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Information on SUBCLASS 6.2.1
Subclass Accession number: 2486
Subclass: 6.2.1 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>50 %)  3.4 (>75 %)  3.4.11 (>75 %)  3.4.25 (>75 %)  3.4.25.1 (>75 %)  
GO : GO:0004177 (>75 %)  GO:0008233 (>75 %)  GO:0008235 (>75 %)  GO:0008237 (>75 %)  GO:0008238 (>75 %)  
SCOP : 47112 (>50 %)  47113 (>50 %)  55919 (>75 %)  55920 (>75 %)  55921 (>75 %)  56234 (>75 %)  56235 (>75 %)  56251 (>75 %)  
 Number of loops: 12

Average sequence ID (%) : 18.2 +/- 16.8
Average RMSD (Å) : 0.533 +/- 0.161

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 90-135 rho (°): 315-360
Consensus Sequence: pXcppphXXp
(φψ)-conformation: aalbabpbaa
Pattern: xx[fgilmy][agiltv]x[denrst][ILV][AILTV][deknqrsty][aders][ASV]xx[aflmy][ACLMT][aeknqrt][dhqr][aegnr][GKNR][AKRS][DKQRST][akrt][ILV][adegknqst][aglmptv][deknr][deh][FILV]x[fklm][astv]
Conservation:-1.116-1.049-0.819-0.607-0.735-0.3082.1290.505-0.735-0.3261.938-1.104-1.200-0.4990.450-0.220-0.271-0.5480.8390.9860.360-0.0982.182-0.639-1.120-0.2771.1981.630-0.728-0.2990.480
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1b67_A_231b67   A3464EEMGEEIASEAVKLAKHAGRKTIKAEDIELAHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaavbaxxbaaaaaaa
1fnn_A_2391fnn   A239269ARLAIDILYRSAYAAQQNGRKHIAPEDVRKSHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaavxabxbaaaaaaa
1g8p_A_2881g8p   A288318LRGELTLLRSARALAALEGATAVGRDHLKRVHHHHHHHHHHHHHHHHHTT-SB--HHHHHHHaaaaaaaaaaaaaaaaaavxabxbaaaaaaa
1h3o_B_851h3o   B89119DDFIESVVTAACQLARHRKSSTLEVKDVQLHHHHHHHHHHHHHHHHHHTT--S--HHHHHHHaaaaaaaaaaaaaaaaaavbNbxbaaaaaaa
1in4_A_2161in4   A216246PRIAIRLTKRVRDMLTVVKADRINTDIVLKTHHHHHHHHHHHHHHHHHHT-SSB-HHHHHHHaaaaaaaaggaaaaaaaalbabxbaaaaaaa
1lv7_A_3611lv7   A361391GADLANLVNEAALFAARGNKRVVSMVEFEKAHHHHHHHHHHHHHHHHHTT-SSB-HHHHHHHaaaaaaaaaaaaaaaaaalbabxbaaaaaaa
1n1j_A_781n1j   A89119SEFISFITSEASERCHQEKRKTINGEDILFAHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaavbabxbaaaaaaa
1n1j_B_641n1j   B74104QIFITELTLRAWIHTEDNKRRTLQRNDIAMAHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaalbabxbaaaaaaa
1s32_B_501s32   B5989KVFLENVIRDAVTYTEHAKRKTVTAMDVVYAHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaalbabxxaaaaaaa
1s32_C_8461s32   C856886EYLTAEILELAGNAARDNKKTRIIPRHLQLAHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaalbabxbaaaaaaa
1taf_A_401taf   A5080FRYVTSILDDAKVYANHARKKTIDLDDVRLAHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaavbabxbaaaaaaa
1taf_B_261taf   B3767SIKLKRIVQDAAKFMNHAKRQKLSVRDIDMSHHHHHHHHHHHHHHHHHTT-SS--HHHHHHHaaaaaaaaaaaaaaaaaavbabxbaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1fnn_A_2391fnn   A     ADPADENOSINE-5'-DIPHOSPHATE A - 239
1fnn_A_2391fnn   A     ADPADENOSINE-5'-DIPHOSPHATE R - 240
1fnn_A_2391fnn   A     ADPADENOSINE-5'-DIPHOSPHATE I - 243
1h3o_B_851h3o   B     MSESELENOMETHIONINE L - 85
1h3o_B_851h3o   B     MSESELENOMETHIONINE Q - 86
1h3o_B_851h3o   B     MSESELENOMETHIONINE I - 87
1h3o_B_851h3o   B     MSESELENOMETHIONINE A - 88
1h3o_B_851h3o   B     MSESELENOMETHIONINE F - 91
1h3o_B_851h3o   B     MSESELENOMETHIONINE Q - 117
1h3o_B_851h3o   B     MSESELENOMETHIONINE L - 120
1h3o_B_851h3o   B     MSESELENOMETHIONINE E - 121
1h3o_B_851h3o   B     MSESELENOMETHIONINE R - 122
1h3o_B_851h3o   B     MSESELENOMETHIONINE Q - 123
1in4_A_2161in4   A     ADPADENOSINE-5'-DIPHOSPHATE P - 216
1in4_A_2161in4   A     ADPADENOSINE-5'-DIPHOSPHATE R - 217
1in4_A_2161in4   A     ADPADENOSINE-5'-DIPHOSPHATE I - 220
1taf_B_261taf   B     ZNZINC ION D - 27
1taf_B_261taf   B     ZNZINC ION A - 28
1taf_B_261taf   B     ZNZINC ION E - 31
1taf_B_261taf   B     ZNZINC ION L - 32
1taf_B_261taf   B     ZNZINC ION D - 35
1taf_B_261taf   B     ZNZINC ION Q - 45
1taf_B_261taf   B     ZNZINC ION A - 48
1taf_B_261taf   B     ZNZINC ION K - 49
1taf_B_261taf   B     ZNZINC ION S - 60
1taf_B_261taf   B     ZNZINC ION V - 61
1taf_B_261taf   B     ZNZINC ION R - 62
1taf_A_401taf   A     ZNZINC ION A - 67
1taf_A_401taf   A     ZNZINC ION K - 69
1taf_A_401taf   A     ZNZINC ION D - 73
1taf_A_401taf   A     ZNZINC ION L - 74
1taf_A_401taf   A     ZNZINC ION D - 75
1taf_A_401taf   A     ZNZINC ION D - 76
1taf_A_401taf   A     ZNZINC ION V - 77
1taf_A_401taf   A     ZNZINC ION R - 78
1taf_A_401taf   A     ZNZINC ION L - 79
1taf_A_401taf   A     ZNZINC ION T - 81
1taf_A_401taf   A     ZNZINC ION E - 82

Clusters included in this Subclass
CLUSTER: HH.6.11