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Information on SUBCLASS 4.3.1
Subclass Accession number: 2373
Subclass: 4.3.1 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 2.7 (>75 %)  2.7.1 (>75 %)  2.7.1.112
GO : GO:0004672 (>75 %)  GO:0005524 (>75 %)  GO:0016301 (>75 %)  GO:0016772 (>75 %)  GO:0016773 (>75 %)  GO:0030554 (>75 %)  
SCOP : 48370 (>75 %)  48370 (>75 %)  48452 (>75 %)  48453 (>75 %)  56111 (>75 %)  56112 (>75 %)  88854 (>75 %)  
 Number of loops: 28

Average sequence ID (%) : 15.6 +/- 15.3
Average RMSD (Å) : 0.514 +/- 0.299

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 135-180 rho (°): 180-225
Consensus Sequence: pXpPppXX
(φψ)-conformation: aabaapaa
Pattern: [afilvy][adegknqrs]x[acfgilvy]x[adegknqrst][acfgilmtv][cikltv][adeknqrs]x[adeknqr][apv][dehknqrsty][dehnrswy]xx[agilvy][hkqrwy]x
Conservation:0.528-0.479-1.119-0.232-0.710-0.161-0.5040.3250.702-0.6010.5833.505-0.0870.252-1.006-0.6160.276-0.146-0.510
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a17_*_1121a17   -116134LRDYETVVKVKPHDKDAKMHHHHHHHHHHSTT-HHHHHaaaaaaaaaabaaxaaaaa
1a17_*_441a17   -4866IKFYSQAIELNPSNAIYYGHHHHHHHHHHSTT-HHHHHaaaaaaaaaabaaxaaaaa
1a17_*_781a17   -82100LGDATRAIELDKKYIKGYYHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1ciy_*_901ciy   -110128YAESFREWEADPTNPALREHHHHHHHHHHSTT-HHHHHaaaaaaaaaabaapaaaaa
1elr_A_2411elr   A245263LKHYDKAKELDPTNMTYITHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1elw_A_201elw   A2442LQCYSEAIKLDPHNHVLYSHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1elw_A_541elw   A5876YEDGCKTVDLKPDWGKGYSHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1elw_A_881elw   A92110KRTYEEGLKHEANNPQLKEHHHHHHHHTT-TT-HHHHHaaaaaaaaaabaaxaaaaa
1fch_A_3141fch   A318336VLLFEAAVQQDPKHMEAWQHHHHHHHHHS-TT-HHHHHaaaaaaaaaabaaxaaaaa
1fch_A_3481fch   A352370ISALRRCLELKPDNQTALMHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1fch_A_4671fch   A471489VDCFTAALSVRPNDYLLWNHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1fch_A_5011fch   A505523VAAYRRALELQPGYIRSRYHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1h6g_A_4541h6g   A464482VINAALALAAKPQSKLAQEHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1hh8_A_531hh8   A5775EKAFTRSINRDKHLAVAYFHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1hxi_A_3651hxi   A369387ALAFEAVCQKEPEREEAWRHHHHHHHHHHSTT-HHHHHaaaaaaaaaabaaxaaaaa
1ihg_A_2891ihg   A293311VDSCLEALEIDPSNTKALYHHHHHHHHTT-TT-HHHHHaaaaaaaaaabaaxaaaaa
1ihg_A_3231ihg   A327345LADLKKAQEIAPEDKAIQAHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1ld8_A_1141ld8   A117135FKLTRDAIELNAANYTVWHHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1ld8_A_1851ld8   A186204LEFIADILNQDAKNYHAWQHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaapaaaaa
1ld8_A_2191ld8   A220238LQYVDQLLKEDVRNNSVWNHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1ld8_A_2531ld8   A260278VQYTLEMIKLVPHNESAWNHHHHHHHHHHSTT-HHHHHaaaaaaaaaabaaxaaaaa
1lki_*_761lki   -95113TNITRDQKVLNPTAVSLQVHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1lrz_A_2451lrz   A263281LNKALKDIEKRPENKKAHNHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1nzn_A_901nzn   A94112LKYVRGLLQTEPQNNQAKEHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1qh5_A_1761qh5   A177195INNLKFARHVEPGNAAIREHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1qsa_A_551qsa   A5573AVTVTNFVRANPTLPPARTHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
1rke_A_681rke   A88106LVQAAQMLQSDPYSVPARDHHHHHHHHTT-TT-HHHHHaaaaaaaaaabaapaaaaa
1ujk_A_1091ujk   A116134LELLYSWTVGLPEEVKIAEHHHHHHHHHH-TT-HHHHHaaaaaaaaaabaaxaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1elr_A_2411elr   A     NINICKEL (II) ION T - 243
1elr_A_2411elr   A     NINICKEL (II) ION H - 247
1elw_A_201elw   A     NINICKEL (II) ION P - 35
1elw_A_201elw   A     NINICKEL (II) ION H - 36
1elw_A_541elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL V - 65
1elw_A_541elw   A     NINICKEL (II) ION P - 69
1elw_A_541elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL P - 69
1elw_A_541elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL D - 70
1elw_A_541elw   A     NINICKEL (II) ION Y - 75
1elw_A_541elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL Y - 75
1elw_A_881elw   A     NINICKEL (II) ION E - 97
1elw_A_881elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL E - 97
1elw_A_881elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL G - 98
1elw_A_881elw   A     NINICKEL (II) ION K - 100
1elw_A_881elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL K - 100
1elw_A_881elw   A     NINICKEL (II) ION H - 101
1elw_A_881elw   A     TRS2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL H - 101
1h6g_A_4541h6g   A     MSESELENOMETHIONINE A - 454
1h6g_A_4541h6g   A     CACALCIUM ION A - 454
1h6g_A_4541h6g   A     MSESELENOMETHIONINE S - 455
1h6g_A_4541h6g   A     CACALCIUM ION S - 455
1h6g_A_4541h6g   A     MSESELENOMETHIONINE Q - 456
1h6g_A_4541h6g   A     CACALCIUM ION Q - 456
1h6g_A_4541h6g   A     MSESELENOMETHIONINE L - 457
1h6g_A_4541h6g   A     MSESELENOMETHIONINE V - 464
1h6g_A_4541h6g   A     MSESELENOMETHIONINE I - 465
1h6g_A_4541h6g   A     MSESELENOMETHIONINE A - 467
1h6g_A_4541h6g   A     CACALCIUM ION A - 467
1h6g_A_4541h6g   A     MSESELENOMETHIONINE A - 468
1h6g_A_4541h6g   A     CACALCIUM ION A - 468
1h6g_A_4541h6g   A     MSESELENOMETHIONINE L - 469
1h6g_A_4541h6g   A     MSESELENOMETHIONINE L - 471
1h6g_A_4541h6g   A     CACALCIUM ION L - 471
1h6g_A_4541h6g   A     MSESELENOMETHIONINE L - 479
1h6g_A_4541h6g   A     MSESELENOMETHIONINE A - 480
1h6g_A_4541h6g   A     CACALCIUM ION A - 480
1h6g_A_4541h6g   A     MSESELENOMETHIONINE Q - 481
1h6g_A_4541h6g   A     CACALCIUM ION Q - 481
1h6g_A_4541h6g   A     MSESELENOMETHIONINE E - 482
1h6g_A_4541h6g   A     CACALCIUM ION E - 482
1hxi_A_3651hxi   A     MSESELENOMETHIONINE L - 365
1hxi_A_3651hxi   A     MSESELENOMETHIONINE E - 367
1hxi_A_3651hxi   A     MSESELENOMETHIONINE A - 368
1hxi_A_3651hxi   A     MSESELENOMETHIONINE A - 369
1hxi_A_3651hxi   A     MSESELENOMETHIONINE A - 371
1hxi_A_3651hxi   A     MSESELENOMETHIONINE F - 372
1hxi_A_3651hxi   A     MSESELENOMETHIONINE E - 373
1hxi_A_3651hxi   A     MSESELENOMETHIONINE A - 374
1hxi_A_3651hxi   A     MSESELENOMETHIONINE V - 375
1hxi_A_3651hxi   A     MSESELENOMETHIONINE Q - 377
1hxi_A_3651hxi   A     MSESELENOMETHIONINE K - 378
1hxi_A_3651hxi   A     MSESELENOMETHIONINE E - 379
1hxi_A_3651hxi   A     MSESELENOMETHIONINE R - 382
1hxi_A_3651hxi   A     MSESELENOMETHIONINE E - 384
1hxi_A_3651hxi   A     MSESELENOMETHIONINE A - 385
1hxi_A_3651hxi   A     MSESELENOMETHIONINE S - 388
1hxi_A_3651hxi   A     MGMAGNESIUM ION A - 394
1hxi_A_3651hxi   A     MGMAGNESIUM ION E - 395
1ld8_A_1851ld8   A     FPPFARNESYL DIPHOSPHATE D - 196
1ld8_A_1851ld8   A     FPPFARNESYL DIPHOSPHATE K - 198
1ld8_A_1851ld8   A     FPPFARNESYL DIPHOSPHATE N - 199
1ld8_A_1851ld8   A     FPPFARNESYL DIPHOSPHATE Y - 200
1ld8_A_1851ld8   A     FPPFARNESYL DIPHOSPHATE H - 201
1ld8_A_1851ld8   A     U49(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1, 6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE H - 201
1ld8_A_2191ld8   A     SUCSUCROSE Y - 241
1ld8_A_2191ld8   A     SUCSUCROSE S - 245
1ld8_A_2531ld8   A     SUCSUCROSE G - 282
1ld8_A_2531ld8   A     SUCSUCROSE I - 283
1nzn_A_901nzn   A     MSESELENOMETHIONINE Y - 90
1nzn_A_901nzn   A     MSESELENOMETHIONINE E - 91
1nzn_A_901nzn   A     MSESELENOMETHIONINE L - 94
1nzn_A_901nzn   A     MSESELENOMETHIONINE L - 116
1nzn_A_901nzn   A     MSESELENOMETHIONINE I - 117
1nzn_A_901nzn   A     MSESELENOMETHIONINE D - 118
1nzn_A_901nzn   A     MSESELENOMETHIONINE K - 119
1qh5_A_1761qh5   A     GTTGLUTATHIONE N - 178
1qh5_A_1761qh5   A     GTTGLUTATHIONE N - 179

Clusters included in this Subclass
CLUSTER: HH.5.3
CLUSTER: HH.6.168