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Information on SUBCLASS 2.1.1
Subclass Accession number: 156
Subclass: 2.1.1
Type: HH alpha-alpha
DB: ArchDB-KI
 Number of loops: 6

Average sequence ID (%) : 75.9 +/- 3.4
Average RMSD (Å) : 0.33 +/- 0.15

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 90-135 rho (°): 0-45
Consensus Sequence: IEIPAE
(φψ)-conformation: aabpaa
Pattern: [R][G][D][L][G][IV][E][I][P][AV]{E}[EK][V][FIL][AFL][AV][Q][K][KM][ILM][I]{AG}[KR][CS]{N}{R}
Conservation:0.8471.4291.4290.2641.429-0.0160.8470.2642.012-0.857-0.651-0.2830.264-0.900-1.546-0.8740.8470.847-0.860-0.5530.264-1.478-0.000-0.192-1.283-1.250
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a3w_A_2641a3w   A264289RGDLGIEIPAPEVLAVQKKLIAKSNLHHHHHHHTTGGGHHHHHHHHHHHHHHaaaaaaabpaaaaaaaaaaaaaaaaa
1a49_A_2931a49   A293318RGDLGIEIPAEKVFLAQKMIIGRCNRHHHHHHHS-GGGHHHHHHHHHHHHHHaaaaaaabxaaaaaaaaaaaaaaaaa
1aqf_A_2931aqf   A293318RGDLGIEIPAEKVFLAQKMIIGRCNRHHHHHHHS-GGGHHHHHHHHHHHHHHaaaaaaabxaaaaaaaaaaaaaaaaa
1pkm_*_2931pkm   -293318RGDLGIEIPAEKVFLAQKMMIGRCNRHHHHHHHS-TTTHHHHHHHHHHHHHHaaaaaaabpaaaaaaaaaaaaaaaaa
1pkn_*_2931pkn   -293318RGDLGIEIPAEKVFLAQKMIIGRCNRHHHHHHHS-GGGHHHHHHHHHHHHHHaaaaaaabxaaaaaaaaaaaaaaaaa
1pky_A_2441pky   A244269RGDLGVEIPVEEVIFAQKMMIEKCIRHHHHHHHS-GGGHHHHHHHHHHHHHHaaaaaaabpaaaaaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1a3w_A_2641a3w   A     PGA2-PHOSPHOGLYCOLIC ACID R - 264
1a3w_A_2641a3w   A     MNMANGANESE (II) ION G - 265
1a3w_A_2641a3w   A     PGA2-PHOSPHOGLYCOLIC ACID G - 265
1a3w_A_2641a3w   A     MNMANGANESE (II) ION D - 266
1a3w_A_2641a3w   A     PGA2-PHOSPHOGLYCOLIC ACID D - 266
1a3w_A_2641a3w   A     MNMANGANESE (II) ION L - 267
1a3w_A_2641a3w   A     PGA2-PHOSPHOGLYCOLIC ACID L - 267
1a49_A_2931a49   A     OXLOXALATE ION R - 293
1a49_A_2931a49   A     OXLOXALATE ION G - 294
1a49_A_2931a49   A     MGMAGNESIUM ION G - 294
1a49_A_2931a49   A     OXLOXALATE ION D - 295
1a49_A_2931a49   A     MGMAGNESIUM ION D - 295
1a49_A_2931a49   A     ATPADENOSINE-5'-TRIPHOSPHATE D - 295
1a49_A_2931a49   A     OXLOXALATE ION L - 296
1a49_A_2931a49   A     MGMAGNESIUM ION L - 296
1aqf_A_2931aqf   A     PEQL-PHOSPHOLACTATE R - 293
1aqf_A_2931aqf   A     PEQL-PHOSPHOLACTATE G - 294
1aqf_A_2931aqf   A     MGMAGNESIUM ION G - 294
1aqf_A_2931aqf   A     PEQL-PHOSPHOLACTATE D - 295
1aqf_A_2931aqf   A     MGMAGNESIUM ION D - 295
1aqf_A_2931aqf   A     PEQL-PHOSPHOLACTATE L - 296
1pkn_*_2931pkn   *     PYRPYRUVIC ACID R - 293
1pkn_*_2931pkn   *     PYRPYRUVIC ACID G - 294
1pkn_*_2931pkn   *     MNMANGANESE (II) ION G - 294
1pkn_*_2931pkn   *     PYRPYRUVIC ACID D - 295
1pkn_*_2931pkn   *     MNMANGANESE (II) ION D - 295
1pkn_*_2931pkn   *     PYRPYRUVIC ACID L - 296
Bibliographic annotations
LoopPDBChainAnnotationResidue
1a3w_A_2641a3w   RefM.S.JURICA,A.MESECAR,P.J.HEATH,W.SHI,T.NOWAK,B.L.STODDARD. THE ALLOSTERIC REGULATION OF PYRUVATE KINASE BY FRUCTOSE-1,6-BISPHOSPHATE  STRUCTURE (LONDON) v.6;195,1998AMn ION BINDING RESIDUED - 266
1a3w_A_2641a3w   RefM.S.JURICA,A.MESECAR,P.J.HEATH,W.SHI,T.NOWAK,B.L.STODDARD. THE ALLOSTERIC REGULATION OF PYRUVATE KINASE BY FRUCTOSE-1,6-BISPHOSPHATE  STRUCTURE (LONDON) v.6;195,1998AMn ION BINDING RESIDUED - 266
1a49_A_2931a49   RefT.M.LARSEN,M.M.BENNING,I.RAYMENT,G.H.REED. STRUCTURE OF THE BIS(MG2+)-ATP-OXALATE COMPLEX OF THE RABBIT MUSCLE PYRUVATE KINASE AT 2.1 A RESOLUTION: ATP BINDING OVER A BARREL  BIOCHEMISTRY v.37;6247,1998AMg ION BINDING RESIDUE (ATP)D - 295
1a49_A_2931a49   RefT.M.LARSEN,M.M.BENNING,I.RAYMENT,G.H.REED. STRUCTURE OF THE BIS(MG2+)-ATP-OXALATE COMPLEX OF THE RABBIT MUSCLE PYRUVATE KINASE AT 2.1 A RESOLUTION: ATP BINDING OVER A BARREL  BIOCHEMISTRY v.37;6247,1998AMg ION BINDING RESIDUE (ATP)D - 295
1a49_A_2931a49   RefT.M.LARSEN,M.M.BENNING,I.RAYMENT,G.H.REED. STRUCTURE OF THE BIS(MG2+)-ATP-OXALATE COMPLEX OF THE RABBIT MUSCLE PYRUVATE KINASE AT 2.1 A RESOLUTION: ATP BINDING OVER A BARREL  BIOCHEMISTRY v.37;6247,1998AP-ATP BINDING RESIDUED - 295
1aqf_A_2931aqf   RefT.M.LARSEN,M.M.BENNING,G.E.WESENBERG,I.RAYMENT,G.H.REED. LIGAND-INDUCED DOMAIN MOVEMENT IN PYRUVATE KINASE: STRUCTURE OF THE ENZYME FROM RABBIT MUSCLE WITH MG2+, K+, AND L-PHOSPHOLACTATE AT 2.7 A RESOLUTION  ARCH.BIOCHEM.BIOPHYS. v.345;199,1997AMg ION BINDING RESIDUED - 295
1aqf_A_2931aqf   RefT.M.LARSEN,M.M.BENNING,G.E.WESENBERG,I.RAYMENT,G.H.REED. LIGAND-INDUCED DOMAIN MOVEMENT IN PYRUVATE KINASE: STRUCTURE OF THE ENZYME FROM RABBIT MUSCLE WITH MG2+, K+, AND L-PHOSPHOLACTATE AT 2.7 A RESOLUTION  ARCH.BIOCHEM.BIOPHYS. v.345;199,1997AMg ION BINDING RESIDUED - 295

Clusters included in this Subclass
CLUSTER: HH.4.5