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Information on SUBCLASS 12.8.1
Subclass Accession number: 5143
Subclass: 12.8.1 PSSM
Type: HH alpha-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 5.4 (>50 %)  5.4.2 (>50 %)  5.4.2.1
GO : GO:0004619 (>50 %)  GO:0016853 (>50 %)  GO:0016866 (>50 %)  GO:0016868 (>50 %)  
SCOP : 53253 (>75 %)  53254 (>75 %)  53255 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 48.9 +/- 7.0
Average RMSD (Å) : 0.467 +/- 0.115

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 90-135 rho (°): 0-45
Consensus Sequence: XppXhpGWXDXXLpXK
(φψ)-conformation: aalbpaeappppppaa
Pattern: [EKQ][W][N]x[EK][NR]x[FM][QT][G][W]x[D][SV][DKP][L][ST][AE][K][G]x[QS][DE][A][AKM][AR][AL][G][EK]x
Conservation:-0.3492.8030.937-0.971-0.148-0.214-0.738-0.214-0.5230.9372.803-0.9710.937-0.896-0.8050.190-0.289-0.5610.5630.937-1.054-0.3710.0840.190-0.971-0.547-0.7150.937-0.148-0.832
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1e58_A_141e58   A1443QWNKENRFTGWYDVDLSEKGVSEAKAAGKLHHHHTTB--TT----B-HHHHHHHHHHHHHaaaaavbxaeapxxxpxaaaaaaaaaaaaa
1h2e_A_141h2e   A1443KWNVERRMQGWQDSPLTEKGRQDAMRLGKRHHHHTTB--TTS---B-HHHHHHHHHHHHHaaaaalbxaeaxbbxxxaaaaaaaaaaaaa
1qhf_A_121qhf   A1241EWNEKNLFTGWVDVKLSAKGQQEAARAGELHHHHTTB--TTS---B-HHHHHHHHHHHHHaaaaavbxaeaxxxxxxaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1e58_A_141e58   A     PHSPHOSPHONO GROUP N - 16
1e58_A_141e58   A     PHSPHOSPHONO GROUP T - 22
1e58_A_141e58   A     PHSPHOSPHONO GROUP G - 23
1h2e_A_141h2e   A     PO4PHOSPHATE ION N - 16
1h2e_A_141h2e   A     EDO1,2-ETHANEDIOL R - 20
1h2e_A_141h2e   A     EDO1,2-ETHANEDIOL M - 21
1h2e_A_141h2e   A     PO4PHOSPHATE ION Q - 22
1h2e_A_141h2e   A     EDO1,2-ETHANEDIOL Q - 22
1h2e_A_141h2e   A     PO4PHOSPHATE ION G - 23
1h2e_A_141h2e   A     EDO1,2-ETHANEDIOL G - 23
1h2e_A_141h2e   A     EDO1,2-ETHANEDIOL W - 24
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID W - 13
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID N - 14
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID E - 15
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID L - 18
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID F - 19
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID T - 20
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID G - 21
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID V - 25
1qhf_A_121qhf   A     3PG3-PHOSPHOGLYCERIC ACID E - 34
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1h2e_A_141h2e   A PO4PO4 BINDING SITE FOR CHAIN AN - 16
1h2e_A_141h2e   A PO4PO4 BINDING SITE FOR CHAIN AQ - 22
1h2e_A_141h2e   A EA2EDO BINDING SITE FOR CHAIN AG - 23

Clusters included in this Subclass
CLUSTER: HH.12.32