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Information on SUBCLASS 16.4.1
Subclass Accession number: 4320
Subclass: 16.4.1 PSSM
Type: AR beta-beta link
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 21 (>50 %)  3 (>50 %)  3.4 (>75 %)  3.4.24 (>75 %)  4 (>50 %)  
GO : GO:0004175 (>75 %)  GO:0004222 (>75 %)  GO:0004252 (>50 %)  GO:0005509 (>75 %)  GO:0008233 (>75 %)  GO:0008236 (>50 %)  GO:0008237 (>75 %)  GO:0008270 (>75 %)  
SCOP : 50493 (>75 %)  50494 (>75 %)  50514 (>75 %)  55485 (>75 %)  55486 (>75 %)  55528 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 65.4 +/- -15.8
Average RMSD (Å) : 0.167 +/- 0.058

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 90-135 rho (°): 315-360
Consensus Sequence: hpXXHXDppPFDGPccXLAH
(φψ)-conformation: bbepalalbppaepeepabb
Pattern: [I]x[I][AGS][F][AVY][QR][GR][AD][H][GR][D][NS][SY][P][F][D][G][P][GN][GN]x[L][A][H][A]
Conservation:-0.014-1.030-0.014-1.0190.890-1.370-0.449-0.968-1.0521.794-0.9360.890-0.387-1.0921.3420.8900.8900.8901.342-0.440-0.440-1.471-0.014-0.0141.794-0.014
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1cgl_A_1591cgl   A159184IMISFVRGDHRDNSPFDGPGGNLAHAEEEEEE-S--SSS----SSSS--EEEbbbbbbbexalavbxxaexeexabbb
1i76_A_1381i76   A138163INIAFYQRDHGDNSPFDGPNGILAHAEEEEEE-S--SSS----SSSS--EEEbxbbbbbexavavbxxaeweexabbb
1mmq_*_1591mmq   -159184IMIGFARGAHGDSYPFDGPGNTLAHAEEEEEE-S--SSS----SSSS--EEExxbbbbbexagavbxxaepeexabbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1cgl_A_1591cgl   A     ZNZINC ION V - 164
1cgl_A_1591cgl   A     ZNZINC ION H - 168
1cgl_A_1591cgl   A     ZNZINC ION D - 170
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP D - 170
1cgl_A_1591cgl   A     ZNZINC ION S - 172
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP S - 172
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP P - 173
1cgl_A_1591cgl   A     ZNZINC ION F - 174
1cgl_A_1591cgl   A     CACALCIUM ION F - 174
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP F - 174
1cgl_A_1591cgl   A     CACALCIUM ION D - 175
1cgl_A_1591cgl   A     EMRN-AMINOETHYLMORPHOLINE D - 175
1cgl_A_1591cgl   A     CACALCIUM ION G - 176
1cgl_A_1591cgl   A     CACALCIUM ION P - 177
1cgl_A_1591cgl   A     CACALCIUM ION G - 178
1cgl_A_1591cgl   A     EMRN-AMINOETHYLMORPHOLINE G - 178
1cgl_A_1591cgl   A     CACALCIUM ION G - 179
1cgl_A_1591cgl   A     EMRN-AMINOETHYLMORPHOLINE G - 179
1cgl_A_1591cgl   A     CACALCIUM ION N - 180
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP N - 180
1cgl_A_1591cgl   A     EMRN-AMINOETHYLMORPHOLINE N - 180
1cgl_A_1591cgl   A     CACALCIUM ION L - 181
1cgl_A_1591cgl   A     EMRN-AMINOETHYLMORPHOLINE L - 181
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP A - 182
1cgl_A_1591cgl   A     ZNZINC ION H - 183
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP H - 183
1cgl_A_1591cgl   A     CBZCARBOBENZOXY GROUP A - 184
1i76_A_1381i76   A     CACALCIUM ION I - 138
1i76_A_1381i76   A     CACALCIUM ION N - 139
1i76_A_1381i76   A     ZNZINC ION Y - 143
1i76_A_1381i76   A     ZNZINC ION H - 147
1i76_A_1381i76   A     ZNZINC ION D - 149
1i76_A_1381i76   A     ZNZINC ION S - 151
1i76_A_1381i76   A     CACALCIUM ION F - 153
1i76_A_1381i76   A     ZNZINC ION F - 153
1i76_A_1381i76   A     CACALCIUM ION D - 154
1i76_A_1381i76   A     CACALCIUM ION G - 155
1i76_A_1381i76   A     CACALCIUM ION P - 156
1i76_A_1381i76   A     CACALCIUM ION N - 157
1i76_A_1381i76   A     CACALCIUM ION G - 158
1i76_A_1381i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID G - 158
1i76_A_1381i76   A     CACALCIUM ION I - 159
1i76_A_1381i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID I - 159
1i76_A_1381i76   A     CACALCIUM ION L - 160
1i76_A_1381i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID L - 160
1i76_A_1381i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID A - 161
1i76_A_1381i76   A     ZNZINC ION H - 162
1i76_A_1381i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID H - 162
1i76_A_1381i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID A - 163
1mmq_*_1591mmq   *     CACALCIUM ION M - 160
1mmq_*_1591mmq   *     ZNZINC ION Y - 172
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE D - 175
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE G - 178
1mmq_*_1591mmq   *     CACALCIUM ION N - 179
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE N - 179
1mmq_*_1591mmq   *     CACALCIUM ION T - 180
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE T - 180
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE L - 181
1mmq_*_1591mmq   *     ZNZINC ION A - 182
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE A - 182
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE H - 183
1mmq_*_1591mmq   *     RRSN4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE A - 184

Clusters included in this Subclass
CLUSTER: AR.16.4