ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 14.4.1

Subclass Accession number: 5156
Subclass: 14.4.1

Type: HH alpha-alpha
DB: ArchDB95

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 2.6 (>75 %)  2.6.1 (>75 %)  2.6.1.1
GO : GO:0003700 (>75 %)  GO:0004069 (>75 %)  GO:0008483 (>75 %)  GO:0016769 (>75 %)
SCOP : 51331 (>75 %)  51332 (>75 %)  51333 (>75 %)  53382 (>75 %)  53383 (>75 %)  53384 (>75 %)

Number of loops: 3

Average sequence ID (%) : 51.4 +/- 3.7
Average RMSD (Å) : 0.500 +/- 0.100

Consensus geometry

d (Å): 19

delta (°): 135-180

theta (°): 45-90

rho (°): 0-45

Consensus Sequence:	hppXYXXEXWTLQDXXXE
(φψ)-conformation:	aabaaaappbpaaaapaa

Pattern:	[K]	[AG]	[HL]	[KNQ]	[A]	[I]	[E]	[LM]	[Q]	[LM]	x	[L]	[EQ]	[GST]	[IL]	[AY]	[KNQ]	[ST]	[AQ]	[Y]	[GKS]	[NTV]	[E]	[DKP]	[W]	[T]	[L]	[Q]	[D]	[TV]	[CS]	x	[E]	[LMV]	[WY]
Conservation:	0.710	-0.519	-0.703	-0.709	0.237	0.237	0.710	-0.141	0.710	-0.055	-1.181	0.237	0.032	-0.971	-0.220	-0.897	-0.709	-0.367	-0.719	1.655	-1.076	-1.181	0.710	-1.024	3.546	0.710	0.237	0.710	1.182	-0.512	-0.524	-1.444	0.710	-0.551	1.173

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1dto_A_62	1dto	A	68	102	KALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVY	HHHHHHHHHHHHHHHHTSTTTTS---TTTTSHHHH	aaaaaaaaaaaaaaaaabaaaaxxbxaaaaxaaaa
1qqh_A_68	1qqh	A	68	102	KAHKAIELQMALQGLAQSAYKTEDWTLQDTCEELW	HHHHHHHHHHHHHHHHHSTTTTS---TTTTSHHHH	aaaaaaaaaaaaaaaaaxaaaaxxbxaaaaxaaaa
1r6n_A_62	1r6n	A	68	102	KGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYEMW	HHHHHHHHHHHHHHHHTSTTTTS---TTTTSHHHH	aaaaaaaaaaaaaaaaabaaaaxwbxaaaaxaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	T - 63
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	V - 64
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	S - 65
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	T - 67
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	K - 68
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	N - 71
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	L - 79
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	T - 93
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	L - 94
1r6n_A_62	1r6n	A	ALQ2-METHYL-PROPIONIC ACID	L - 94
1r6n_A_62	1r6n	A	DMSDIMETHYL SULFOXIDE	L - 94
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	Q - 95
1r6n_A_62	1r6n	A	DMSDIMETHYL SULFOXIDE	Q - 95
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	T - 97
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	S - 98
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	Y - 99
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	E - 100
1r6n_A_62	1r6n	A	434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]	M - 101

Clusters included in this Subclass

CLUSTER: HH.14.22