ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 5.1.2

Subclass Accession number: 177
Subclass: 5.1.2
Type: HH alpha-alpha
DB: ArchDB-KI

Number of loops: 3

Average sequence ID (%) : 10.3 +/- 0.1
Average RMSD (Å) : 1.51 +/- 0.29

Consensus geometry

d (Å): 15

delta (°): 135-180

theta (°): 90-135

rho (°): 315-360

Consensus Sequence:	XXXXXhXDp
(φψ)-conformation:	aalppppaa

Pattern:	x	[IL]	x	x	x	[AK]	[AEK]	x	x	x	x	x	[GN]	x	[EL]	[LPV]	x	[D]	[DE]	x	[CIT]	[AIV]	x	[ILV]	x	[HRY]	x	x	x
Conservation:	-0.449	1.200	0.868	-0.532	-0.863	0.507	-0.118	-0.366	-0.697	-0.780	-1.028	-0.614	1.353	-0.863	-0.165	-0.532	-0.118	3.358	1.925	-0.366	-0.118	0.213	-0.201	0.875	-1.028	0.544	-0.449	-0.780	-0.780

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1cza_N_348	1cza	N	348	376	GLHNAKEILTRLGVEPSDDDCVSVQHVCT	HHHHHHHHHHHTT----HHHHHHHHHHHH	aaaaaaaaaaaagxbxxaaaaaaaaaaaa
1kkh_A_116	1kkh	A	121	149	TIGTIKAVSGFYNKELKDDEIAKLGYMVE	HHHHHHHHHHTTT----HHHHHHHHHHHH	aaaaaaaaaaaalbxxxaaaaaaaaaaaa
1zin_*_44	1zin	-	44	72	PLGLQAKQYMDRGDLVPDEVTIGIVRERL	HHHHHHHHHHHHT----HHHHHHHHHHHH	aaaaaaaaaaaavxxx-aaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	H - 373
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	T - 376
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	I - 377
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	V - 378
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	F - 380
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	R - 381
1cza_N_348	1cza	N	ADPADENOSINE-5'-DIPHOSPHATE	N - 384
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	A - 49
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	Y - 52
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	M - 53
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	G - 56
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	D - 57
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	L - 58
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	V - 59
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	P - 60
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	D - 61
1zin_*_44	1zin	*	AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE	T - 64

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1cza_N_348	1cza RefA.E.ALESHIN,C.KIRBY,X.LIU,G.P.BOURENKOV,H.D.BARTUNIK,H.J.FROMM,R.B.HONZATKO. CRYSTAL STRUCTURES OF MUTANT MONOMERIC HEXOKINASE I REVEAL MULTIPLE ADP BINDING SITES AND CONFORMATIONAL CHANGES RELEVANT TO ALLOSTERIC REGULATION J.MOL.BIOL. v.296;1001,2000	N	REGULATORY ADP BINDING RESIDUE	N - 384

Clusters included in this Subclass