ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 2.2.1

Subclass Accession number: 62
Subclass: 2.2.1
Type: HA beta-beta hairpin
DB: ArchDB-KI

Number of loops: 7

Average sequence ID (%) : 24.4 +/- 9.4
Average RMSD (Å) : 0.40 +/- 0.16

Consensus geometry

d (Å): 5

delta (°): 45-90

theta (°): 135-180

rho (°): 270-315

Consensus Sequence:	pXpXXX
(φψ)-conformation:	bbaabb

Pattern:	[AILV]	[EHKR]	{DKTY}	x	[FG]	[EKRT]	[DG]	[EKNS]	x	x	x	[VY]	{FLM}	x	[CGLMV]
Conservation:	0.400	0.617	-1.461	-0.719	0.372	0.212	1.537	0.419	1.241	-0.007	-1.222	1.268	-0.035	-1.360	-1.262

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1a6o_*_39	1a6o	-	42	56	VRKVGRGKYSEVFEG	EEEEEE-SSEEEEEE	abxabbbaabbbbxb
1apm_E_106	1apm	E	106	120	LEFSFKDNSNLYMVM	EEEEEE-SSEEEEEE	xabbbbbaabbbbbb
1apm_E_43	1apm	E	46	60	IKTLGTGSFGRVMLV	EEEEEE-SSEEEEEE	abxabbbaabbbbxb
1cdk_A_106	1cdk	A	106	120	LEYSFKDNSNLYMVM	EEEEEE-SSEEEEEE	xabbbbbaabbbbbb
1kob_A_113	1kob	A	113	127	LHDAFEDKYEMVLIL	EEEEEE-SSEEEEEE	xabbbbbaabbbbxb
1tki_A_24	1tki	A	27	41	AEDLGRGEFGIVHRC	EEEEEE-SSEEEEEE	bpxabbbaabbbbxb
1ydr_E_106	1ydr	E	106	120	LEFSFKDNSNLYMVM	EEEEEE-SSEEEEEE	xabbbbbaabbbbbb

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1apm_E_106	1apm	E	PHOPHEOPHYTIN A	S - 114
1ydr_E_106	1ydr	E	SEPPHOSPHOSERINE	N - 113
1ydr_E_106	1ydr	E	SEPPHOSPHOSERINE	S - 114
1ydr_E_106	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	M - 120
1ydr_E_106	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	E - 121

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	L - 49
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	GLY-RICH-LOOP	G - 50
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	GLY-RICH-LOOP	G - 52
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	P-ATP BINDING RESIDUE	S - 53
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	P-ATP BINDING RESIDUE	F - 54
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	GLY-RICH-LOOP	G - 55
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	P-ATP BINDING RESIDUE	G - 55
1apm_E_43	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	V - 57
1apm_E_106	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	M - 120
1apm_E_106	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	E - 121

Clusters included in this Subclass

CLUSTER: HA.2.10