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Information on SUBCLASS 14.1.1
Subclass Accession number: 56
Subclass: 14.1.1
Type: EH beta-alpha
DB: ArchDB-KI
 Number of loops: 6

Average sequence ID (%) : 89.3 +/- 1.0
Average RMSD (Å) : 0.33 +/- 0.04

Consensus geometry
d (Å): 15 delta (°): 45-90 theta (°): 135-180 rho (°): 270-315
Consensus Sequence: CATQMLESMXppPRPTRA
(φψ)-conformation: bbMlaaaaaaababppaa
Pattern: [V][I][C][A][T][Q][M][L][E][S][M][IT][KY][KN][P][R][P][T][R][A][E][GV][S][D][V][AG][N][A][IV][L]
Conservation:-0.278-0.2782.810-0.2780.3400.3400.340-0.2780.340-0.2780.340-1.667-1.513-1.0501.5750.3401.5750.3400.340-0.2780.340-2.130-0.2780.957-0.278-1.2040.957-0.278-0.587-0.278
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a3w_A_2941a3w   A294323VICATQMLESMTYNPRPTRAEVSDVGNAILEEE-SSTTGGGGS-SS--HHHHHHHHHHHHbbbbMlaaaaaaababxxaaaaaaaaaaaa
1a3x_A_2941a3x   A294323VICATQMLESMTYNPRPTRAEVSDVGNAILEEEESSSSGGGGT-SS--HHHHHHHHHHHHbbxbMlaaaaaaababxxaaaaaNaaaaaa
1a49_A_3231a49   A323352VICATQMLESMIKKPRPTRAEGSDVANAVLEEEESSTTGGGGT-SS--HHHHHHHHHHHHbbxbMvaaaaaaababxxaaaaaaaaaaaa
1aqf_A_3231aqf   A323352VICATQMLESMIKKPRPTRAEGSDVANAVLEEEESSSSGGGGT-SS--HHHHHHHHHHHHbbbbeUaaaaaaababxxaaaaaaaaaaaa
1pkm_*_3231pkm   -323352VICATQMLESMIKKPRPTRAEGSDVANAVLEEEESSSSGGGGT-SS--HHHHHHHHHHHHbbxbMvaaaaaaabab-xaaaaaaaaaaaa
1pkn_*_3231pkn   -323352VICATQMLESMIKKPRPTRAEGSDVANAVLEEEESSSS-GGGTSSS--HHHHHHHHHHHHbbbbMvaaaaaaabax-xaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1a3w_A_2941a3w   A     PGA2-PHOSPHOGLYCOLIC ACID A - 297
1a3w_A_2941a3w   A     PGA2-PHOSPHOGLYCOLIC ACID T - 298
1a3x_A_2941a3x   A     PGA2-PHOSPHOGLYCOLIC ACID A - 297
1a3x_A_2941a3x   A     PGA2-PHOSPHOGLYCOLIC ACID T - 298
1a49_A_3231a49   A     OXLOXALATE ION A - 326
1a49_A_3231a49   A     OXLOXALATE ION T - 327
1a49_A_3231a49   A     MGMAGNESIUM ION T - 327
1a49_A_3231a49   A     ATPADENOSINE-5'-TRIPHOSPHATE T - 327
1aqf_A_3231aqf   A     PEQL-PHOSPHOLACTATE A - 326
1aqf_A_3231aqf   A     PEQL-PHOSPHOLACTATE T - 327
1pkn_*_3231pkn   *     PYRPYRUVIC ACID A - 326
1pkn_*_3231pkn   *     PYRPYRUVIC ACID T - 327
Bibliographic annotations
LoopPDBChainAnnotationResidue
1a3w_A_2941a3w   RefM.S.JURICA,A.MESECAR,P.J.HEATH,W.SHI,T.NOWAK,B.L.STODDARD. THE ALLOSTERIC REGULATION OF PYRUVATE KINASE BY FRUCTOSE-1,6-BISPHOSPHATE  STRUCTURE (LONDON) v.6;195,1998ACATALYTIC RESIDUET - 298
1aqf_A_3231aqf   RefT.M.LARSEN,M.M.BENNING,G.E.WESENBERG,I.RAYMENT,G.H.REED. LIGAND-INDUCED DOMAIN MOVEMENT IN PYRUVATE KINASE: STRUCTURE OF THE ENZYME FROM RABBIT MUSCLE WITH MG2+, K+, AND L-PHOSPHOLACTATE AT 2.7 A RESOLUTION  ARCH.BIOCHEM.BIOPHYS. v.345;199,1997ALACTATE BINDING RESIDUET - 327

Clusters included in this Subclass
CLUSTER: EH.14.0