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Information on SUBCLASS 2.12.1
Subclass Accession number: 5448
Subclass: 2.12.1 PSSM
Type: HE alpha-beta
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.2 (>75 %)  3.2.2 (>75 %)  3.2.2.22 (>75 %)  
GO : GO:0016798 (>75 %)  GO:0016799 (>75 %)  GO:0030597 (>75 %)  
SCOP : 56370 (>75 %)  56371 (>75 %)  56372 (>75 %)  
 Number of loops: 5

Average sequence ID (%) : 14.4 +/- 16.7
Average RMSD (Å) : 0.480 +/- 0.110

Consensus geometry
d (Å): 7 delta (°): 0-45 theta (°): 90-135 rho (°): 0-45
Consensus Sequence: phpGpp
(φψ)-conformation: aaplbb
Pattern: [aelm][DEK][deky][FITV][EKRS][GY]x[EKSW][gil]
Conservation:-0.6901.262-1.174-0.0450.5191.6980.010-0.513-1.065
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1hd2_A_251hd2   A2634AELFKGKKGHHHTTTSEEaaaaxvbbb
1hs6_A_4001hs6   A411419VEKFSYKSIHHHHTTEEEaaaapvbbb
1j54_A_791j54   A8795MDYIRGAELHHHHTTSEEaaaapvxxx
1n8j_A_251n8j   A2533EKDTEGRWSHHHHTTSEEaaaaxvbxb
2aps_A_1302aps   A130138LDEVKGHSLHHHHTTEEEaaaaxvbbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1j54_A_791j54   A     EGLETHYLENE GLYCOL G - 92
1j54_A_791j54   A     EGLETHYLENE GLYCOL A - 93
1j54_A_791j54   A     MNMANGANESE (II) ION I - 97
2aps_A_1302aps   A     CUCOPPER (II) ION M - 139
2aps_A_1302aps   A     CUCOPPER (II) ION I - 140
2aps_A_1302aps   A     CUCOPPER (II) ION H - 141
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
2aps_A_1302aps   A ACTCOPPER AND ZINC ARE LIGATED BY THREE CONSERVED HISTIDINES EACH IN THE ACTIVE SITE OF EACH SUBUNIT.H - 141

Clusters included in this Subclass
CLUSTER: HE.2.111
CLUSTER: HE.3.270