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Information on SUBCLASS 5.1.1
Subclass Accession number: 39
Subclass: 5.1.1
Type: EH beta-alpha
DB: ArchDB-KI
 Number of loops: 14

Average sequence ID (%) : 59.0 +/- 3.2
Average RMSD (Å) : 0.38 +/- 0.11

Consensus geometry
d (Å): 15 delta (°): 45-90 theta (°): 135-180 rho (°): 0-45
Consensus Sequence: hDGFPRphX
(φψ)-conformation: bbgbwabaa
Pattern: [IL][ILV]{D}[G][FY][P][R][EKNST]{ILMVY}x[NQ]{AG}{DEN}{AEKM}
Conservation:0.213-0.046-0.0331.4580.8921.9101.007-0.766-0.961-1.1110.168-0.647-1.107-0.976
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1ak2_*_971ak2   -98111LLDGFPRTVRQAEMEEES---SHHHHHHbxbvb-abaaaaaa
1ake_A_811ake   A8295LLDGFPRTIPQADAEEES---SHHHHHHbxbgb-abaaaaaa
1aky_*_861aky   -87100ILDGFPRTIPQAEKEEES---SHHHHHHbxbvb-abaaaaaa
1ank_A_821ank   A8295LLDGFPRTIPQADAEEES---SHHHHHHbxxgb-abaaaaaa
1dvr_A_861dvr   A87100ILVGFPRTIPQAEKEEES---SHHHHHHbxbvb-abaaaaaa
1qf9_A_861qf9   A87100LVDGFPRNEENNNSEEET---SHHHHHHxxbvb-abaaaaaa
1uke_*_861uke   -87100LVDGFPRNEENNNSEEET---SHHHHHHxxbvb-abaaaaaa
1uky_*_991uky   -101114LIDGFPRKMDQAISEEET---SHHHHHHbxxvb-abaaaaaa
1ukz_*_991ukz   -101114LIDGFPRKMDQAISEEET---SHHHHHHbbxvb-abaaaaaa
1zak_A_871zak   A88101LLDGYPRSYSQAMAEEES---SHHHHHHbxbvb-abaaaaaa
1zip_*_811zip   -8295LLDGFPRTVAQAEAEEES---SHHHHHHbxbvb-abaaaaaa
2ak3_A_852ak3   A8699LLDGFPRTLPQAEAEEES---SHHHHHHbxbvb-abaaaaaa
2eck_A_822eck   A8295LLDGFPRTIPQADAEEES---SHHHHHHbxbgb-abaaaaaa
3adk_*_903adk   -91104LIDGYPREVKQGEEEEES--SSHHHHHHbbxlb-abaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 84
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 85
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE F - 86
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE P - 87
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE R - 88
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE T - 89
1ake_A_811ake   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Q - 92
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 89
1aky_*_861aky   *     IMDIMIDAZOLE D - 89
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 90
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE F - 91
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE P - 92
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE R - 93
1aky_*_861aky   *     IMDIMIDAZOLE R - 93
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE T - 94
1aky_*_861aky   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Q - 97
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE D - 84
1ank_A_821ank   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER D - 84
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE G - 85
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE F - 86
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE P - 87
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE R - 88
1ank_A_821ank   A     ANPPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER R - 88
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE T - 89
1ank_A_821ank   A     AMPADENOSINE MONOPHOSPHATE Q - 92
1dvr_A_861dvr   A     ATFPHOSPHODIFLUOROMETHYLPHOSPHONIC ACID-ADENYLATE ESTER V - 89
1dvr_A_861dvr   A     ATFPHOSPHODIFLUOROMETHYLPHOSPHONIC ACID-ADENYLATE ESTER R - 93
1qf9_A_861qf9   A     ALFTETRAFLUOROALUMINATE ION D - 89
1qf9_A_861qf9   A     MGMAGNESIUM ION D - 89
1qf9_A_861qf9   A     ADPADENOSINE-5'-DIPHOSPHATE D - 89
1qf9_A_861qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE D - 89
1qf9_A_861qf9   A     ALFTETRAFLUOROALUMINATE ION G - 90
1qf9_A_861qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE G - 90
1qf9_A_861qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE F - 91
1qf9_A_861qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE P - 92
1qf9_A_861qf9   A     ALFTETRAFLUOROALUMINATE ION R - 93
1qf9_A_861qf9   A     ADPADENOSINE-5'-DIPHOSPHATE R - 93
1qf9_A_861qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE R - 93
1qf9_A_861qf9   A     C5PCYTIDINE-5'-MONOPHOSPHATE N - 97
1uke_*_861uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE D - 89
1uke_*_861uke   *     MGMAGNESIUM ION D - 89
1uke_*_861uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE G - 90
1uke_*_861uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE F - 91
1uke_*_861uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE P - 92
1uke_*_861uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE R - 93
1uke_*_861uke   *     UP5P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE N - 97
1uky_*_991uky   *     ADPADENOSINE-5'-DIPHOSPHATE D - 103
1uky_*_991uky   *     ADPADENOSINE-5'-DIPHOSPHATE G - 104
1uky_*_991uky   *     ADPADENOSINE-5'-DIPHOSPHATE F - 105
1uky_*_991uky   *     ADPADENOSINE-5'-DIPHOSPHATE P - 106
1uky_*_991uky   *     ADPADENOSINE-5'-DIPHOSPHATE R - 107
1uky_*_991uky   *     ADPADENOSINE-5'-DIPHOSPHATE Q - 111
1ukz_*_991ukz   *     ADPADENOSINE-5'-DIPHOSPHATE D - 103
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE D - 103
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE G - 104
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE F - 105
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE P - 106
1ukz_*_991ukz   *     ADPADENOSINE-5'-DIPHOSPHATE R - 107
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE R - 107
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE K - 108
1ukz_*_991ukz   *     AMPADENOSINE MONOPHOSPHATE Q - 111
1zak_A_871zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 90
1zak_A_871zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 91
1zak_A_871zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Y - 92
1zak_A_871zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE P - 93
1zak_A_871zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE R - 94
1zak_A_871zak   A     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Q - 98
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE D - 84
1zip_*_811zip   *     MNMANGANESE (II) ION D - 84
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE G - 85
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE F - 86
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE P - 87
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE R - 88
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE T - 89
1zip_*_811zip   *     AP5BIS(ADENOSINE)-5'-PENTAPHOSPHATE Q - 92
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE D - 88
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE G - 89
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE F - 90
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE P - 91
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE R - 92
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE T - 93
2ak3_A_852ak3   A     AMPADENOSINE MONOPHOSPHATE Q - 96
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE D - 84
2eck_A_822eck   A     ADPADENOSINE-5'-DIPHOSPHATE D - 84
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE G - 85
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE F - 86
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE P - 87
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE R - 88
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE T - 89
2eck_A_822eck   A     AMPADENOSINE MONOPHOSPHATE Q - 92
Bibliographic annotations
LoopPDBChainAnnotationResidue
1ake_A_811ake   RefC.W.MUELLER,G.E.SCHULZ. STRUCTURE OF THE COMPLEX BETWEEN ADENYLATE KINASE FROM ESCHERICHIA COLI AND THE INHIBITOR AP=5=A REFINED AT 1.9 ANGSTROMS RESOLUTION: A MODEL FOR A CATALYTIC TRANSITION STATE  J.MOL.BIOL. v.224;159,1992AAMP BINDING RESIDUE R - 88
1ake_A_811ake   RefC.W.MUELLER,G.E.SCHULZ. STRUCTURE OF THE COMPLEX BETWEEN ADENYLATE KINASE FROM ESCHERICHIA COLI AND THE INHIBITOR AP=5=A REFINED AT 1.9 ANGSTROMS RESOLUTION: A MODEL FOR A CATALYTIC TRANSITION STATE  J.MOL.BIOL. v.224;159,1992AAMP BINDING RESIDUE Q - 92
1ank_A_821ank   RefM.B.BERRY,B.MEADOR,T.BILDERBACK,P.LIANG,M.GLASER,G.N.PHILLIPS JUNIOR. THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP  PROTEINS v.19;183,1994AMg ION BINDING RESIDUED - 84
1ank_A_821ank   RefM.B.BERRY,B.MEADOR,T.BILDERBACK,P.LIANG,M.GLASER,G.N.PHILLIPS JUNIOR. THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP  PROTEINS v.19;183,1994AAMP BINDING RESIDUE G - 85
1ank_A_821ank   RefM.B.BERRY,B.MEADOR,T.BILDERBACK,P.LIANG,M.GLASER,G.N.PHILLIPS JUNIOR. THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP  PROTEINS v.19;183,1994AAMP BINDING RESIDUE R - 88
1ank_A_821ank   RefM.B.BERRY,B.MEADOR,T.BILDERBACK,P.LIANG,M.GLASER,G.N.PHILLIPS JUNIOR. THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP  PROTEINS v.19;183,1994AAMP BINDING RESIDUE Q - 92
1zak_A_871zak   RefK.WILD,R.GRAFMULLER,E.WAGNER,G.E.SCHULZ. STRUCTURE, CATALYSIS AND SUPRAMOLECULAR ASSEMBLY OF ADENYLATE KINASE FROM MAIZE  EUR.J.BIOCHEM. v.250;326,1997AMg ION BINDING RESIDUED - 90
1zak_A_871zak   RefK.WILD,R.GRAFMULLER,E.WAGNER,G.E.SCHULZ. STRUCTURE, CATALYSIS AND SUPRAMOLECULAR ASSEMBLY OF ADENYLATE KINASE FROM MAIZE  EUR.J.BIOCHEM. v.250;326,1997AAMP BINDING RESIDUE R - 94
2eck_A_822eck   RefM.B.BERRY,T.BILDERBACK,M.GLASER,G.N.PHILLIPS JUNIOR. A CRYSTAL STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND ADP  PROTEINS v.15;276,1998AMg ION BINDING RESIDUED - 84
2eck_A_822eck   RefM.B.BERRY,T.BILDERBACK,M.GLASER,G.N.PHILLIPS JUNIOR. A CRYSTAL STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND ADP  PROTEINS v.15;276,1998AAMP BINDING RESIDUE G - 85
2eck_A_822eck   RefM.B.BERRY,T.BILDERBACK,M.GLASER,G.N.PHILLIPS JUNIOR. A CRYSTAL STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND ADP  PROTEINS v.15;276,1998AAMP BINDING RESIDUE R - 88
2eck_A_822eck   RefM.B.BERRY,T.BILDERBACK,M.GLASER,G.N.PHILLIPS JUNIOR. A CRYSTAL STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND ADP  PROTEINS v.15;276,1998AAMP BINDING RESIDUE Q - 92

Clusters included in this Subclass
CLUSTER: EH.4.12