ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 11.2.3

Subclass Accession number: 6583
Subclass: 11.2.3

Type: HA beta-beta hairpin
DB: ArchDB95

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 2.6 (>50 %)  2.6.1 (>50 %)
GO : GO:0008483 (>50 %)  GO:0016769 (>50 %)
SCOP : 53382 (>75 %)  53383 (>75 %)  53384 (>50 %)

Number of loops: 3

Average sequence ID (%) : 39.1 +/- 14.8
Average RMSD (Å) : 0.367 +/- 0.115

Consensus geometry

d (Å): 7

delta (°): 45-90

theta (°): 135-180

rho (°): 315-360

Consensus Sequence:	XShSKchGhhXXRXG
(φψ)-conformation:	bbaaaaalaaaalbb

Pattern:	[LV]	[FHL]	[CIV]	[AV]	x	[S]	[CFL]	[S]	[K]	[DN]	[FL]	[G]	[IL]	[PY]	[GNR]	[EF]	[R]	[TV]	[G]	[ACN]	[IL]	[LTY]	[ASV]
Conservation:	-0.081	-1.006	-0.388	-0.407	-1.144	0.781	-0.800	0.781	1.399	0.533	0.037	2.018	0.202	-0.334	-0.800	-0.878	1.399	-0.291	2.018	-1.075	0.187	-1.144	-1.006

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1ajs_A_250	1ajs	A	250	272	LFCAQSFSKNFGLYNERVGNLTV	EEEEEE-TTTS--GGG-EEEEEE	bbbxbbaaaaavaaaalbbbbxb
1m7y_A_265	1m7y	A	265	287	VHVVYSLSKDLGLPGFRVGAIYS	EEEEEESSSSS--GGG-EEEEEE	bbbbbbaaaaavaaaalbbbbbb
2ay1_A_250	2ay1	A	250	272	VLIAASCSKNFGIYRERTGCLLA	EEEEEE-TTTTT-GGG-EEEEEE	bbbbxbaaaaavaaaavbbbbbb

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	Q - 254
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	S - 255
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	F - 256
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	S - 257
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	K - 258
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	Y - 263
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	R - 266
1ajs_A_250	1ajs	A	PLA2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID	V - 267
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	V - 268
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	Y - 269
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	S - 270
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	L - 271
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	S - 272
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	K - 273
1m7y_A_265	1m7y	A	MPD2-METHYL-2,4-PENTANEDIOL	K - 273
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	P - 278
1m7y_A_265	1m7y	A	MPD2-METHYL-2,4-PENTANEDIOL	P - 278
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	R - 281
1m7y_A_265	1m7y	A	MPD2-METHYL-2,4-PENTANEDIOL	R - 281
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	V - 282
1m7y_A_265	1m7y	A	PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID	G - 283
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	A - 254
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	S - 255
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	C - 256
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	S - 257
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	K - 258
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	Y - 263
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	R - 266
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	T - 267
2ay1_A_250	2ay1	A	PLPPYRIDOXAL-5'-PHOSPHATE	G - 268

Clusters included in this Subclass

CLUSTER: HA.10.34