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Information on SUBCLASS 2.1.2
Subclass Accession number: 2161
Subclass: 2.1.2 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 58

Average sequence ID (%) : 12.1 +/- 14.1
Average RMSD (Å) : 0.641 +/- 0.230

Consensus geometry
d (Å): 11 delta (°): 0-45 theta (°): 90-135 rho (°): 225-270
Consensus Sequence: XphpXp
(φψ)-conformation: aappaa
Pattern: x[adegknqrst]xx[adegknqrst][adegknqrst][aiklmtv][adenpqst]x[adegknqrst][adegkqrt]x
Conservation:-1.550-0.711-0.400-0.300-0.5090.1491.0382.222-0.8770.7050.473-0.240
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a41_*_2881a41   -289300LDVVSKTTFDEFHHHHTT--HHHHaaaaaaxxaaaa
1a8q_*_1741a8q   -181192WYMAMAQTIEGGHHHHTTS-HHHHaaaaaaxxaaaa
1aa7_A_1091aa7   A113124KEISLSYSAGALHHHHTTS-HHHHaaaaaabxaaaa
1axn_*_391axn   -4354ISILTERSNAQRHHHHTTS-HHHHaaaaaabxaaaa
1b3u_A_1011b3u   A112123RAISHEHSPSDLHHHHTTS-HHHHaaaaaaxxaaaa
1cb6_A_13161cb6   A13271338AIQNLRKSEEEVHHHHTTS-HHHHaaaaaaxxaaaa
1csn_*_2261csn   -234245GEKKQSTPLRELHHHHHHS-HHHHaaaaaaxxaaaa
1d2t_A_591d2t   A6475AAEDANLSSGGVHHHHHH--HHHHaaaaaapxaaaa
1dc1_A_801dc1   A8091DKAKKFLTEDDKHHHHTT--HHHHaaaaaaxxaaaa
1dd3_A_31dd3   A718IEAIEKLTVSELHHHHTTS-HHHHaaaaaaxxaaaa
1dmt_A_3481dmt   A355366KPILTKYSARDLHHHHTTS-HHHHaaaaaabxaaaa
1eex_A_1101eex   A114125VEVVSHMNVVEMHHHHTT--HHHHaaaaaabxaaaa
1eex_A_981eex   A102113VPLTTAMTPAKIHHHHTTS-HHHHaaaaaaxxaaaa
1eex_G_991eex   G108119AAELTAVPDDRIHHHHTTS-HHHHaaaaaaxxaaaa
1ef8_A_1841ef8   A195206AHHISEKAPLAIHHHHTTS-HHHHaaaaaaxxaaaa
1ey3_A_2181ey3   A226237AEKIANNSKIIVHHHHHTS-HHHHaaaaaaxpaaaa
1f7t_A_321f7t   A3546LDQYYELSEKRKHHHHTTS-HHHHaaaaaaxxaaaa
1fwx_A_611fwx   A6576RIHERTMSERTKHHHHTT--HHHHaaaaaapxaaaa
1gp6_A_891gp6   A99110GEEFFSLSVEEKHHHHHTS-HHHHaaaaaaxxaaaa
1hq1_A_251hq1   A2940EAIINSMTMKERHHHHHTS-HHHHaaaaaaxxaaaa
1i2t_A_10291i2t   A10331044TGMLLELSPAQLHHHHTTS-HHHHaaaaaaxxaaaa
1iex_A_121iex   A1728ADLLGRMTLAEKHHHHTT--HHHHaaaaaaxxaaaa
1iq8_A_2891iq8   A289300PQELREMPKEERHHHHTTS-HHHHaaaaaaxxaaaa
1j0h_A_3941j0h   A402413MHVLHSYPNNVNHHHHHTS-HHHHaaaaaabxaaaa
1j1n_A_3931j1n   A394405DYERQWTTPEAQHHHHTT--HHHHaaaaaaxxaaaa
1j7n_A_541j7n   A6071EKLLEKVPSDVLHHHHHTS-HHHHaaaaaaxpaaaa
1ko7_A_551ko7   A5869LSFYNLLPDEERHHHHHHS-HHHHaaaaaaxxaaaa
1m4z_A_1891m4z   A193204KAYIKKVEPREAHHHHTTS-HHHHaaaaaaxxaaaa
1m70_A_1661m70   A168179RGVAAKLSNKDIHHHHTT--HHHHaaaaaaxxaaaa
1m98_A_201m98   A2536IARFKQLSAEDQHHHHTTS-HHHHaaaaaaxpaaaa
1n00_A_361n00   A4051IDILGHRNAEQRHHHHTT--HHHHaaaaaabxaaaa
1n3l_A_1271n3l   A134145YRLSSVVTQHDSHHHHTTS-HHHHaaaaaaxxaaaa
1n69_A_431n69   A5970IQMMMHMQPKEIHHHHTTS-HHHHaaaaaabxaaaa
1nlf_A_801nlf   A8899HALGAHLSAEERHHHHTTS-HHHHaaaaaabxaaaa
1nni_1_801nni   18394KNALDFLSSEQFHHHHHH--HHHHaaaaaaxbaaaa
1o20_A_31o20   A1526WDVLRNATTREKHHHHTT--HHHHaaaaaaxxaaaa
1ogs_A_871ogs   A90101ALNILALSPPAQHHHHTTS-HHHHaaaaaaxxaaaa
1ov9_A_101ov9   A1425RAYARELTIEQLHHHHTTS-HHHHaaaaaabxaaaa
1oyz_A_141oyz   A1728YNQCKKLNDDELHHHHHTS-HHHHaaaaaaxxaaaa
1p1m_A_801p1m   A8192LPIEDRLTEKMAHHHHTT--HHHHaaaaaaxxaaaa
1pp7_U_61pp7   U819ASFTSRLPPEIVHHHHTTS-HHHHaaaaaabwaaaa
1ppr_M_2441ppr   M255266GRVIASVPKSTVHHHHTTS-HHHHaaaaaabxaaaa
1q0s_A_531q0s   A5970YKRLINVSWDDVHHHHTT--HHHHaaaaaabbaaaa
1q52_A_2381q52   A247258AAEINAKSPQAQHHHHTS-HHHHHaaaaaabxaaaa
1qb2_A_3651qb2   A376387MTIMDSMNDQELHHHHTTS-HHHHaaaaaaxxaaaa
1qc7_A_2461qc7   A250261QLVLREVDTRDLHHHHTSS-HHHHaaaaaabxaaaa
1qc7_A_2581qc7   A262273ALALKGASDELKHHHHTTS-HHHHaaaaaabxaaaa
1qc7_A_2701qc7   A274285EKIFKNMSKRAAHHHHTTS-HHHHaaaaaabxaaaa
1qgr_A_5731qgr   A589600QNVLRKVQHQDAHHHHTTS-HHHHaaaaaaxxaaaa
1qr0_A_141qr0   A1829ERFMTFISPEKRHHHHTTS-HHHHaaaaaaxxaaaa
1qyi_A_821qyi   A90101IDILKKLSHDEIHHHHTTS-HHHHaaaaaaxxaaaa
1rp3_A_1641rp3   A179190KEAVSKLPEREKHHHHTTS-HHHHaaaaaabxaaaa
1s3e_A_3471s3e   A349360ARKLARLTKEERHHHHTTS-HHHHaaaaaaxxaaaa
1sur_*_131sur   -2435NAELEKLDAEGRHHHHTTS-HHHHaaaaaaxxaaaa
1sur_*_51sur   -516LNALNELPKVDRHHHHHTS-HHHHaaaaaaxxaaaa
1utg_*_321utg   -4253KKVLDSLPQTTRHHHHTTS-HHHHaaaaaaxwaaaa
1uzb_A_731uzb   A8798FKTWKDWPQEDRHHHHTTS-HHHHaaaaaaxxaaaa
1v33_A_2021v33   A211222GYFILRIKLPHLHHHHTT--HHHHaaaaaaxbaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE K - 81
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE K - 84
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE F - 85
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE L - 86
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE D - 89
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE D - 90
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE K - 91
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE E - 93
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE S - 94
1dc1_A_801dc1   A     DIO1,4-DIETHYLENE DIOXIDE N - 97
1f7t_A_321f7t   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE S - 61
1f7t_A_321f7t   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE K - 62
1f7t_A_321f7t   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE A - 63
1iq8_A_2891iq8   A     ZNZINC ION H - 307
1iq8_A_2891iq8   A     ZNZINC ION N - 308
1iq8_A_2891iq8   A     ZNZINC ION W - 310
1iq8_A_2891iq8   A     ZNZINC ION V - 311
1j1n_A_3931j1n   A     MAW4-DEOXY-D-MANNURONIC ACID Y - 395
1j1n_A_3931j1n   A     MAVD-MANNURONIC ACID Y - 395
1j1n_A_3931j1n   A     MAW4-DEOXY-D-MANNURONIC ACID E - 396
1j1n_A_3931j1n   A     MAW4-DEOXY-D-MANNURONIC ACID W - 399
1ko7_A_551ko7   A     PO4PHOSPHATE ION T - 55
1ko7_A_551ko7   A     PO4PHOSPHATE ION T - 56
1ko7_A_551ko7   A     PO4PHOSPHATE ION E - 57
1m70_A_1661m70   A     HECHEME C I - 166
1m70_A_1661m70   A     HECHEME C M - 167
1m70_A_1661m70   A     HECHEME C V - 170
1m70_A_1661m70   A     HECHEME C L - 174
1m70_A_1661m70   A     HECHEME C L - 182
1m70_A_1661m70   A     CRYPROPANE-1,2,3-TRIOL Y - 185
1m70_A_1661m70   A     HECHEME C I - 186
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE Q - 36
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE L - 37
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE A - 38
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE I - 40
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE W - 41
1m98_A_201m98   A     HEQ3-[18-(4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-1-ENYL)-3,7, 12,16-TETRAMETHYL-OCTADECA-1,3,5,7,9,11,13,15, 17-NONAENYL]-2,4,4-TRIMETHYL-CYCLOHEX-2-ENONE Y - 44
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE M - 43
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE A - 44
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE I - 46
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE C - 47
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE Y - 50
1n69_A_431n69   A     PEHDI-STEAROYL-3-SN-PHOSPHATIDYLETHANOLAMINE I - 51
1nni_1_801nni   1     MSESELENOMETHIONINE G - 80
1nni_1_801nni   1     MSESELENOMETHIONINE L - 82
1nni_1_801nni   1     MSESELENOMETHIONINE K - 83
1nni_1_801nni   1     MSESELENOMETHIONINE L - 86
1nni_1_801nni   1     MSESELENOMETHIONINE F - 94
1o20_A_31o20   A     MSESELENOMETHIONINE L - 4
1o20_A_31o20   A     MSESELENOMETHIONINE A - 34
1o20_A_31o20   A     MSESELENOMETHIONINE L - 37
1p1m_A_801p1m   A     METMETHIONINE L - 81
1p1m_A_801p1m   A     METMETHIONINE E - 84
1pp7_U_61pp7   U     ZNZINC ION E - 7
1ppr_M_2441ppr   M     CLACHLOROPHYLL A Y - 247
1ppr_M_2441ppr   M     PIDPERIDININ Y - 247
1ppr_M_2441ppr   M     PIDPERIDININ V - 250
1ppr_M_2441ppr   M     CLACHLOROPHYLL A N - 251
1ppr_M_2441ppr   M     PIDPERIDININ N - 251
1ppr_M_2441ppr   M     CLACHLOROPHYLL A L - 254
1ppr_M_2441ppr   M     PIDPERIDININ L - 254
1ppr_M_2441ppr   M     PIDPERIDININ G - 255
1ppr_M_2441ppr   M     CLACHLOROPHYLL A V - 257
1ppr_M_2441ppr   M     PIDPERIDININ V - 257
1ppr_M_2441ppr   M     CLACHLOROPHYLL A I - 258
1ppr_M_2441ppr   M     PIDPERIDININ I - 258
1ppr_M_2441ppr   M     PIDPERIDININ P - 262
1ppr_M_2441ppr   M     PIDPERIDININ K - 263
1ppr_M_2441ppr   M     PIDPERIDININ V - 266
1ppr_M_2441ppr   M     PIDPERIDININ M - 267
1ppr_M_2441ppr   M     PIDPERIDININ V - 269
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) V - 269
1ppr_M_2441ppr   M     CLACHLOROPHYLL A Y - 270
1ppr_M_2441ppr   M     PIDPERIDININ Y - 270
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) Y - 270
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) M - 273
1ppr_M_2441ppr   M     DGDDIGALACTOSYL DIACYL GLYCEROL (DGDG) A - 274
1q0s_A_531q0s   A     SAHS-ADENOSYL-L-HOMOCYSTEINE I - 55
1qr0_A_141qr0   A     COACOENZYME A K - 28
1qr0_A_141qr0   A     COACOENZYME A K - 31
1qyi_A_821qyi   A     MSESELENOMETHIONINE F - 82
1qyi_A_821qyi   A     MSESELENOMETHIONINE I - 83
1qyi_A_821qyi   A     MSESELENOMETHIONINE V - 84
1qyi_A_821qyi   A     MSESELENOMETHIONINE F - 85
1qyi_A_821qyi   A     MSESELENOMETHIONINE L - 93
1qyi_A_821qyi   A     MSESELENOMETHIONINE E - 100
1qyi_A_821qyi   A     MSESELENOMETHIONINE I - 101
1qyi_A_821qyi   A     MSESELENOMETHIONINE E - 102
1qyi_A_821qyi   A     MSESELENOMETHIONINE A - 103
1uzb_A_731uzb   A     MRD(4R)-2-METHYLPENTANE-2,4-DIOL K - 91
1uzb_A_731uzb   A     MRD(4R)-2-METHYLPENTANE-2,4-DIOL D - 92

Clusters included in this Subclass
CLUSTER: HH.3.24
CLUSTER: HH.3.9
CLUSTER: HH.4.48
CLUSTER: HH.4.6
CLUSTER: HH.5.8