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Information on SUBCLASS 12.4.1
Subclass Accession number: 4285
Subclass: 12.4.1 PSSM
Type: AR beta-beta link
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4.21 (>75 %)  5.2 (>75 %)  5.2.1 (>75 %)  5.2.1.8 (>75 %)  
GO : GO:0003755 (>75 %)  GO:0004252 (>50 %)  GO:0008236 (>50 %)  GO:0016853 (>75 %)  GO:0016859 (>75 %)  
SCOP : 50493 (>75 %)  50494 (>75 %)  50514 (>75 %)  50890 (>75 %)  50891 (>75 %)  50892 (>75 %)  
 Number of loops: 8

Average sequence ID (%) : 67.9 +/- 20.4
Average RMSD (Å) : 0.188 +/- 0.083

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 45-90 rho (°): 180-225
Consensus Sequence: ITXXXXXWLDGpHVVF
(φψ)-conformation: bpabpbaaaplabppN
Pattern: [F][F][IL][CT][CLT][ASTV][KP][ACPT][ADEPT][HW][L][DN][GN][kr][H][V][V][F][G][KR][IV][IKLV][DES]
Conservation:1.2621.262-0.172-0.363-1.104-1.201-0.524-1.293-1.4280.6820.2620.143-0.080-1.1682.2620.2620.2621.2621.2620.1110.023-1.140-0.579
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a33_*_1231a33   -123145FFITTTPAPHLNNIHVVFGKVVSEEEESS--GGGTTTS-EEEEEEEbbbxabwbaaaxvabxxabbxab
1cyn_A_1201cyn   A120142FFITTVKTAWLDGKHVVFGKVLEEEEESS--GGGTTTS-EEEEEEEbbbxabxbaaaxvabxxabbxab
1dyw_A_1191dyw   A119141FFLCTVKTEWLDGKHVVFGRVVEEEEESS--GGGTTTS-EEEEEEEbbbxabxaaaapvabxxNebxab
1h0p_A_1361h0p   A136158FFITTVKTPWLDGRHVVFGKILEEEEESS--GGGTTTS-EEEEEEEbbbxabxbaaaxvabxxNbbxab
1qng_A_1191qng   A119141FFITLVPCPWLDGKHVVFGKVIEEEEESS--GGGTTTS-EEEEEEEbbbxabwbaaapvabxxabbxab
1qoi_A_1241qoi   A124146FFITCSKCDWLDGKHVVFGKIIDEEEESS--GGGTTTS-EEEEEEEbbbxabxbaaaxvabxxabbxab
2cpl_*_1122cpl   -112134FFICTAKTEWLDGKHVVFGKVKEEEEESS--GGGTTTS-EEEEEEEbbbxabxbaaapvabxxNbbxab
2rmc_A_1462rmc   A146168FFITLTKPTWLDGKHVVFGKVLDEEEESS--GGGTTTS-EEEEEEEbbbxabbxaaapvabxxNbbxab
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1cyn_A_1201cyn   A     MVAN-METHYLVALINE F - 120
1cyn_A_1201cyn   A     MVAN-METHYLVALINE F - 121
1cyn_A_1201cyn   A     MLEN-METHYLLEUCINE W - 129
1cyn_A_1201cyn   A     MLEN-METHYLLEUCINE L - 130
1cyn_A_1201cyn   A     MVAN-METHYLVALINE L - 130
1cyn_A_1201cyn   A     BMT4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE H - 134
1cyn_A_1201cyn   A     MLEN-METHYLLEUCINE H - 134
1cyn_A_1201cyn   A     MVAN-METHYLVALINE H - 134
1h0p_A_1361h0p   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE F - 137
1h0p_A_1361h0p   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE W - 145
1h0p_A_1361h0p   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE L - 146
1h0p_A_1361h0p   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE R - 149
1h0p_A_1361h0p   A     DTT2,3-DIHYDROXY-1,4-DITHIOBUTANE H - 150
1qng_A_1191qng   A     MVAN-METHYLVALINE F - 119
1qng_A_1191qng   A     MLEN-METHYLLEUCINE W - 128
1qng_A_1191qng   A     MLEN-METHYLLEUCINE L - 129
1qng_A_1191qng   A     MVAN-METHYLVALINE L - 129
1qng_A_1191qng   A     BMT4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE H - 133
1qng_A_1191qng   A     MLEN-METHYLLEUCINE H - 133
1qng_A_1191qng   A     MVAN-METHYLVALINE H - 133
2rmc_A_1462rmc   A     MVAN-METHYLVALINE F - 146
2rmc_A_1462rmc   A     MVAN-METHYLVALINE F - 147
2rmc_A_1462rmc   A     MLEN-METHYLLEUCINE W - 155
2rmc_A_1462rmc   A     MVAN-METHYLVALINE W - 155
2rmc_A_1462rmc   A     MLEN-METHYLLEUCINE L - 156
2rmc_A_1462rmc   A     MVAN-METHYLVALINE L - 156
2rmc_A_1462rmc   A     BMT4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE H - 160
2rmc_A_1462rmc   A     MLEN-METHYLLEUCINE H - 160
2rmc_A_1462rmc   A     MVAN-METHYLVALINE H - 160
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1dyw_A_1191dyw   A CBSCYCLOSPORIN BINDING SITEF - 120
1dyw_A_1191dyw   A CBSCYCLOSPORIN BINDING SITEW - 128
1dyw_A_1191dyw   A CBSCYCLOSPORIN BINDING SITEH - 133

Clusters included in this Subclass
CLUSTER: AR.11.3