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Information on SUBCLASS 4.2.2
Subclass Accession number: 272
Subclass: 4.2.2 PSSM
Type: HE alpha-beta
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>75 %)  3.4.23 (>75 %)  
SCOP : 50629 (>75 %)  50630 (>75 %)  50646 (>75 %)  
 Number of loops: 17

Average sequence ID (%) : 17.6 +/- 19.3
Average RMSD (Å) : 0.571 +/- 0.234

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 135-180 rho (°): 90-135
Consensus Sequence: XXcXhpXh
(φψ)-conformation: aalababb
Pattern: [adeknqs]x[afilpvy]x[aegkqs][dgk]x[acfivy][adekq]x[agimv]
Conservation:-0.348-0.9590.485-0.5230.1702.392-1.1530.1360.046-0.9360.689
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1afw_A_1271afw   A137147NKIKVGQIDIGHHHHTTS-SEEaaaaavababb
1bam_*_1171bam   -129139LGLKHGEIDLAHHHHTTS-SEEaaaaavababb
1ei1_A_341ei1   A4959DEALAGHCKEIHHHHTT---EEaaaaavababb
1ezi_A_311ezi   A3848AAISSKCFDRIHHHHH---SEEaaaaavababb
1hnj_A_1141hnj   A124134QYVKSGAVKYAHHHHTTS-SEEaaaaavababb
1hzp_A_1141hzp   A124134DMIRGGGAATMHHHHTTS-SEEaaaaavababb
1i7q_A_2421i7q   A254264EAIRQGEIFQVHHHHHTS-SEEaaaaavababb
1k0g_A_1901k0g   A202212EYLHSGDCYQVHHHHTTS-SEEaaaaavababb
1naq_A_211naq   A3040KVLAEKLAACAHHHHTTS-SEEaaaaalababb
1o63_A_1351o63   A135145LAPIAGLSDLIHHHHHTS-SEEaaaaavababb
1o98_A_3761o98   A385395KEIEADKYDAIHHHHTT--SEEaaaaalababb
1rxx_A_2461rxx   A255265SLFAKGAAERVHHHHTTS-SEEaaaaavababb
1s14_A_10331s14   A10451055DEALAGHAKRVHHHHTTS-SEEaaaaavababb
1s16_A_10331s16   A10451055DEALAGHAKRVHHHHTT--SEEaaaaavababb
1sdo_A_1441sdo   A147157AFYVSDKIDVGHHHHTTS-SEEaaaaavababb
1ub7_A_1121ub7   A122132ALVEAGLAQKVHHHHTTS-SEEaaaaavababb
2reb_*_1222reb   -131141ALARSGAVDVIHHHHHS---EEaaaaavababb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ei1_A_341ei1   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER E - 42
1ei1_A_341ei1   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER V - 43
1ei1_A_341ei1   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER N - 46
1ei1_A_341ei1   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER A - 47
1ei1_A_341ei1   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER D - 49
1ei1_A_341ei1   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER E - 50
1ei1_A_341ei1   A     GOLGLYCEROL E - 50
1ezi_A_311ezi   A     MSESELENOMETHIONINE L - 31
1ezi_A_311ezi   A     MSESELENOMETHIONINE H - 34
1hzp_A_1141hzp   A     GOLGLYCEROL K - 141
1i7q_A_2421i7q   A     ILGGLUTAMYL GROUP Q - 258
1i7q_A_2421i7q   A     ILGGLUTAMYL GROUP G - 259
1i7q_A_2421i7q   A     ILGGLUTAMYL GROUP E - 260
1i7q_A_2421i7q   A     ILGGLUTAMYL GROUP F - 262
1i7q_A_2421i7q   A     BEZBENZOIC ACID Q - 263
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID T - 23
1naq_A_211naq   A     HGMERCURY (II) ION L - 27
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID L - 27
1naq_A_211naq   A     HGMERCURY (II) ION E - 34
1naq_A_211naq   A     HGMERCURY (II) ION L - 36
1naq_A_211naq   A     HGMERCURY (II) ION A - 38
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID A - 38
1naq_A_211naq   A     HGMERCURY (II) ION C - 39
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID C - 39
1naq_A_211naq   A     HGMERCURY (II) ION A - 40
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID A - 40
1naq_A_211naq   A     HGMERCURY (II) ION T - 41
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID T - 41
1naq_A_211naq   A     HGMERCURY (II) ION S - 48
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID S - 48
1naq_A_211naq   A     HGMERCURY (II) ION L - 49
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID L - 49
1naq_A_211naq   A     HGMERCURY (II) ION Y - 50
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID Y - 50
1o63_A_1351o63   A     MSESELENOMETHIONINE L - 135
1o63_A_1351o63   A     MSESELENOMETHIONINE V - 146
1o98_A_3761o98   A     MNMANGANESE (II) ION N - 398
1rxx_A_2461rxx   A     MSESELENOMETHIONINE R - 246
1rxx_A_2461rxx   A     MSESELENOMETHIONINE Q - 247
1rxx_A_2461rxx   A     MSESELENOMETHIONINE I - 249
1rxx_A_2461rxx   A     MSESELENOMETHIONINE G - 250
1rxx_A_2461rxx   A     MSESELENOMETHIONINE Q - 251
1rxx_A_2461rxx   A     MSESELENOMETHIONINE A - 253
1rxx_A_2461rxx   A     MSESELENOMETHIONINE Q - 254
1rxx_A_2461rxx   A     MSESELENOMETHIONINE F - 257
1rxx_A_2461rxx   A     MSESELENOMETHIONINE V - 267
1rxx_A_2461rxx   A     MSESELENOMETHIONINE A - 268
1rxx_A_2461rxx   A     MSESELENOMETHIONINE G - 269
1s14_A_10331s14   A     NOVNOVOBIOCIN V - 1039
1s14_A_10331s14   A     NOVNOVOBIOCIN D - 1041
1s14_A_10331s14   A     NOVNOVOBIOCIN N - 1042
1s14_A_10331s14   A     NOVNOVOBIOCIN S - 1043
1s14_A_10331s14   A     NOVNOVOBIOCIN D - 1045
1s14_A_10331s14   A     NOVNOVOBIOCIN E - 1046
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER E - 1038
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER V - 1039
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER D - 1041
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER N - 1042
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER S - 1043
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER D - 1045
1s16_A_10331s16   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER E - 1046
1ub7_A_1121ub7   A     CEAS-HYDROXY-CYSTEINE G - 112
1ub7_A_1121ub7   A     CEAS-HYDROXY-CYSTEINE W - 113
1ub7_A_1121ub7   A     CEAS-HYDROXY-CYSTEINE I - 114
1ub7_A_1121ub7   A     GOLGLYCEROL H - 121
1ub7_A_1121ub7   A     GOLGLYCEROL E - 125
1ub7_A_1121ub7   A     GOLGLYCEROL G - 127
1ub7_A_1121ub7   A     GOLGLYCEROL L - 128
1ub7_A_1121ub7   A     GOLGLYCEROL A - 129
1ub7_A_1121ub7   A     CEAS-HYDROXY-CYSTEINE E - 138

Clusters included in this Subclass
CLUSTER: HE.4.55
CLUSTER: HE.4.67
CLUSTER: HE.6.69
CLUSTER: HE.6.70