMIC ACID D - 168
1ldg_*_1651ldg   *     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE R - 171
1ldg_*_1651ldg   *     OXMOXAMIC ACID R - 171
1ldn_A_1641ldn   A     OXMOXAMIC ACID L - 165
1ldn_A_1641ldn   A     OXMOXAMIC ACID D - 166
1ldn_A_1641ldn   A     OXMOXAMIC ACID R - 169
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE R - 171
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE P - 182
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE Q - 183
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE N - 184
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE V - 185
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE H - 186
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE A - 187
1ldn_A_1641ldn   A     FBPFRUCTOSE-1,6-DIPHOSPHATE Y - 188
1lld_A_1511lld   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 152
1mfi_A_691mfi   A     FHC2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE Y - 95
1mfi_A_691mfi   A     FHC2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE I - 96
1mfi_A_691mfi   A     FHC2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE N - 97
1mfi_A_691mfi   A     FHC2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE Y - 99
1n62_B_5321n62   B     MCNPTERIN CYTOSINE DINUCLEOTIDE H - 532
1n62_B_5321n62   B     MCNPTERIN CYTOSINE DINUCLEOTIDE T - 535
1n62_B_5321n62   B     MCNPTERIN CYTOSINE DINUCLEOTIDE Y - 536
1n62_B_5321n62   B     MCNPTERIN CYTOSINE DINUCLEOTIDE I - 539
1o08_A_11491o08   A     G16ALPHA-D-GLUCOSE 1,6-BISPHOSPHATE E - 1169
1o08_A_11491o08   A     MGMAGNESIUM ION E - 1169
1o6z_A_1651o6z   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE G - 165
1ofg_A_671ofg   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE K - 69
1qlm_A_1471qlm   A     PO4PHOSPHATE ION H - 152
1qlm_A_1471qlm   A     PO4PHOSPHATE ION E - 156
1ur5_A_1451ur5   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 147
1ur5_A_1451ur5   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE D - 148
1ur5_A_1451ur5   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE R - 151
1ur5_A_1451ur5   A     CDCADMIUM ION E - 165
5mdh_A_1565mdh   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 157
5mdh_A_1565mdh   A     MAKALPHA-KETOMALONIC ACID L - 157
5mdh_A_1565mdh   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE D - 158
5mdh_A_1565mdh   A     MAKALPHA-KETOMALONIC ACID D - 158
5mdh_A_1565mdh   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE R - 161
5mdh_A_1565mdh   A     MAKALPHA-KETOMALONIC ACID R - 161
7mdh_A_1997mdh   A     ZNZINC ION L - 200
7mdh_A_1997mdh   A     ZNZINC ION D - 201
7mdh_A_1997mdh   A     ZNZINC ION R - 204
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1o6z_A_1651o6z   A AC2CL BINDING SITE FOR CHAIN AR - 166
1ur5_A_1451ur5   A AC8CD BINDING SITE FOR CHAIN CE - 159
1ur5_A_1451ur5   A AC5CD BINDING SITE FOR CHAIN AE - 165

Clusters included in this Subclass
CLUSTER: HE.5.8
CLUSTER: HE.6.1
CLUSTER: HE.7.0