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Information on SUBCLASS 8.2.1
Subclass Accession number: 2523
Subclass: 8.2.1 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 1.1 (>75 %)  1.1 (>75 %)  1.1.1 (>75 %)  1.1.1 (>75 %)  
GO : GO:0003700 (>75 %)  GO:0003707 (>75 %)  GO:0004872 (>75 %)  GO:0004879 (>75 %)  GO:0016614 (>75 %)  GO:0016614 (>75 %)  GO:0016616 (>75 %)  GO:0016616 (>75 %)  
SCOP : 48507 (>75 %)  48508 (>75 %)  48509 (>75 %)  51734 (>75 %)  51734 (>75 %)  51735 (>75 %)  51735 (>75 %)  51751 (>75 %)  51751 (>75 %)  
 Number of loops: 6

Average sequence ID (%) : 33.3 +/- 22.1
Average RMSD (Å) : 0.483 +/- 0.117

Consensus geometry
d (Å): 11 delta (°): 45-90 theta (°): 90-135 rho (°): 270-315
Consensus Sequence: KphPGFXpLpXX
(φψ)-conformation: aappgaaappaa
Pattern: [FLMVW]xx[CFL][qsty][dekq][lm][alv][DSTV][EKNSY][cehs][ILV]xx[ILMV][IKTV][EGQS][FWY][AT][EK][kmr][IL][P][G][FY]x[DEGNT][L][dst]x[aef][D][Q][iv][altv][L][FL][EKQ][ags][ACGS][acvw][HILMV][DE][AILV][FILM][FMVY][LMT][gr]
Conservation:-0.442-0.999-1.274-0.280-0.777-0.670-0.129-0.555-0.498-0.689-0.8450.518-0.865-0.8960.311-0.568-0.3501.1280.3940.907-0.2870.6462.8412.2801.702-1.186-0.5261.158-0.789-1.255-0.9052.2801.719-0.198-0.8651.1580.4090.472-0.612-0.427-0.945-0.5111.157-0.065-0.011-0.189-0.013-0.458
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1fcy_A_2241fcy   A227274WDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRHHHHHHHHHHHHHHHHHHHHTSTTGGGS-HHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpvaaaxpaaaaaaaaaaaaaaaaaaa
1ie9_A_2271ie9   A227274LPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRHHHHHHHHHHHHHHHHHHHHTSTTGGGS-HHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpgaaaxxaaaaaaaaaaaaaaaaaaa
1osh_A_2871osh   A288335FLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRHHHHHHHHHHHHHHHHHHHHTSTTGGGS-HHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpvaaaxpaaaaaaaaaaaaaaaaaaa
1pdu_A_3521pdu   A356403VQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRHHHHHHHHHHHHHHHHHHHTTSTTGGGS-HHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpvaaaxxaaaaaaaaaaaaaaaaaaa
1qkm_A_2931qkm   A295342MMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGHHHHHHHHHHHHHHHHHHHHHSTTGGGS-HHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpgaaaxxaaaaaaaaaaaaaaaaaaa
2prg_A_2772prg   A282329FQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMHHHHHHHHHHHHHHHHHHHHHSTTGGGS-HHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaaaaaaaaaaxpgaaaxpaaaaaaaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID W - 227
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID F - 230
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID S - 231
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID L - 233
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID A - 234
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE K - 236
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID C - 237
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE I - 238
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE I - 239
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE K - 240
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE V - 242
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE E - 243
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE I - 260
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE L - 263
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE K - 264
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE A - 265
1fcy_A_2241fcy   A     LMUDODECYL-ALPHA-D-MALTOSIDE C - 267
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID L - 268
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID I - 270
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID L - 271
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID M - 272
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID R - 274
1fcy_A_2241fcy   A     5646-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID I - 275
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL L - 227
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL L - 230
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL A - 231
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL L - 233
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL V - 234
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL S - 237
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL I - 268
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL V - 270
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL I - 271
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL M - 272
1ie9_A_2271ie9   A     VDX5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL R - 274
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE N - 287
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE F - 288
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE I - 290
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE L - 291
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE T - 292
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE M - 294
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE A - 295
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE H - 298
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE M - 332
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE F - 333
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE S - 336
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE I - 339
1osh_A_2871osh   A     FEXMETHYL 3-[3-(BENZOYL{[4'-(DIMETHYLAMINO)-1,1'-BIPHENYL -4-YL]METHYL}AMINO)PHENYL]PROPANOATE F - 340
1qkm_A_2931qkm   A     GENGENISTEIN M - 295
1qkm_A_2931qkm   A     GENGENISTEIN L - 298
1qkm_A_2931qkm   A     GENGENISTEIN T - 299
1qkm_A_2931qkm   A     GENGENISTEIN L - 301
1qkm_A_2931qkm   A     GENGENISTEIN A - 302
1qkm_A_2931qkm   A     GENGENISTEIN E - 305
1qkm_A_2931qkm   A     GENGENISTEIN W - 335
1qkm_A_2931qkm   A     GENGENISTEIN M - 336
1qkm_A_2931qkm   A     GENGENISTEIN L - 339
1qkm_A_2931qkm   A     GENGENISTEIN M - 340
1qkm_A_2931qkm   A     GENGENISTEIN G - 342
1qkm_A_2931qkm   A     GENGENISTEIN L - 343
1qkm_A_2931qkm   A     GENGENISTEIN R - 346
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) R - 280
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) I - 281
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) F - 282
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) G - 284
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) C - 285
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) Q - 286
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) R - 288
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) S - 289
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) H - 323
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) I - 326
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) Y - 327
2prg_A_2772prg   A     BRL2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) L - 330
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
2prg_A_2772prg   A LB1THESE RESIDUES ARE INVOLVED IN LIGAND BINDING.R - 288
2prg_A_2772prg   A CA1RESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.T - 297
2prg_A_2772prg   A CA1RESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.K - 301
2prg_A_2772prg   A CA1RESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.L - 311
2prg_A_2772prg   A CA1RESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.Q - 314
2prg_A_2772prg   A CA1RESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.V - 315
2prg_A_2772prg   A CA1RESIDUES INVOLVED IN BINDING THE LXXLL COACTIVATOR HELIX.L - 318
2prg_A_2772prg   A LB1THESE RESIDUES ARE INVOLVED IN LIGAND BINDING.H - 323
2prg_A_2772prg   A LB1THESE RESIDUES ARE INVOLVED IN LIGAND BINDING.Y - 327
2prg_A_2772prg   A LB1THESE RESIDUES ARE INVOLVED IN LIGAND BINDING.L - 330

Clusters included in this Subclass
CLUSTER: HH.9.3