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Information on SUBCLASS 3.2.2
Subclass Accession number: 2276
Subclass: 3.2.2 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 2.3 (>75 %)  2.3.3 (>75 %)  2.3.3.1
GO : GO:0004108 (>75 %)  GO:0016746 (>75 %)  GO:0046912 (>75 %)  
SCOP : 48255 (>75 %)  48256 (>75 %)  48257 (>75 %)  
 Number of loops: 39

Average sequence ID (%) : 11.6 +/- 13.7
Average RMSD (Å) : 0.664 +/- 0.233

Consensus geometry
d (Å): 13 delta (°): 90-135 theta (°): 135-180 rho (°): 315-360
Consensus Sequence: XXcXpXp
(φψ)-conformation: aalppaa
Pattern: [acfgiklmtv]xxx[dgknqr][acfiklmtv][deknprst]x[adegknqrst][adegqt][acfiklmtv]
Conservation:-0.803-0.331-0.971-0.7301.9010.0861.169-1.403-0.1600.5170.723
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a0p_*_1301a0p   -142152LYATGLRVSELHHHH---HHHHaaaavpxaaaa
1bgx_T_6281bgx   T631641VFQEGRDIHTEHHHHT--HHHHaaaavbxaaaa
1ci4_A_561ci4   A6474KDTCGANAKQSHHHH---HHHHaaaavxxaaaa
1cli_A_2781cli   A284294QTAGNVEHHEMHHHHT--HHHHaaaavxxaaaa
1d2z_A_551d2z   A5969ATAVKLYPDQVHHHTT--HHHHaaaalxxaaaa
1d5t_A_1681d5t   A172182YRKFDLGQDVIHHHTT--HHHHaaaalxxaaaa
1ejg_A_71ejg   A1626CRLPGTPEALCHHTTT--HHHHaaaagpwaaaa
1epu_A_4181epu   A425435VQHAHIPAEEKHHHTT--HHHHaaaalxpaaaa
1evs_A_981evs   A98108LERSGLNIEDLHHHHT--HHHHaaaavxbaaaa
1f0j_A_2051f0j   A206216LKTFRISSDTFHHHTT--HHHHaaaalbxaaaa
1h2s_A_701h2s   A8898GLLAGLDSREFHHHHT--HHHHaaaavxxaaaa
1hn0_A_5881hn0   A595605LAISDKTQNESHHHHT--HHHHaaaavbxaaaa
1i9s_A_1311i9s   A142152VEKMDWSIEAAHHHH---HHHHaaaaNxxaaaa
1k2x_A_221k2x   A4252MLEAGESALDVHHHTT--HHHHaaaavxxaaaa
1k6y_A_41k6y   A1222HEKYHSNWRAMHHHH---HHHHaaaalxxaaaa
1kfs_A_7511kfs   A763773GLIYGMSAFGLHHHTT--HHHHaaaalxxaaaa
1m0l_A_811m0l   A98108ALLVDADQGTIHHHTT--HHHHaaaavpxaaaa
1n0u_A_1601n0u   A164174LLELQVSKEDLHHTS---HHHHaaaalxxaaaa
1n55_A_961n55   A99109RTYYGETDEIVHHHS---HHHHaaaavxxaaaa
1nbw_A_2161nbw   A220230ATFFGLSPEETHHHHT--HHHHaaaalxxaaaa
1nhp_*_4001nhp   -407417AIQAKMTIEDLHHHTT-BHHHHaaaavxbaaaa
1nk4_A_6991nk4   A711721GIVYGISDYGLHHHHT--HHHHaaaavxxaaaa
1o12_A_2951o12   A303313RKFTGCSITELHHHH---HHHHaaaavxxaaaa
1onw_A_3081onw   A318328VKDYDFSISDAHHHH---HHHHaaaavxxaaaa
1owf_A_51owf   A1323FDKLGLSKRDAHHHH---HHHHaaaavxxaaaa
1oxj_A_6301oxj   A633643LQSVGVTKGASHHHTT--HHHHaaaavxpaaaa
1q8c_A_1001q8c   A113123QKAHNTDKPLLHHHH---HHHHaaaavpxaaaa
1qo8_A_4421qo8   A446456AKSTGMKVADLHHHTT--HHHHaaaavxxaaaa
1qsa_A_2301qsa   A241251AQAQQLNEDQIHHHTT--HHHHaaaalxxaaaa
1qus_A_581qus   A6878VNKHGFDRQQLHHHH---HHHHaaaavxxaaaa
1r7i_A_151r7i   A2333GQLLGLSHDDVHHHHT--HHHHaaaavxxaaaa
1rkp_A_5841rkp   A585595VQNFQMKHEVLHHHTT--HHHHaaaalxxaaaa
1rqj_A_681rqj   A7787GHMFGVSTNTLHHHTT--HHHHaaaavxxaaaa
1so2_A_7091so2   A710720LEIFKIPTQQFHHHTT--HHHHaaaalxxaaaa
1tc3_C_2091tc3   C218228MKLLNVSLHEMHHHTT--HHHHaaaavxxaaaa
1un7_A_3211un7   A329339REFTNCSWTDIHHHH---HHHHaaaalxxaaaa
1upt_B_21961upt   B21992209TTVLKFPDDQTHHHTT--HHHHaaaalxxaaaa
1uzb_A_1131uzb   A121131VYEVGKNWVEAHHHH---HHHHaaaavxxaaaa
1zym_A_831zym   A93103IKDKHMTADAAHHHH---HHHHaaaalxxaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ci4_A_561ci4   A     MSESELENOMETHIONINE L - 81
1ci4_A_561ci4   A     MSESELENOMETHIONINE W - 84
1ci4_A_561ci4   A     MSESELENOMETHIONINE F - 88
1epu_A_4181epu   A     MSESELENOMETHIONINE L - 424
1epu_A_4181epu   A     MSESELENOMETHIONINE W - 436
1epu_A_4181epu   A     MSESELENOMETHIONINE I - 437
1epu_A_4181epu   A     MSESELENOMETHIONINE I - 438
1epu_A_4181epu   A     MSESELENOMETHIONINE N - 439
1h2s_A_701h2s   A     RETRETINAL Y - 73
1h2s_A_701h2s   A     RETRETINAL D - 75
1h2s_A_701h2s   A     RETRETINAL W - 76
1h2s_A_701h2s   A     RETRETINAL T - 79
1h2s_A_701h2s   A     RETRETINAL T - 80
1h2s_A_701h2s   A     RETRETINAL I - 83
1h2s_A_701h2s   A     BOGB-OCTYLGLUCOSIDE F - 86
1h2s_A_701h2s   A     BOGB-OCTYLGLUCOSIDE L - 89
1h2s_A_701h2s   A     BOGB-OCTYLGLUCOSIDE L - 90
1h2s_A_701h2s   A     RETRETINAL V - 108
1h2s_A_701h2s   A     RETRETINAL M - 109
1h2s_A_701h2s   A     RETRETINAL A - 111
1h2s_A_701h2s   A     RETRETINAL G - 112
1h2s_A_701h2s   A     RETRETINAL F - 113
1k2x_A_221k2x   A     CMES,S-(2-HYDROXYETHYL)THIOCYSTEINE A - 31
1k2x_A_221k2x   A     CMES,S-(2-HYDROXYETHYL)THIOCYSTEINE I - 35
1k2x_A_221k2x   A     CMES,S-(2-HYDROXYETHYL)THIOCYSTEINE R - 58
1k2x_A_221k2x   A     CMES,S-(2-HYDROXYETHYL)THIOCYSTEINE L - 59
1k2x_A_221k2x   A     CMES,S-(2-HYDROXYETHYL)THIOCYSTEINE L - 60
1k2x_A_221k2x   A     CMES,S-(2-HYDROXYETHYL)THIOCYSTEINE E - 61
1k6y_A_41k6y   A     ZNZINC ION H - 12
1k6y_A_41k6y   A     ZNZINC ION H - 16
1k6y_A_41k6y   A     ZNZINC ION S - 17
1kfs_A_7511kfs   A     ZNZINC ION Y - 766
1m0l_A_811m0l   A     RETRETINAL Y - 83
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL A - 84
1m0l_A_811m0l   A     RETRETINAL D - 85
1m0l_A_811m0l   A     RETRETINAL W - 86
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL L - 87
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL F - 88
1m0l_A_811m0l   A     RETRETINAL T - 89
1m0l_A_811m0l   A     RETRETINAL T - 90
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL P - 91
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL L - 92
1m0l_A_811m0l   A     RETRETINAL L - 93
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL L - 95
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL I - 108
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL V - 112
1m0l_A_811m0l   A     LI11-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL G - 116
1m0l_A_811m0l   A     RETRETINAL M - 118
1m0l_A_811m0l   A     RETRETINAL I - 119
1m0l_A_811m0l   A     RETRETINAL T - 121
1m0l_A_811m0l   A     RETRETINAL G - 122
1m0l_A_811m0l   A     RETRETINAL L - 123
1n55_A_961n55   A     PGA2-PHOSPHOGLYCOLIC ACID E - 97
1n55_A_961n55   A     GOLGLYCEROL R - 98
1n55_A_961n55   A     GOLGLYCEROL C - 117
1o12_A_2951o12   A     MSESELENOMETHIONINE V - 299
1o12_A_2951o12   A     MSESELENOMETHIONINE I - 310
1o12_A_2951o12   A     MSESELENOMETHIONINE T - 311
1o12_A_2951o12   A     MSESELENOMETHIONINE L - 313
1o12_A_2951o12   A     MSESELENOMETHIONINE A - 314
1o12_A_2951o12   A     MSESELENOMETHIONINE K - 315
1o12_A_2951o12   A     MSESELENOMETHIONINE S - 317
1q8c_A_1001q8c   A     IODIODIDE ION K - 114
1q8c_A_1001q8c   A     IODIODIDE ION A - 115
1q8c_A_1001q8c   A     IODIODIDE ION H - 116
1q8c_A_1001q8c   A     IODIODIDE ION K - 120
1q8c_A_1001q8c   A     IODIODIDE ION P - 121
1q8c_A_1001q8c   A     IODIODIDE ION I - 124
1r7i_A_151r7i   A     GOLGLYCEROL L - 26
1r7i_A_151r7i   A     GOLGLYCEROL G - 27
1r7i_A_151r7i   A     GOLGLYCEROL L - 28
1rqj_A_681rqj   A     IPRISOPENTYL PYROPHOSPHATE L - 68
1rqj_A_681rqj   A     IPRISOPENTYL PYROPHOSPHATE R - 69
1rqj_A_681rqj   A     IPRISOPENTYL PYROPHOSPHATE E - 95
1rqj_A_681rqj   A     IPRISOPENTYL PYROPHOSPHATE H - 98
1rqj_A_681rqj   A     IPRISOPENTYL PYROPHOSPHATE S - 101
1rqj_A_681rqj   A     RIS1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID S - 101
1rqj_A_681rqj   A     IPRISOPENTYL PYROPHOSPHATE L - 102
1rqj_A_681rqj   A     RIS1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID L - 102
1rqj_A_681rqj   A     MGMAGNESIUM ION D - 105
1rqj_A_681rqj   A     RIS1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID D - 105
1un7_A_3211un7   A     2PENONAETHYLENE GLYCOL E - 330
1un7_A_3211un7   A     2PENONAETHYLENE GLYCOL F - 331
1un7_A_3211un7   A     2PENONAETHYLENE GLYCOL T - 332
1un7_A_3211un7   A     2PENONAETHYLENE GLYCOL N - 333
1upt_B_21961upt   B     MSESELENOMETHIONINE K - 2196
1upt_B_21961upt   B     MSESELENOMETHIONINE V - 2197
1upt_B_21961upt   B     MSESELENOMETHIONINE I - 2198
1upt_B_21961upt   B     MSESELENOMETHIONINE T - 2199
1upt_B_21961upt   B     MSESELENOMETHIONINE F - 2204
1upt_B_21961upt   B     MSESELENOMETHIONINE Q - 2208
1upt_B_21961upt   B     MSESELENOMETHIONINE K - 2211
1upt_B_21961upt   B     MSESELENOMETHIONINE I - 2212
1upt_B_21961upt   B     MSESELENOMETHIONINE R - 2215
1upt_B_21961upt   B     MSESELENOMETHIONINE E - 2216
1upt_B_21961upt   B     MSESELENOMETHIONINE D - 2217
1upt_B_21961upt   B     MSESELENOMETHIONINE A - 2218
1upt_B_21961upt   B     MSESELENOMETHIONINE R - 2219
1uzb_A_1131uzb   A     MRD(4R)-2-METHYLPENTANE-2,4-DIOL Y - 144
1uzb_A_1131uzb   A     MRD(4R)-2-METHYLPENTANE-2,4-DIOL R - 147
1uzb_A_1131uzb   A     MRD(4R)-2-METHYLPENTANE-2,4-DIOL A - 148
1uzb_A_1131uzb   A     MRD(4R)-2-METHYLPENTANE-2,4-DIOL A - 149
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1un7_A_3211un7   A AC32PE BINDING SITE FOR CHAIN AF - 331
1un7_A_3211un7   A AC32PE BINDING SITE FOR CHAIN AT - 332
1un7_A_3211un7   A AC32PE BINDING SITE FOR CHAIN AN - 333
1uzb_A_1131uzb   A AC2MRD BINDING SITE FOR CHAIN AR - 147
1uzb_A_1131uzb   A AC2MRD BINDING SITE FOR CHAIN AA - 148

Clusters included in this Subclass
CLUSTER: HH.2.71
CLUSTER: HH.3.13
CLUSTER: HH.4.7
CLUSTER: HH.5.13