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Information on SUBCLASS 5.1.1
Subclass Accession number: 176
Subclass: 5.1.1
Type: HH alpha-alpha
DB: ArchDB-KI
 Number of loops: 14

Average sequence ID (%) : 32.6 +/- 4.6
Average RMSD (Å) : 0.67 +/- 0.55

Consensus geometry
d (Å): 15 delta (°): 90-135 theta (°): 90-135 rho (°): 135-180
Consensus Sequence: pXGphVXpp
(φψ)-conformation: aalppppaa
Pattern: {DEKNQT}{CFIMY}[IM]{DEK}{DEKNQR}{G}{DEKQ}[ILP][IV]{PST}{DQS}{DEY}{ILTV}x{ILMV}x[AILM][ILV]{EKR}{DEHKN}x
Conservation:-0.919-1.2121.287-0.022-0.5851.967-0.0480.2092.1720.082-0.886-0.3090.201-0.5350.373-1.4510.5331.269-0.489-0.570-1.067
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1ak2_*_601ak2   -6787ATMDAGKLVSDEMVLELIEKNHHHHTT----HHHHHHHHHHHaaaaavxxxxaaaaaaaaaaa
1ake_A_501ake   A5171DIMDAGKLVTDELVIALVKERHHHHHT----HHHHHHHHHHHaaaaavbxxxaaaaaaaaaaa
1aky_*_481aky   -5575KIMDQGGLVSDDIMVNMIKDEHHHHTT----HHHHHHHHHHHaaaaavxbxpaaaaaaaaaaa
1ank_A_501ank   A5171DIMDAGKLVTDELVIALVKERHHHHHT----HHHHHHHHHHHaaaaavxxxxaaaaaaaaaaa
1kob_A_2191kob   A219239PEIVDREPVGFYTDMWAIGVLHHHHTT--B-HHHHHHHHHHHaaaaalbxbbaaaaaaaaaaa
1qf9_A_521qf9   A5777TMIKNGEIVPSIVTVKLLKNAHHHHTT----HHHHHHHHHHHaaaaavxxxpaaaaaaaaaaa
1uke_*_541uke   -5777TMIKNGEIVPSIVTVKLLKNAHHHHHT----HHHHHHHHHHHaaaaavxbppaaaaaaaaaaa
1uky_*_631uky   -6888NCIKEGQIVPQEITLALLRNAHHHHTT----HHHHHHHHHHHaaaaavxxppaaaaaaaaaaa
1ukz_*_631ukz   -6888NCIKEGQIVPQEITLALLRNAHHHHTT----HHHHHHHHHHHaaaaavxxxpaaaaaaaaaaa
1zak_A_491zak   A5676EFMEKGQLVPDEIVVNMVKERHHHHTT----HHHHHHHHHHHaaaaavxxxpaaaaaaaaaaa
1zip_*_441zip   -5171QYMDRGDLVPDEVTIGIVRERHHHHHT----HHHHHHHHHHHaaaaavxxxpaaaaaaaaaaa
2ak3_A_492ak3   A5676TFIDQGKLIPDDVMTRLVLHEHHHHTT----HHHHHHHHHHHaaaaalbxx-aaaaaaaaaaa
2eck_A_502eck   A5171DIMDAGKLVTDELVIALVKERHHHTTT----HHHHHHHHHHHaaaaagxxxpaaaaaaaaaaa
3adk_*_523adk   -5979EIMEKGQLVPLETVLDMLRDAHHHTTT----HHHHHHHHHHHaaaaavxxxxaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE I - 52
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE M - 53
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 56
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE K - 57
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE L - 58
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE V - 59
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE T - 60
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 61
1ake_A_501ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE V - 64
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE A - 53
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE I - 56
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE M - 57
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 58
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 60
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 61
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE L - 62
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE V - 63
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE S - 64
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 65
1aky_*_481aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE M - 68
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE I - 52
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE M - 53
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE G - 56
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE K - 57
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE L - 58
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE V - 59
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE T - 60
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE D - 61
1ank_A_501ank   A     AMPADENOSINE MONOPHOSPHATE V - 64
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE I - 55
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE M - 58
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE I - 59
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE K - 60
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE N - 61
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE G - 62
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE E - 63
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE I - 64
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE V - 65
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE P - 66
1qf9_A_521qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE T - 70
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE I - 55
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE M - 58
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE I - 59
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE K - 60
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE N - 61
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE G - 62
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE E - 63
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE I - 64
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE V - 65
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE P - 66
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE T - 70
1uke_*_541uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE L - 74
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE I - 66
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE C - 69
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE I - 70
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE K - 71
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE G - 73
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE Q - 74
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE I - 75
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE V - 76
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE P - 77
1uky_*_631uky   *     ADPADENOSINE-5'-DIPHOSPHATE T - 81
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE I - 66
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE C - 69
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE I - 70
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE K - 71
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE E - 72
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE G - 73
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE Q - 74
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE I - 75
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE V - 76
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE P - 77
1ukz_*_631ukz   *     AMPADENOSINE MONOPHOSPHATE T - 81
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE F - 57
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE M - 58
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 61
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Q - 62
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE L - 63
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE V - 64
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE P - 65
1zak_A_491zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE V - 69
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE A - 49
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Y - 52
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE M - 53
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 54
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 56
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 57
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE L - 58
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE V - 59
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE P - 60
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 61
1zip_*_441zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE T - 64
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE F - 57
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE I - 58
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE G - 61
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE K - 62
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE L - 63
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE I - 64
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE P - 65
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE D - 66
2ak3_A_492ak3   A     AMPADENOSINE MONOPHOSPHATE M - 69
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE I - 52
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE M - 53
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE D - 54
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE A - 55
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE G - 56
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE K - 57
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE L - 58
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE V - 59
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE T - 60
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE D - 61
2eck_A_502eck   A     AMPADENOSINE MONOPHOSPHATE V - 64
Bibliographic annotations
LoopPDBChainAnnotationResidue
1ake_A_501ake   RefC.W.MUELLER,G.E.SCHULZ. STRUCTURE OF THE COMPLEX BETWEEN ADENYLATE KINASE FROM ESCHERICHIA COLI AND THE INHIBITOR AP=5=A REFINED AT 1.9 ANGSTROMS RESOLUTION: A MODEL FOR A CATALYTIC TRANSITION STATE  J.MOL.BIOL. v.224;159,1992AAMP BINDING RESIDUE D - 61
1ake_A_501ake   RefC.W.MUELLER,G.E.SCHULZ. STRUCTURE OF THE COMPLEX BETWEEN ADENYLATE KINASE FROM ESCHERICHIA COLI AND THE INHIBITOR AP=5=A REFINED AT 1.9 ANGSTROMS RESOLUTION: A MODEL FOR A CATALYTIC TRANSITION STATE  J.MOL.BIOL. v.224;159,1992AAMP BINDING RESIDUE D - 61
1ank_A_501ank   RefM.B.BERRY,B.MEADOR,T.BILDERBACK,P.LIANG,M.GLASER,G.N.PHILLIPS JUNIOR. THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP  PROTEINS v.19;183,1994AAMP BINDING RESIDUE K - 57
1ank_A_501ank   RefM.B.BERRY,B.MEADOR,T.BILDERBACK,P.LIANG,M.GLASER,G.N.PHILLIPS JUNIOR. THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP  PROTEINS v.19;183,1994AAMP BINDING RESIDUE V - 59
2eck_A_502eck   RefM.B.BERRY,T.BILDERBACK,M.GLASER,G.N.PHILLIPS JUNIOR. A CRYSTAL STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND ADP  PROTEINS v.15;276,1998AAMP BINDING RESIDUE K - 57
2eck_A_502eck   RefM.B.BERRY,T.BILDERBACK,M.GLASER,G.N.PHILLIPS JUNIOR. A CRYSTAL STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND ADP  PROTEINS v.15;276,1998AAMP BINDING RESIDUE V - 59

Clusters included in this Subclass
CLUSTER: HH.5.0
CLUSTER: HH.6.5