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Information on SUBCLASS 13.8.1
Subclass Accession number: 3595
Subclass: 13.8.1 PSSM
Type: EH beta-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>75 %)  3.4.24 (>75 %)  3.4.24.7
GO : GO:0004175 (>75 %)  GO:0004222 (>75 %)  GO:0005509 (>75 %)  GO:0008233 (>75 %)  GO:0008237 (>75 %)  GO:0008270 (>75 %)  GO:0046914 (>75 %)  
SCOP : 55485 (>75 %)  55486 (>75 %)  55528 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 72.4 +/- -28.0
Average RMSD (Å) : 0.200 +/- 0.100

Consensus geometry
d (Å): 13 delta (°): 90-135 theta (°): 135-180 rho (°): 270-315
Consensus Sequence: FDXpEpWTcpXXpYNLX
(φψ)-conformation: bpaapppbabappwpaa
Pattern: [A][H][F][D][AE][DE][E][RT][W][T][KN][NT]x[AR][DEN][Y][N][L][FHY]x[V][A][A][H][E][FL][G][H][S]
Conservation:-0.2231.4930.6350.635-1.175-0.3180.206-1.0782.7800.206-0.700-0.746-1.270-1.175-0.8431.0640.635-0.223-0.557-1.389-0.223-0.223-0.2231.4930.206-0.8860.6351.493-0.223
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1fbl_*_1951fbl   -195223AHFDEDERWTKNFRDYNLYRVAAHELGHSEEEETTS--BSSSSS-BHHHHHHHHHHHHbbbxaaxxxbabaxpvxaaaaaaaaaaaa
1hfc_*_1951hfc   -195223AHFDEDERWTNNFREYNLHRVAAHELGHSEEEETTS--BSSSSS-BHHHHHHHHHHHHbbbxaaxxxbabaxxwxaaaaaaaaaaaa
1i76_A_1741i76   A174202AHFDAEETWTNTSANYNLFLVAAHEFGHSEEEETTS--BSSSSS-BHHHHHHHHHHHHbbbxaaxxbbabaxxwxaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1fbl_*_1951fbl   *     ZNZINC ION H - 196
1fbl_*_1951fbl   *     CACALCIUM ION D - 198
1fbl_*_1951fbl   *     CACALCIUM ION E - 199
1fbl_*_1951fbl   *     CACALCIUM ION D - 200
1fbl_*_1951fbl   *     CACALCIUM ION E - 201
1fbl_*_1951fbl   *     CACALCIUM ION R - 202
1fbl_*_1951fbl   *     CACALCIUM ION W - 203
1fbl_*_1951fbl   *     HTAN-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE Y - 210
1fbl_*_1951fbl   *     HTAN-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE R - 214
1fbl_*_1951fbl   *     HTAN-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE V - 215
1fbl_*_1951fbl   *     HTAN-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE H - 218
1fbl_*_1951fbl   *     ZNZINC ION H - 218
1fbl_*_1951fbl   *     HTAN-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE E - 219
1fbl_*_1951fbl   *     ZNZINC ION E - 219
1fbl_*_1951fbl   *     HTAN-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE H - 222
1fbl_*_1951fbl   *     ZNZINC ION H - 222
1hfc_*_1951hfc   *     HAP(N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL) PHENYLALANYL)METHYL AMINE Y - 210
1hfc_*_1951hfc   *     HAP(N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL) PHENYLALANYL)METHYL AMINE R - 214
1hfc_*_1951hfc   *     HAP(N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL) PHENYLALANYL)METHYL AMINE V - 215
1hfc_*_1951hfc   *     HAP(N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL) PHENYLALANYL)METHYL AMINE H - 218
1hfc_*_1951hfc   *     HAP(N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL) PHENYLALANYL)METHYL AMINE E - 219
1hfc_*_1951hfc   *     HAP(N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL) PHENYLALANYL)METHYL AMINE H - 222
1i76_A_1741i76   A     ZNZINC ION H - 175
1i76_A_1741i76   A     CACALCIUM ION D - 177
1i76_A_1741i76   A     CACALCIUM ION E - 179
1i76_A_1741i76   A     CACALCIUM ION E - 180
1i76_A_1741i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID L - 193
1i76_A_1741i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID V - 194
1i76_A_1741i76   A     ZNZINC ION H - 197
1i76_A_1741i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID H - 197
1i76_A_1741i76   A     ZNZINC ION E - 198
1i76_A_1741i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID E - 198
1i76_A_1741i76   A     ZNZINC ION H - 201
1i76_A_1741i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID H - 201

Clusters included in this Subclass
CLUSTER: EH.12.31